915 abstracts found.



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Systematic optimisation of in vivo imaging of αvβ6 in cancer

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Antonio Saha, David Ellison, Mather Stephen, Hart Ian, Marshall John

Queen Mary's, University Of London, London, UK


Variable breakpoints target PAX5 in patients with dicentric chromosomes; a model for the basis of unbalanced translocations in cancer

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Qian An1, Sarah Wright1, Zoë Konn1, Elizabeth Matheson2, Lynne Minto2, Anthony Moorman2, Helen Parker1, Mike Griffiths3, Fiona Ross4, Teresa Davies5, Andy Hall2, Christine Harrison2, Julie Irving2, Jon Strefford1

1Cancer Sciences Division, University of Southampton, Southampton, UK, 2Northern Institute for Cancer Research, University of Newcastle, Newcastle, UK, 3West Midlands Regional Genetics Laboratory, Birmingham Women’s Hospital, Birmingham, UK, 4Wessex Regional Genetic Laboratory, Salisbury District Hospital, Salisbury, UK, 5Bristol Genetics Laboratory, Southmead Hospital, Bristol, UK


HPV testing in combination with liquid-based cytology in primary cervical screening: a randomised trial

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Henry Kitchener1, Maribel Almonte2, Claire Thomson1, Alexandra Sargent1, Andrew Bailey3, Andrew Turner3, Chris Roberts1, Jean Mather3, Mina Desai3, Boyka Stoykova4, Sue Moss5, Julian Peto2

1University of Manchester, Manchester, UK, 2London School of Hygiene and Tropical Medicine, London, UK, 3Central Manchester and Manchester Children’s University Hospitals, Manchester, UK, 4Brunel University, Uxbridge, UK, 5Institute of Cancer Research, Sutton, Surrey, UK


Current methods of molecular imaging

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Mikael Pittet

Harvard Medical School, Boston, USA


Detailed constitutional epigenetic and copy number analysis of the 11p15 growth regulatory region in Wilms tumour by MS-MLPA

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Richard Scott, The Familial Wilms Tumour Collaboration, The Factors Associated with Childhood Tumours (FACT) Collaboration, Nazneen Rahman

Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK


Prospective assessment of the quality of surgery in the MRC CLASICC trial evidence for variation in the plane of surgery in colon cancer, local recurrence and survival

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Phil Quirke1, Helen Thorpe2, Sarah Dewberry2, Julia Brown2, David Jayne3, Pierre Guillou3, MRC Clasicc Trialists1

1Pathology and tumour biology, Leeds institute of Molecular Medicine, Leeds, West Yorkshire, UK, 2Clinical Trials Research Unit, Leeds institute of Molecular Medicine, Leeds, West Yorkshire, UK, 3Surgery, Leeds University, Leeds West Yorkshire, UK


Molecular imaging in early phase trials

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Susan Galbraith

Bristol-Myers Squibb, Princeton, USA


Molecular genetic and epigenetic analysis of paediatric low-grade gliomas

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Tim Forshew1, Ruth Tatevossian1, Steve Clifford2, David Ellison3, Denise Sheer1

1Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, UK, 2Northern Institute for Cancer Research, Newcastle University, Newcastle, UK, 3Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, USA


Long-term outcome of the first UKCCCR randomised trial of chemo-radiation for the treatment of epidermoid anal cancer

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Prof. Roger James1, Prof. John Northover2, Dr Rob Glynne-Jones3, Ms Helen Meadows4, Ms Susan Wan4, Mr Mark Jitlal4, Prof. Jonathan Ledermann4

1The Kent Oncology Centre, Maidstone, UK, 2St Mark's Hospital, Harrow, UK, 3Mount Vernon Hospital, Northwood, UK, 4Cancer Research UK and UCL Cancer Trials Centre, London, UK


Functional imaging applied to radiotherapy

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Ilja F Ciernik, J Bernard Davis, Gabor Szekely

Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland


NME1 and NME2 regulate activities of p53 and MDM2

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Radoslaw Polanski, Maria Maguire, Arpita Ray, Nikolina Vlatkovic, Mark Boyd

University of Liverpool, Liverpool, UK


The patient wants to see …

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Penny Wilson-Webb

Rarer Cancers Forum, UK


Inter-lesional variability of DCE-MRI response and changes in cardiac output following infusion of the vascular disruptive agent Combretastatin-A4-Phosphate (CA4P)

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Andrew Gaya1, N. Jane Taylor2, Tarun Mittal3, J James Stirling2, James d'Arcy4, D Koh4, Gordon Rustin1, Tim Meyer5, Paul Nathan1, David Collins4, Anwar Padhani2

1Mount Vernon Hospital, Northwood, Middlesex, UK, 2Paul Strickland Scanner Centre, Northwood, Middlesex, UK, 3Dept. Imaging, Harefield Hospital, Harefield, Middlesex, UK, 4CR-UK Imaging Group, Institute of Cancer Research, Sutton, Surrey, UK, 5Dept Medical Oncology, Royal Free Hospital, London,, UK


The transcriptional coactivator p68 regulates expression of novel p53 isoforms that are critical for transcriptional activation by p53

