305 abstracts found.



Evaluation of novel isoquinolones as cytotoxic agents in hepatocellular carcinoma

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Mai Ali1,Asma Belgath1,Sally Freeman1,Katherine Finegan1,Ian Stratford1
1University of Manchester

Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK

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Robert Watson1,Hugo De La Peña1,Maria Tsakok1,William Halliwell1,Johnson Joseph1,Sara Stoneham2,Jonathan Shamash3,Johnathan Joffe4,Danish Mazhar5,Ling Pei Ho1,Zoe Traill6,Sue Brand7,Andrew Protheroe1
1University of Oxford,2University College London Hospitials NHS Foundation Trust,3Barts Health NHS Trust,4Calderdale & Huddersfield NHS Foundation Trust,5Cambridge University Hospitals NHS Foundation Trust,6Oxford University NHS Foundation Trust,7University Hospitals Bristol

How well are we as Physicians Managing EGFR Inhibitor-induced Cutaneous Toxicity?

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Lorna Dodd1,Jenny Smith2
1Newcastle Cancer centre,2Newcastle Cancer Centre

HER-targeted tyrosine kinase inhibitors are a promising treatment for platinum-resistant epithelial ovarian cancer

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Maria Bonello1,Simon Langdon1,Andrew Sims1
1University of Edinburgh

The NIHR Chemotherapy and Pharmacy Advisory Service (CPAS) : first 10 year review

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Joanna Askey1,Pippa Corrie1,Jonathan Gower1
1NIHR

Variation in surgical practices of oesophagectomy for oesophageal cancers: A unit survey of the Oesophagogastric Anastomosis Audit (OGAA)

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Benjamin Jefferies1,Sivesh Kamaraja1,Kwabena Siaw ‐ Acheampong1,James Bundred1,Dmitri Nepogodiev1,Pritam Singh2,Richard Evans2,Imran Mohamed3,Siobhan McKay4,Kasun Wanigsooriya4,Tony Whitehouse5,Derek Alderson6,James Gossage7,Richard van Hillegersberg8,Ravinder Vohra9,Ewen Griffiths5
1University of Birmingham,2General Surgery Trainee - West Midlands Deanery,3General Surgery Trainee – West Midlands Deanery,4General Surgery Trainee – West Midlands Deanery,5University Hospitals Birmingham NHS Foundation Trust,6Royal College of Surgeons England,7Guy’s and St. Thomas’ NHS Foundation Trust,8UMC Utrecht,9Nottingham University Hospitals NHS Trust

SCALOP-2: A randomised trial of induction GEMABX followed by chemoradiation (high/standard dose radiation) +/-nelfinavir for locally advanced pancreatic cancer: results of the dose-finding component

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Somnath Mukherjee1,Pradeep S. Virdee2,Rachel Shaw3,John Bridgewater4,Ganesh Radhakrishna5,Stephen Falk6,Martin Scott-Brown7,Victoria Y. Strauss2,Claire Brookes3,Roopinder Gillmore8,Neel Patel9,Bethan Tranter10,Phil Parsons11,David Sebag-Montefiore12,Maria Hawkins1,Pippa Corrie13,Tim Maughan1
1Department of Oncology, University of Oxford, Oxford, UK,2Centre for Statistics in Medicine, University of Oxford, Oxford, UK,3Oncology Clinical Trials Office, University of Oxford, Oxford, UK,4Department of Oncology, University College London Hospitals, London, UK,5Oncology Department, The Christie NHS Foundation Trust, Manchester, UK,6Bristol Haematology and Cancer Centre, Bristol University Hospitals NHS Foundation Trust, Bristol, UK,7Arden Cancer Centre, University Hospitals Coventry & Warwickshire, Coventry, UK,8Academic Oncology, Royal Free Hospital NHS Foundation Trust, London, UK,9Department of Radiology, Churchill Hospital, Oxford, UK,10Pharmacy Department, Velindre Cancer Centre, Velindre NHS Trust, Cardiff, UK,11Cardiff NCRI RTTQA group, Department of Medical Physics, Velindre Cancer Centre, Cardiff, UK,12University of Leeds, Leeds Cancer Centre , St James's University Hospital, Leeds UK,13Oncology Centre, Addenbrooke's Hospital, Cambridge, UK

