868 abstracts found.



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Micro-CT imaging for anatomical referencing in PET and SPECT: radiation dose, biological damage and image quality

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Veerle Kersemans,Philip Allen, Mick Woodcock, Mark Hill, Sean Smart

Gray Institute for Radiation Oncology and Biology, Oxford, UK


gH2AX: a target for imaging and systemic radiation therapy

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Bart Cornelissen, Kate Sleeth, Jody Mitchell, Sonali Darbar, Veerle Kersemans, Sean Smart, Katherine Vallis

Gray Institute for Radiation Oncology and Biology, University of Oxford, UK


Introduction: Research portrayal in the media

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Frances Balkwill

Barts and The London School of Medicine and Dentistry, UK


Hype, hope and hybrids: science, policy and media perspectives of the Human Fertilisation and Embryology Bill

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Nicholas Hillier

The Academy of Medical Sciences, London, UK


Seeing things from both sides

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Geoff Watts

Freelance science and medical writer and broadcaster, UK


Translation from abstract to media

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Ruth Francis

Nature Publishing Group, London, UK


Introduction: Senescence and autophagy as an approach to therapy

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Sharon Tooze

Cancer Research UK London Research Institute, UK


Autophagy in the control of tumour cell death

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Kevin Ryan

Beatson Institute for Cancer Research, Glasgow, UK


Lysosomal involvement in cell death and cancer

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Marja Jttel

Danish Cancer Society, Institute of Cancer Biology, Copenhagen, Denmark


FGFR3 mutation is not the initiating mutation in urothelial cell cancer

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Imran Ahmad1, Xue-Ru Wu2, Hing Y Leung1, Tomoko Iwata1, Owen J Sansom1

1Beatson Institute for Cancer Research, Glasgow, UK, 2New York University School of Medicine, USA


The role of the autophagy pathway in the development and maintenance of Myc-driven lymphoma

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John Cleveland

Scripps Research Institute, Jupiter, Florida


Identification of multiple genetic variants which predispose to prostate cancer by genome-wide association in the PRACTICAL international consortium

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Ros Eeles1, Zsofia Kote-Jarai1, Michelle Guy1, David Neal2, Freddie Hamdy3, Jenny Donovan4, Ali Amin Al Olama2, Doug Easton2, PRACTICAL Consortium1

1The Institute of Cancer Research, Sutton, UK, 2University of Cambridge, UK, 3University of Oxford, UK, 4Bristol University, UK


Autophagy in oncogene-induced senescence

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Masashi Narita

Cancer Research UK London Research Institute, UK


Sensitisation of hypoxic tumour cells through inhibition of PARP is oxygen dependent and correlates with decreased homologous recombination

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Zuzana Bencokova1, Norman Chan2, Isabel Pires1, Ponnari Gottipati1, Thomas Helleday1, Robert Bristow2, Ester Hammond1

1Gray Institute for Radiation Oncology and Biology, University of Oxford, UK, 2Princess Margaret Hospital (University Health Network) and Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Canada


Differential phosphoproteomics of fibroblast growth factor signalling: identification of Src-mediated phosphorylation events

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Debbie Cunningham1, Steve Sweet2, Helen Cooper1, John Heath1

1University of Birmingham, UK, 2University of Illinois at Urbana-Champaign, Urbana, USA


Mutant p53 regulates invasion via integrins and EGFR

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Patricia Muller1, Patrick Caswell1, Brendan Doyle1, Saadia Karim1, Owen Sansom1, Natalia Lukashchuk1, David Gillespie1, Pauline Gisselin2, Anne Cromer2, Marcin Iwanicki2, Joan Brugge2, Jim Norman1, Karen Vousden1

1The Beatson institute for Cancer Research, Glasgow, UK, 2Harvard Medical School, Boston, Massachusetts, USA


Downregulation of Disabled-2 switches TGF-beta from a tumour suppressor to a tumour promoter

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Adele Hannigan1, Lindsay Spender1, Blanca Herrera1, Darren O'Brien1, Xiang Zhang2, Reshma Shah3, Caroline Lord1, Tom Hamilton1, Margaret Frame4, Louise Hiller5, Milena Gasco6, Linda Nicholson7, Paul Smith3, Gabriela Kalna1, Meghan Maurer8, Jonathan Cooper8, Joan Massague2, Tim Crook3, Gareth Inman1