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Frances Fuller-Pace, Hayley Moore, Lee Jordan, Susan Bray, Lee Baker, Philip Quinlan, Alastair Thompson, Jean-Christophe Bourdon

University of Dundee, Dundee, UK


The regulator’s viewpoint

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Peter Littlejohns

National Institute for Health and Clinical Excellence (NICE), UK


Inhibition of ATM mediated DNA repair potentiates the cytotoxicity of DNA damaging ionising radiation in HCC cells

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Gary Beale1, Calvin Yu1, Graeme Smith2, Stephen Stewart3, Derek Manas3, Nicola Curtin1, Helen Reeves1

1Newcastle University, Newcastle-upon-Tyne, UK, 2Freeman Hospital, Newcastle-upon-Tyne, UK, 3KuDos Pharmaceuticals Ltd, Cambridge, UK


Informatics support for the discovery of new therapeutics

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John Overington

BioFocus DPI, London, UK


Regulation of miRNA processing in embryonic stem cells and cancer

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Richard Gregory

Children’s Hospital, Harvard University, USA


Androgen receptor function is regulated by histone demethylases: implication for prostate cancer

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Melanie Wissmann1, Na Yin1, Judith M Müller1, Holger Greschik1, Thomas Günther1, Nicolaus Friedrichs2, Reinhard Buettner2, Eric Metzger1, and Roland Schüle1

1>Universitäts-Frauenklinik und Zentrum für Klinische Forschung, Freiburg, Germany, 2Institut für Pathologie, University of Bonn, Germany


Information integration approaches to genomic data analysis

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John Quackenbush

Dana-Farber Cancer Institute, Boston, USA


MicroRNA regulatory networks

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Eric Miska

Wellcome Trust/CR-UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, UK


Validation of the estrogen related receptor as a therapeutic target in breast cancer

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Donald McDonnell

Duke University Medical Centre, Durham, USA


Defining workload and complexity in cancer clinical research

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James Lyddiard1, Jacqueline Briggs2, Mary Coffey3, Julie Berridge4

1University College London Hospitals NHS Foundation Trust, London, UK, 2Peninsula Stroke Research Network, Exeter, UK, 3Trinity College, Dublin, UK, 4Mid Trent Cancer Research Network, Nottingham, UK


Cancerous miRNAs and regulatory RNA binding proteins

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Netherlands Cancer Institute, Amsterdam, The Netherlands

MicroRNAs (miRNAs) are potent post-transcriptional regulators of protein coding genes. Patterns of mis-expression of miRNAs in cancer suggest key functions of miRNAs in tumourigenesis. However, current bioinformatics tools do not fully support the identification and characterization of the mode of action of such miRNAs.


Deregulation of RARγ and RARγ-specific miRNAs in acute myeloid leukaemia

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Angel Barrett1, Rajeev Gupta2, Louise Howell1, David Grimwade3, Marieke von Lindern4, Samuel Waxman5, Ken Mills6,7, Alan Burnett6, Tariq Enver2, and Arthur Zelent1

1>The Institute of Cancer Research, Sutton, UK, 2MRC Molecular Haematology Unit, John Radcliffe Hospital, Oxford, UK, 3Kings College London, UK, 4 Medical Centre (MC), Rotterdam, Netherlands 5Mount Sinai School of Medicine, New York, USA, 6University of Cardiff, Cardiff, UK, 7CCRCB, Queens University Belfast, Belfast, UK.


INSPIRE: An integrated web based informatics infrastructure for automated analysis of laboratory and clinical data

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Philip Roy Quinlan, Chris Reed, Lee Baker, Alastair Thompson

University of Dundee, Dundee, UK


MicroRNAs in childhood rhabdomyosarcoma

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Edoardo Missiaglia, Chris Shepherd, Sheena Patel, Janet Shipley

The Institute of Cancer Research, Sutton, UK


Role of PI3K signalling pathway in modulating hypoxia response in neuroblastoma

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Esther Bridges, Malin Åkerblom, Siv Beckman, Sven Påhlman

Lund University, Malmö, Sweden, Sweden


Modelling estrogen receptor alpha-positive breast cancer by transformation of normal human mammary epithelial cells

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Xenia Schmidt1, Stephan Duss2, Richard D Iggo1

1Bute Medical School, University of St Andrews, St Andrews, UK, 2Friedrich Miescher Institute (FMI), Basel, Switzerland


A national perspective on the surgical management and outcomes of colorectal cancer liver metastases

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Eva Morris1, David Forman1, James Thomas1, Phil Quirke1, Brian Cottier2, Graeme Poston3

1University of Leeds, Leeds, UK, 2National Cancer Services Analysis Team, Wirral, UK, 3University Hospital Aintree, Liverpool, UK


MicroRNA expression and profiling of bladder cancer

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Saiful Miah, Helen Owen, Stephane Larre, Ewa Dudziec, Ishtiaq Rehman, Freddie Hamdy, James Catto

Institute of Cancer Studies - University of Sheffield, Sheffield, UK


Financial impact of a cancer diagnosis for patients and their families: a qualitative study among oncology social workers and patients

