¹University of Cambridge, Cambridge, UK

¹King’s College London, London, UK

Cancer Research Institute, Seoul, Republic Of Korea

University of Sheffield, UK

¹Institute of Cell and Molecular Science, Queen Mary University of London, London, UK, ²Department of Materials /IRC in Biomedical Materials, Queen Mary University of London, London, UK, ³School of Biological and Chemical Sciences, Queen Mary University of London, London, UK, ⁴Centre for Experimental Cancer Medicine, Institute of Cancer, Queen Mary University of London, London, UK

Leeds Institute of Molecular Medicine, Leeds, West Yorkshire, UK

Cancer Research Technology Discovery Laboratories, University College London, London, UK

¹Cancer Research Technology Discovery Laboratories, University College London, London, UK, ²London Research Institute, London, UK

¹Cancer Institute, UCL, London, UK, ²London Centre of Nanotechnology, London, UK, ³Royal Free Hospital, London, UK

¹Northumbria University, Newcastle-upon-Tyne, UK, ²Manchester Metropolitan University, Manchester, UK, ³Newcastle University, Newcastle-upon-Tyne, UK

Northern Ireland Cancer Centre, Belfast, Northern Ireland, UK

Northern Ireland Cancer Centre, Belfast, Northern Ireland, UK

Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford Teaching Hospitals Foundation Trust, UK

Cancer Research UK, London, UK

¹Wellcome Trust Centre for Stem Cell Research, University of Cambridge, UK, ²The Hospital for Sick Children, University of Toronto, Canada

¹University of Oxford, UK, ²College of Biology & Food Engineering, Dalian Polytechnic University, China

¹Cranfield Health, Cranfield University, Bedfordshire, UK, ²Dept of Physiology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa, ³Dept of Surgery, Gloucestershire Royal Hospital, Gloucester, UK

University of Oxford, UK

¹University of Nottingham, UK, ²Washington University, St. Louis, USA

¹Medical Research Council, Edinburgh, Lothian, UK, ²Vanderbilt University, Nashville, USA

¹Imperial College London, London, UK, ²Centre for Cooperative Research in Biosciences, Bilbao, Spain

¹Cancer Research UK Cambridge Research Institute, University of Cambridge, UK, ²Max-Planck-Institute, Martinsried, Germany, ³Cambridge Systems Biology Centre, University of Cambridge, UK

Mercer University, Atlanta, USA

Medimmune, Cambridge, UK

Manchester Cancer Research Centre, Manchester, UK

¹Orexo AB, 754 50 Uppsala, Sweden, ²ProStrakan Group plc, Galashiels, TD1 1QH, UK

Cancer and Infection Research Area, Astrazeneca, Macclesfield, Cheshire, UK

¹Antisoma Research Ltd, Welwyn Garden City, Herts, UK, ²Betagenon AB, Umeå, Sweden

Northern Institute for Cancer Research, Newcastle upon Tyne, UK

Queen's University, Belfast, UK

¹Imperial College London, London, UK, ²Wolfson Brain Imaging Center, Cambridge, UK, ³Huddinge University Hospital, Stockholm, Sweden, ⁴Institute of Cancer Research Institute, Sutton, Surrey, UK

Astex Therapeutics, Cambridge, UK

¹Institute for Cancer Studies, University of Birmingham, Birmingham, UK, ²Institute of Biomedical Research, University of Birmingham, Birmingham, UK, ³Department of Urology, Queen Elizabeth Hospital, Birmingham, UK, ⁴Department of Pathology, Queen Elizabeth Hospital, Birmingham, UK

RAFT Institute, Middlesex, UK

University of Sheffield, Sheffield/South Yorkshire, UK

¹University of Sheffield, Sheffield, UK, ²University of Kent, Kent, UK, ³Keele University School of Medicine, Stoke on Trent, UK

Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK

¹University of Manchester, Manchester, UK, ²Paterson Institute for Cancer Research, Manchester, UK

¹Newcastle University, Newcastle upon Tyne, UK, ²L’Spallanzani National Institute for Infectious Disease, Rome, Italy

¹Division of Cancer studies, King's College London at Guy's Hospital, London, UK, ²Randall Institute, Division of Cell and Molecular Biophysics, King's College London at Guy's Hospital, London, UK, ³Division of Genetics and Molecular Medicine, King's College London at Guy's Hospital, London, UK

¹St James' Institute of Oncology, Leeds, UK, ²Cancer Research UK Academic Unit of Oncology, Leeds, UK

University College London, Royal Free Hospital, London, UK

Northern Institute for Cancer Research, Newcastle University, Newcastle, UK

¹The Adhesion and Angiogenesis Lab, 2 Centre for Tumour Biology, Cancer Research UK Clinical Centre, Institute of Cancer, Barts and The London School Of Medicine and Dentistry, John Vane Science Centre,, London, UK, ²Integrin Cell Biology Laboratory, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road,, Glasgow, UK, ³Cancer Research UK London Research Institute, Clare Hall Laboratories,, London, UK, ⁴Technologie Servier, 5 rue Bel Air, 45000 ,, Orléans, France, ⁵Institut de Recherches Servier (IdRS), Medicinal Chemistry Division, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France, ⁶Institut de Recherches Servier (IdRS), Cancer Drug Discovery Division, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France, ⁷Tumour Angiogenesis Group, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK

¹Institute of Cancer Research, Sutton, UK, ²Cambrodge University Hospitals NHS Foundation Trust, Cambridge, UK, ³Mount Vernon Hospital, Middlesex, UK, ⁴NHS, National, UK

University of Leeds, Leeds, UK

¹Mount Vernon Hospital, Northwood, Middlesex, UK, ²National Health Service (NHS), National, UK

Weston Park Hospital, Sheffield, UK

UCL Institute of Child Health, London, UK

Royal Marsden Hospital, London, UK