1The Beatson Institute for Cancer Research, Glasgow, UK, 2Memorial Sloan-Kettering Cancer Center, New York, USA, 3Breakthrough Breast Cancer, London, UK, 4The Edinburgh Cancer Centre, Edinburgh, UK, 5University of Warwick, Warwick, UK, 6Sant Croce General Hospital, Cuneo, Italy, 7Kings College London School of Medicine, London, UK, 8Fred Hutchinson Cancer Research Center, Seattle, USA


A genome-wide association study identifies a novel ovarian cancer susceptibility locus on chromosome 9p22

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Simon Gayther1, Honglin Song2, Susan Ramus1, Jonathan Tyrer2, Kelly Bolton2, Aleksandra Gentry-Maharaj1, Eva Wozniak1, Ian Jacobs1, Usha Menon1, Douglas Easton3, Paul Pharoah2, Ovarian Cancer Association Consortium4

1UCL EGA Institute for Womens Health, University College London, UK, 2University of Cambridge, Strangeways Research Laboratory, Cambridge, UK, 3CR-UK Genetic Epidemiology Unit, Cambridge, UK, 4The Comprehensive Cancer Center, Duke University Medical Center, Durham, USA


ADAM-17 is a key regulator of ErbB survival response in colorectal cancer

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Joan Kyula, Sandra Van Schaeybroeck, Daniel Longley, Patrick Johnston

Queen's University, Belfast, UK


Fbxw7 (hCDC4) E3- Ubiquitin Ligase Receptor: lineage potential and its commitment to cancer

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NingNing Li1, Ranjith Muraleedharan1, Ke Wang1, Amir Ghaemmaghami1, Anas Saadeddin1, Bradley Spencer-Dene2, Sue Watson1, Abdolrahman Shams Nateri1

1University of Nottingham, UK, 2London Research Institute, Cancer Research UK, Nottingham, UK


Title to be confirmed

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Speaker to be confirmed

Affiliation to be confirmed


Introduction: Prostate and bladder cancer

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Noel Clarke

Christie NHS Foundation Trust, Manchester, UK


Screening for prostate cancer

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Freddie Hamdy

University of Oxford, UK


Genome-wide characterisation somatic mutations in cancer

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Andy Futreal

Wellcome Trust Sanger Institute, Hinxton, UK


The management of high risk localised prostate cancer

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David Dearnaley

The Institute of Cancer Research, Royal Marsden Hospital, Sutton, UK


Hepatocellular cancer and genomes

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Bruno Clement

Institut National de la Sant et de la Recherche Mdicale (INSERM), France


Surgical and oncological outcomes following cystectomy for transitional cell cancer

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Vijay Ramani

Christie NHS Foundation Trust, Manchester, UK


Comprehensive cancer genome characterisation by sequencing

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Stacey Gabriel

Broad Institute, Massachusetts Institute of Technology, Cambridge, USA


Techniques for bladder preservation for muscle invasive bladder cancer

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Richard Cowan

Christie NHS Foundation Trust, Manchester, UK


High resolution array Comparative Genomic Hybridization (aCGH) of breast carcinoma identifies Mouse Double Minutes 4 (Mdm4) as one of the early genetic changes in breast cancer development: Mdm4 is a new independent prognostic and predictive marker

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Tarek M.A. Abdel-Fatah1, Des G. Powe1, Maryou Lambros3, Jorge S. Reis-Filho3, Ian O Ellis1

1School of Molecular Medical Sciences and Nottingham University Hospitals Trust, University of Nottingham, UK, 2National Liver Institute, Menoufyia University, Menoufyia, Egypt, 3Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK


Novel Biomarkers and Therapeutics for castration-resistant prostate cancer (CRPC)

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Gert Attard

Drug Development Unit, Institute of Cancer Research, Royal Marsden Hospital, Surrey, UK


Analysis of copy number alterations in familial and sporadic clear cell renal cell carcinoma with high resolution SNP arrays

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Salwati Shuib1, Eleanor Rattenberry2, Dominic McMullan2, Mark Morris1, Chris Ricketts1, Patrick Maxwell3, Farida Latif1, Eamonn Maher1

1University of Birmingham, UK, 2West Midlands Regional Genetics Laboratory and Clinical Genetics Unit, Birmingham Women's Hospital, UK, 3University College London, UK


A transcriptomic and genomic investigation into taxane resistant breast cancer

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Juliet Kenicer1, Maryou Lambros2, Vicky Sabine1, Jorge Reis Filho2, John Bartlett1

1Edinburgh Cancer Research Centre, The University of Edinburgh, Edinburgh, Lothian, UK, 2The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, London, UK