Propensity Score-Matched Comparison of Focal High Intensity Focused Ultrasound (HIFU) to Laparoscopic Radical Prostatectomy (LRP) for Clinically Significant Localised Prostate Cancer

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Daniel Ball1,Na Hyun Kim1,Ashley McFarlane1,Taimur Shah2,Max Peters3,Enrique Gomez4,Saiful Miah2,Stephanie Guillaumier5,Naveed Afzai6,Tim Dudderidge7,Feargus Hosking-Jervis8,David Eldred-Evans8,Richard Hindley9,Henry Lewl10,Neil McCartan5,Caroline Moors5,Manit Arya11,Raj Nigam12,Chris Ogden13,Raj Persad14,Karishma Shah5,Jaspal Virdi15,Mark Emberton5,Hashim Ahmed16,Mathias Winkler16
1Imperial College Healthcare,2Imperial Health and Imperial College London (ICL),3University Medical Center Utrecht,4IMIBIC, University of Cordoba,5University College London,6Dorset County Hospital NHS trust,7University Hospital Southampton NHS Trust,8Imperial College London,9Basingstoke and North Hampshire Hospital,10Springfield Hospital,11Princess Alexandra Hospital, Harlow and UCLH NHS Trust,12Royal Surrey County Hospital,13Royal Marsden Hospital,14Southmead Hospital,15Princess Alexandra Hospital NHS Strust,16Imperial health and Imperial College London (ICL)

Results of CALIBER: A phase II randomised feasibility trial of chemoablation with MMC versus surgical management in low risk non-muscle invasive bladder cancer (NMIBC)

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Hugh Mostafid1,Joanne Cresswell2,Leyshon Griffiths3,John Kelly4,Allen Knight5,James Catto6,Kim Davenport7,Andrew Feber8,Margaret Knowles9,John McGrath10,Peter Cooke11,Shikohe Masood12,Aicha Goubar13,Steven Penegar13,Nuria Porta13,Laura Wiley13,Rebecca Lewis13,Emma Hall13
1Royal Surrey County Hospital NHS Foundation Trust,2South Tees Hospitals NHS Foundation Trust,3University Hospitals of Leicester NHS Trust,4University College London Hospital,5Consumer Representative,6University of Sheffield,7Gloucestershire Hospitals NHS Foundation Trust,,8University College London,9Leeds Institute of Cancer and Pathology,10Royal Devon and Exeter NHS Foundation Trust,11The Royal Wolverhampton Hospitals NHS Trust,12Medway NHS Trust,13Institute of Cancer Research

Pharmacophore-Based Virtual Screening for Identification of Human Helicase DDX3 Inhibitors

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Shailima Rampogu1,Ayoung Baek1,Minky Son1,Chanin Park1,Amir Zeb1,Keun Woo Lee1
1Gyeongsang National University

OPTIMA, a prospective randomised trial to validate the clinical and economic utility of tumour gene expression test use for prediction of chemotherapy sensitivity in high-risk early breast cancer

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Rob Stein1,Andreas Makris2,Luke Hughes-Davies3,Iain Macpherson4,Andrea Marshall5,Georgina Dotchin5,Peter Hall6,David Cameron6,Bjørn Naume7,Helena Earl8,Stuart McIntosh9,Sarah Pinder10,Jeremy Thomas6,Christopher Poole11,Daniel Rea12,John Bartlett13,Adrienne Morgan14,Leila Rooshenas15,Carmel Conefrey15,Jenny Donovan15,Claire Hulme16,Victoria Harmer17,Helen Higgins5,Janet Dunn5
1UCL,2Mount Vernon Cancer Centre, East and North Hertfordshoire NHS Trust,3Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust,4University of Glasgow,5University of Warwick,6University of Edinburgh,7Oslo University Hospital,8Cambridge University Hospitals,9Queen's University, Belfast,10King's College London,11University Hospitals Coventry and Warwickshire NHS Trust,12University of Birmingham,13Ontario Institute for Cancer Research MaRS Centre,14ICPV,15University of Bristol,16University of Leeds,17Imperial College Healthcare NHS Trust

Clinicopathological and functional significance of meiotic recombination 11 (MRE11) in epithelial ovarian cancers: A target validation study.