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Aileen Timmons1, Linda Sharp1, Noeleen Donnelly2, Joan Kelly2, John Mccormack2, Niamh Ni Chonghaile2, Eileen O'donnell3, Olwyn Ryan2, Harry Comber1

1National Cancer Registry, Cork, Ireland, 2Irish Cancer Society, Dublin, Ireland, 3St Vincent's University Hospital, Dublin, Ireland


Non-invasive imaging of ER: coregulator interactions using luciferase fragment complementation

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Madryn Lake1, Quang-De Nguyen2, Simak Ali1, Eric Aboagye2

1Department of Oncology, Imperial College, London, UK, 2Molecular Therapy, Imperial College, London, UK


Characterisation and eradication of cancer stem cells in chronic myeloid leukaemia

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Tessa Holyoake

University of Glasgow, UK


RNA interference screen of the human Wnt signaling pathway

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Katja Seipel, Perihan Nalbant, Trevor Dale

Cardiff University, Cardiff, Wales, UK


DNA repair pathways as targets for therapeutics

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Graeme Smith

KuDOS Pharmaceuticals Ltd, Cambridge, UK


The role of Sox9 in prostate development and cancer

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Martin K. Thomsen, Amanda Swain

Section of Gene Function and Regulation, Institute of Cancer Research, London, UK


Mechanisms of resistance to endocrine therapies in breast cancer

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Simak Ali

Imperial College London, UK


Targeting DNA repair pathways in cancer therapeutics

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Alan D’Andrea

Dana-Farber Cancer Institute, Boston, USA


The multidisciplinary team in clinical trials: a Cancer Research UK training initiative

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Lesley Fallowfield

University of Sussex, Brighton, UK


MicroRNAs in development and cancer

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Frank Slack

Yale University, New Haven, USA


An oncogene-induced DNA replication stress model for human cancer development

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Omar Zgheib1, Ayguel Dereli1, Gwennaelle Versini1, Leandros Vassiliou2, Vassilis G Gorgoulis2, Thanos D Halazonetis1

1University of Geneva, Switzerland, 2University of Athens, Greece


Optimising decision-making in multi-disciplinary teams

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Jane Blazeby

University of Bristol, UK


Functional genomic annotation of microtubule stabiliser response defines chromosomal instability as a determinant of taxane sensitivity in vivo

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Charles Swanton1, Barbara Nicke1, Marion Schuett1, Aron Eklund4, Charlotte Ng2, Thomas Hardcastle2, Qiyuan Li4, Thomas Ried5, Gert Auer6, Jens Haberman8, Maik Kschischo7, Phil East1, Alvin Lee1, Zoltan Szallasi3, James Brenton2, Julian Downward1

1Cancer Research UK London Research Institute, London, UK, 2Cancer Research UK Cambridge Research Institute, Cambridge, UK, 3Harvard Medical School, Boston, USA, 4Technical University of Denmark, Lyngby, Denmark, 5NCI National Institute of Health, Bethesda, USA, 6Karolinska Institutet, Stockholm, Sweden, 7University of Applied Sciences, Remagen, Germany, 8University Hospital Schleswig-Holstein, Lubeck, Germany


DNA polymerase beta modulates sensitivity and resistance of colon cancer cells to oxaliplatin via DNA damage repair

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Jian Yang1, Jason Parsons1, Christopher F. Harrington2, Patrick G. Johnston3, W. Gillies McKenna1, Grigory L. Dianov1, Ricky A. Sharma1

1University of Oxford, Oxford, UK, 2Nottingham School of Science and Technology, Nottingham, UK, 3Queen's University, Belfast, UK


Improving the working lives of UK colorectal cancer teams: an evaluation of the Pelican team-based training programme

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Cath Taylor

Adamson Centre for Mental Health, St Thomas’ Hospital, UK


An FGFR inhibitor prevents chemoresistance in vitro and in vivo: a novel therapy for small cell lung cancer

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Olivier E. Pardo1, Claire Ashwin1, Gordon Stamp1, Nicholas Lemoine2, Michael J. Seckl1

1Imperial College London, London, UK, 2St Barts Hospital, London, UK


KU-0059436 plus radiation as first line therapy for glioblastoma multiforme: rationale and phase I clinical trial protocol

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Fiona Dungey1, Dana Loeser1, Anthony Chalmers2

1Genome Damage and Stability Centre, University of Sussex, Brighton, UK, 2Brighton and Sussex Medical School, Brighton, UK


The role of upper gastrointestinal multidisciplinary teams in recruiting patients into randomised controlled trials

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Clarisa TP Choh1, Angus McNair2, D Littlejohn2, SJ Falk1, Jane M Blazeby1

1United Bristol Healthcare Trust, Bristol, UK, 2University of Bristol, Bristol, UK


The use of Nutlin-3 as a radiosensitiser in laryngeal carcinoma cells harbouring wild-type p53

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Arvind Arya, Ashraf El-Fert, Timothy Devlin, Carlos Rubbi, Bryony Lloyd, John Fenwick, Terry Jones, Mark Boyd

University of Liverpool, Liverpool, Merseyside, UK