Image based pathway analysis of FOXO regulation leads to the discovery of therapeutic targets and small molecule inhibitors for anticancer therapy

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Wolfgang Link, Amancio Carnero, Fabian Zanells

Spanish National Cancer Centre (CNIO), Madrid, Spain


Identification and characterisation of small molecule inhibitors of phosphatidylinositol-4-phosphate 5-kinase

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Sylvie Lachmann1, Sarah Griffiths1, Oliver Kern1, James Smith1, Tracey Hunter1, Mar Jimenez Quesada1, Laura Bill1, Jon Roffey1, Elisabeth Trivier1, Robert Wood1, Ai Ching Wong1, Louise Tonkin1, Marc Pittman1, Leon Pang1, Tim Hammonds1, Caroline Foxton1, David R Jones2, Nullin Divecha2, Martin Swarbrick1, Iris Treinies1

1Cancer Research Technology Discovery Laboratories, London, UK, 2Inositide Laboratory, Paterson Institute for Cancer Research, Manchester, UK


Introduction: Colorectal cancer

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Bob Steele

Ninewells Hospital and Medical School, Dundee, UK


Optimising population screening for colorectal cancer

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Graeme Young

Flinders University, Adelaide, Australia


Colorectal cancer screening: an underdeveloped opportunity for promoting lifestyle change?

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Annie Anderson

University of Dundee, UK


Adenoma prevention trials – where next?

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Richard Logan

University of Nottingham, UK


Genomic profiling of B-progenitor acute lymphoblastic leukaemia

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Charles Mullighan

St Jude Children's Research Hospital, Memphis, USA


The fraction of colorectal cancer attributable to lifestyle and environmental factors in the UK in 2005

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Donald Maxwell Parkin, Anne Helen Olsen, Peter Sasieni

Queen Mary University of London, LUK


The impact of cytogenetic and molecular information on decision making in AML

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Alan Burnett

Cardiff University, UK


Inequalities in colorectal cancer screening participation: a neighbourhood- level analysis of inner and outer London areas

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Christian von Wagner1, Anna Good1, Dennis Wright4, Bernard Rachet2, Austin Obichere3, Stuart Bloom3, Jane Wardle1

1University College London, UK, 2London School of Hygiene and Tropical Medicine, UK, 3University College London Hospital, UK, 4Northwest London Hospital Trust, UK


Prediction of HLA-DRB1-restricted CD4+ T cell epitopes in the childhood ALL-associated TEL-AML1 fusion oncoprotein: population coverage, and design of heteroclitic peptides

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Shobha Kudva, Pamela Thompson, Adiba Hussain, Malcolm Taylor

University of Manchester, UK


Factors affecting attitudes towards colorectal cancer screening in the primary care population

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Taina Taskila1, Sue Wilson1, Sarah Damery1, Andrea Roalfe1, Val Redman1, Tariq Ismail2, Richard Hobbs1

1Primary Care Clinical Sciences, University of Birmingham, UK, 2University Hospital Birmingham Foundation NHS Trust, Queen Elizabeth Hospital, UK


Targeted radiotherapy with an anti-CD66 monoclonal antibody prior to haematopoietic stem cell transplantation: therapy intensification without toxicity

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Kim Orchard1, Maggie Cooper2, Maria Tristam1, Jon Langford3, Louise Causer1, James Thom1, Amanda Watson4, Maureen Zivanovic1, Deborah Richardson1, Peter Johnson4

1Southampton University Hospital Trust, UK, 2St Bartholemews Hospital, London, UK, 3University of Southampton, UK, 4Cancer Sciences School of Medicine, Southampton, UK


Introduction: High throughput sequencing and cancer genomes

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Andy Futreal

Wellcome Trust Sanger Institute, Hinxton, UK


Genome-wide epigenetic analysis of childhood acute lymphoblastic leukaemia

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Thomas Dunwell1, Luke Hesson1, Tibor Rauch2, Daniel Catchpoole3, Eamonn Maher1, John Minna4, Gerd Pfeifer2, Farida Latif1

1University of Birmingham, UK, 2City of Hope, Duarte, USA, 3Children's Hospital at Westmead, Australia, 4University of Texas, USA


Introduction: Anti-cancer drug discovery

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Ian Collins

The Institute of Cancer Research, Sutton, UK


Diversity oriented synthesis based on natural product scaffolds

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Nicolas Winssinger

Universit Louis Pasteur, Strasbourg, France