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Adel Alblihy1,Alabdullah Alabdullah1,Reem Ali1,Michael Toss1,Katia Almeida Masquita Almeida Masquita1,Emad A Rakha Rakha1,Srinivasan Madhusudan1
1University of Nottingham

Radium-223 treatment of Metastatic Castrate Resistant Prostate Cancer (mCRPC)- Audit of a new service at the Oxford University NHS Trust.

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Ami Sabharwal1,Emma Doyle2,Eliz Flanagan1,Jacqui Warden1,Darren Morgan1,Andrew Protheroe1,Phillip Camilleri3
1Oxford University Hospitals NHS Foundation Trust,2NHS Lothian,3Oxofrd University Hospitals NHS Foundation Trust

Quantification of tumour change during stereotactic ablative radiotherapy for non-small cell lung cancer

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Eleanor Clarke1,Matthew Beasley2,Richard Speight2,Louise Murray3
1University of Leeds,2Leeds Cancer Centre (St James's University Hospital),3Leeds Cancer Centre (St James's University Hospital), University of Leeds

Nanoparticle mediated LCS-1 delivery for the targeted therapy of BLM-deficient colorectal cancer cells

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Rehan Khan1,Anuradha Gupta1,Anas Ahmad1,Jayamurugan Govindasamy1
1Institute of Nano Science and Technology

SCOPE2: Randomised Phase II/III study of Definitive Chemoradiotherapy (dCRT) in Oesophageal Cancer Including PET Response and Dose Escalation

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Sarah Bridges1,Christopher Hurt1,Sarah Gwynne2,Jane Blazeby3,Simon Gollins4,Deborah Fitzsimmons-Warm5,Annmarie Nelson6,Ganesh Radhakrishna7,Timothy Maughan8,Hamid Sheikh7,Rajarshi Roy9,Andrew Bateman10,Stephen Falk11,Jane Heron4,Claire Heymann12,Bethan Tranter12,Emiliano Spezi13,Gareth Jones12,Kevin Bradley8,Christopher Marshall14,Stephen Thomas1,Lisette Nixon1,Somnath Mukherjee8,Maria Hawkins8,Tom Crosby12
1Centre For Trials Research, Cardiff University,2South West Wales Cancer Centre,3Centre For Surgical Research, University of Bristol,4North Wales Cancer Treatment Centre, Betsi Cadwaladr University Health Board,5Swansea Centre for Health Economics,6Marie Curie Palliative Care Research Centre, Cardiff University,7The Christie NHS Foundation Trust,8CRUK MRC Oxford Institute For Radiation Oncology, University of Oxford,9Queen’s Centre For Oncology and Haematology, Hull and East Yorkshire Hospitals NHS Trust,10Southampton Cancer Research UK Centre, University of Southampton,11Bristol Haematology and Oncology Centre, University Hospitals Bristol NHS Foundation Trust,12Velindre NHS Trust,13School of Engineering, Cardiff University,14Wales Research and Diagnostic PET Imaging Centre, Cardiff University

Downregulation of glycogen metabolism sensitises cancer cells to ionizing radiation via metabolic deregulation

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Christos E Zois1,Syed Haider2,Elisabete Pires3,Dimitra Kalamida4,Christoffer Lagerholm3,John Morris3,James Mccullagh3,Adrian Harris3
1Univeristy of Oxford,2ICR,3University of Oxford,4Democritus University of Thrace

Molecular characterisation of lung adenocarcinoma using a 22-gene panel: A United Kingdom tertiary cancer centre experience

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Kam Zaki1,Doraid Alrifai1,Danny Ulahannan1,Tanya Ahmad1,Dionysis Papadatos-Pastos1,Siow Ming Lee1,Charles Swanton1,Phil Bennett2,Mary Falzon1,Elaine Borg1,Neal Navani1,Sam Janes1,Martin Forster1
1University College London Hospitals NHS Foundations Trust,2Sarah Cannon Molecular Diagnostics

Is age a barrier to chemotherapy? Rates of treatment in older patients with breast, colon or lung cancer in England in 2013 to 2015: A national registry study.

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Michael Wallington1,Nicolo Matteo Luca Battisti2,Alistair Ring2,Sarah Payne3,Eva Morris4,Martine Bomb1,Jenny Seligmann4,Rebecca Birch4,Rebecca Smittenaar1,Tania Kalsi3,Luke Hounsome1,David Dodwell5,Stuart Underhill6,Lesley Mensah7,Peter Selby4,Janine Mansi3
1Public Health England,2The Royal Marsden NHS Foundation Trust,3Guy's and St Thomas'​ NHS Foundation Trust,4University of Leeds,5Leeds Cancer Centre/Institute of Oncology St James Hospital,6Roche,7Novartis Oncology

Cyclosporin A downregulates E2F8 in prostate cancer cells

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Soonbum Park1,Young Sik Kim1,Ju-Hong Jeon1
1Seoul national university

Immune checkpoint inhibitors are effective and well tolerated in elderly patients

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Shuai Zhang1,Ali Abdulnabi Mohamed2,Amit Samani3,Laura Spiers4,Zayd Tippu5,Sophie Merrick6,Miranda Payne7,Guy Faust8,Sophie Papa9,Debra Josephs9
1University Hospitals of Leicester NHS Trust,2University Hospitals of Leicester NHS Trust and Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom,3Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom;,4Oxford University NHS Foundation Trust, Oxford, United Kingdom,5King’s College London, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom,6Guy's and St Thomas' NHS Foundation Trust and King's College London, London, GB,7Oxford Cancer Centre, Oxford, United Kingdom;,8University Hospitals of Leicester NHS Trust, Leicester, United Kingdom;,9Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK

Clinical analysis of liver transplantation, and establishment and evaluation of nomogram models to predict liver graft quality

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Xi Yuan1,Yao Lu1,Zhiyong Guo2,Xiaoshun He2
1MOH Holdings Pte Ltd, Singapore,2Organ Transplantation Center, the First Affiliated Hospital of Sun Yat-sen University

Can texture analysis be used in cervical cancer to predict complete and partial responders to chemoradiotherapy?

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Sophie Otter1,Adrian Franklin1,Alexandra Stewart1
1Royal Surrey County Hospital

THE EFFECTS OF GERANIIN ON HUMAN BREAST CANCER CELL (MCF-7 AND MDA-MB-231) METABOLISM.

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Thenmaaran Palanisamy1,Dr. Kiruthiga Perumal2
1international Medical University,2International Medical University

Inhibition of Wnt/β-catenin signaling pathway by a small molecule against pancreatic cancer stem cells.

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Jayanta Das1,Mayur Doke1,Stanislaw Wnuk1,Marco Ruiz1,Jonathan Celli2
1FLORIDA INTERNATIONAL UNIVERSITY,2University of Massachusetts Boston

Bevacizumab in the treatment of platinum resistant ovarian cancer at the Edinburgh Cancer Centre (ECC)

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Amanda Swan1,Charlie Gourley1,Melanie MacKean1,Maria Sakala1,Alan Simms2,Tzyvia Rye1,Fiona Nussey1
1Edinburgh Cancer Centre,2Department of Radiology

POSNOC – Positive Sentinel Node: Adjuvant therapy alone versus adjuvant therapy plus clearance or axillary radiotherapy(ISRCTN54765244, Clinicaltrials.gov NCT02401685)

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Amit Goyal1
1Royal Derby Hospital

Developing new paradigms for overcoming drug resistance in cancer using novel humanised mouse models

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Colin Henderson1,Yury Kapelyukh1,Kenneth MacLeod2,De Lin1,Aileen McLaren1,Roland Wolf1
1University of Dundee,2Concept Life Sciences

Structure-based virtual screening identifies pranlukast as a CD49f antagonist that reduces stemness in MDA-MB-231 breast cancer cells

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Marco Velasco-Velazquez1,Inés Velázquez-Quesada1,Angel Ruiz-Moreno1,Diana Casique-Aguirre1,Charmina Aguirre-Alvarado1,Fabiola Cortés-Mendoza1,Marisol de la Fuente-Granada1,Mayra Pérez-Tapia2,Aliesha Gonzalez-Arenas1,Aldo Segura-Cabrera3
1National Autonomous University of Mexico,2National Polytechnic Institute,3EMBL-EBI

Analysis of putative biomarkers of resistance to retinoids in neuroblastoma cells and tumor tissue samples

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Viera Dobrotkova1,Petr Chlapek1,Katerina Adamkova2,Marta Jezova3,Pavel Mazanek3,Jaroslav Sterba3,Renata Veselska4
1Masaryk University, International Clinical Research Center, St. Anne’s University Hospital Brno,2Masaryk University,3University Hospital Brno, Masaryk University,4Masaryk University, International Clinical Research Center, St. Anne’s University Hospital Brno, University Hospital Brno, Masaryk University

Acid ceramidase expression and poor neoadjuvant responses in rectal cancer – is the modulation of apoptosis a key mechanism?

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Narendranath Govindarajah1,Rachael Clifford1,Paul Sutton1,David Bowden1,Dale Vimalachandran2,Jason L Parsons1
1University of Liverpool,2The Countess of Chester Hospital

Proteomic analysis of colorectal cancer cell resistance to 5-fluorouarcil and oxaliplatin reveals new mechanisms, prognostics markers and options for novel second line therapy

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Nadezda Dreize1,Algirdas Kaupinis1,Marija Ger1,Jonas Cicenas1,Arvydas Laurinavicius2,Mindaugas Valius1
1Proteomics Center, Institute of Biochemistry, Vilnius University Life Sciences Center, Vilnius,2National Center of Pathology, Affiliate of Vilnius University Hospital Santara Clinics, Vilnius

Comparing Continuous Hyperfractionated Accelerated Radiotherapy (CHART) and hypofractionated radiotherapy in non-small cell lung cancer – a retrospective study

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Wai-Yan Poon1,Philip McLoone1,Yvonne Flanagan1,David Keiller1,Suzanne Currie1,Stephen Harrow1
1Beatson West of Scotland Cancer Centre

A national snapshot of real-world combination checkpoint inhibitor induced immune-related colitis

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Anna Olsson-Brown1,S Subramanian2,C Connell3,P Corrie3,N Steven4,J Sacco1
1The Clatterbridge Cancer Centre NHS Foundation Trust and University of Liverpool,2The Royal and Broadgreen University Hospitals NHS Trust,3Cambridge University Hospitals NHS Foundation Trust,4Birmingham University Hospitals NHS Trust

Exploring the mechanism of action of a novel ent-kaurene diterpenoid for the treatment of colon cancer

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Md. Shahid Sarwar1,Yixuan Xia1,Ku Chuen Fai1,Siu Wai Tsang1,Man Shing Wong1,Hong-Jie Zhang1
1Hong Kong Baptist University

A Single Centre Study to Assess Outcomes and Toxicity Profiles in Patients with Non-Small Cell Lung Cancer Receiving Pembrolizumab Therapy

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Wing Kin Liu1,Stephen Robinson1,David Chao2
1North Middlesex Hospital,2Royal Free Hospital

CORINTH: A Phase 1b/II trial of Checkpoint Inhibitor (Pembrolizumab an anti PD-1 antibody) plus standard Chemoradiotherapy (CRT) in stage III Squamous Cell carcinoma (SCC) of the anus

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Martina Svobodova1,Marcia Hall2,Richard Adams1,Rob Glynne-Jones2,Sheela Rao3,Marianne Grønlie Guren4,Alexandra Gilbert5,Morny Drury6,Natalie Abbott7,Samuel Bosompem8,Lisette Nixon1,Charlotte Wilhelm-Benartzi1,Duncan Gilbert9,Vicky Goh10
1Centre for Trials Research, Cardiff University,2Mount Vernon Cancer Centre,3Royal Marsden Hospital,4Oslo University Hospital,5University of Leeds,6Patient Representative, Centre for Trials Research,7RTTQA, Velinder Cancer Centre,8London School of Hygiene and Tropical Medicine,9Royal Sussex County Hospital,10King's College London

Pimozide: An antipsychotic drug suppresses brain tumor growth by targeting STAT3 signaling.

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Itishree Kaushik1,Alok Ranjan2,Blake Schwettmann3,Sanjay Srivastava4
1Texas tech university health sciences center,2NIH Clinical Center (CC),3not known,4Texas Tech University Health Sciences Center

Discovery of anti-cancer effects of Pimavanserin tartrate in Pancreatic cancer

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Sharavan Ramachandran1,Sanjay Srivastava1
1Texas Tech University Health Sciences Center

Safety of outpatient management of cancer patients at risk of neutropenic sepsis using MASCC score at the Norfolk and Norwich University Hospital

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Ahmed Eltinay1,Gill Gray1,Ricky Fenn1,Saif Ahmad1
1Norfolk and Norwich University Hospital

Disulfiram reverses chemoresistance in pancreatic ductal adenocarcinoma (PDAC) by targeting hypoxia induced NF-KB pathway to eradicate cancer stem cell population

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Ogechi Nkeonye1,Ogechi Nkeonye1,Vinodh Kannappan1,Rajagopal Kilari1,Kate Butcher1,Karim Azar1,Mark Morris1,Christopher Heeschen2,Weiguang Wang1
1University of Wolverhampton,2Barts Cancer Institute

Ensartinib inhibits ABC drug efflux transporters and biotransformation enzymes and modulates pharmacokinetic multidrug resistance in vitro

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Dimitrios Vagiannis1,Martin Svoren1,Frantisek Staud1,Martina Ceckova1,Jakub Hofman1
1Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology

The use of pertuzumab for breast cancer patients in the neo-adjuvant setting presenting to a tertiary centre

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Gurvin Chander1,Daniel Rea1,Abeer Shaaban1,Mariam Jafri1
1University Hospitals Birmingham

Development of nano-enabled disulfiram reverses pan-chemoresistance by inhibiting hypoxia induced cancer stem cells in non-small cell lung cancer

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Kate Butcher1,Vinodh Kannappan2,Karim Azar2,Rajagopal Kilari2,Mark R Morris2,Christopher McConville3,Yaohe Wang4,Weiguang Wang2,Sathishkumar Kurusamy2
1Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton,2University of Wolverhampton,3University of Birmingham,4Queen Mary University of London

Patient recall of breast radiotherapy toxicities

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Alison Stillie1,Justin Geddes2,Hanlin Wong2,Kayla Duverger3,Ciaran Gunn2,Elizabeth Drinkwater2,Beth McConnell2,Samuel Fowler2
1NHS Lothian,2University of Edinburgh Medical School,3University of edinburgh

Feasibility and outcomes of craniospinal irradiation and concurrent daily carboplatin chemotherapy in children and adults with high risk CNS embryonal tumours, pineoblastoma and metastatic ependymoma

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Ramsay Singer1,Liam Welsh2,Fernando Carceller2,Sucheta Vaidya2,Joanna Stone2,Rupal Evans2,Ann Petruckevitch2,Ben O’Leary3,Stergios Zacharoulis2,Frank Saran2,Henry Mandeville2
1The Institute of Cancer Research,2The Royal Marsden Hospital, Sutton,3The Institute of Cancer Research, London

T-oligo mediates DNA damage responses by modulating telomere associated proteins and telomerase

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Zachary Schrank1,Nabiha Khan1,Joseph Kellen1,Sanjana Singh1,Chike Osude1,Neelu Puri1
1UIC College of Medicine Rockford

Long term aspirin treatment alters radiation sensitivity in colorectal cancer

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Eleanor Mortensson1,Adam Chambers2,Katherine Gash3,Rhys Morgan4,Michael Thomas3,Ann Williams1
1University of Bristol,2,3University Hospitals Bristol NHS Foundation Trust,4University of Sussex

Transcriptome-based identification of lovastatin as a breast cancer stem cell-targeting drug

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Marco Velasco-Velazquez1,Luz Vásquez-Bochm1,Mireya Velázquez-Paniagua1,Sandra Castro-Vázquez1,Sandra Guerrero-Rodríguez1,Abimael Mondragon-Peralta1,Mayra Pérez-Tapia2,Aliesha González-Arenas1
1National Autonomous University of Mexico,2National Polytechnic Institute

ICEC0942, a new oral selective inhibitor of the cell cycle and transcriptional regulator CDK7 for the treatment of breast and other cancers

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Simak Ali1
1Imperial College London