826 abstracts found.



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Disulfiram – an old antialcoholism drug tackling cancer stem cells to sensitize breast cancer cells to conventional anticancer drugs

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Nga C Yip1, Ivo S Fombon1, Peng Liu1, Sarah Brown1, Vinodh Kaannappan1, Angel L Armesilla1, John L Darling1, James Cassidy2, Weiguang Wang1
1University of Wolverhampton, Wolverhampton, United Kingdom,2University of Glasgow, Glasgow, United Kingdom

Disulfiram sensitised cytotoxicity of gemcitabine in human glioblastoma cell lines

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Sarah Brown1, Peng Liu1, Tuge Goktug1, Prasanna Channathodiyil1, John L Darling1, Weiguang Wang1
1University of Wolverhampton, Wolverhampton, United Kingdom

Comparison of Human Papillomavirus Infections in gynecological cancers among Pakistani women

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Noureen Khan1, Chihaya Koriyama1, Suminori Akiba1
1Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan., Kagoshima, Japan

Predicting Risk Of Cancer At Screening (PROCAS): results on the first 10,000 women entered from the Greater Manchester National Breast Screening Programme (NHSBSP)

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Gareth Evans1, Paula Stavrinos2, Sue Astley3, Mary Wilson2, Alan Hufton3, Jane Warwick4, Ruth Warren5, Michelle Harvie2, Barbara Eckersley2, William Newman3, Iain Buchan3, Jack Cuzick4, Anthony Howell6
1Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom,2University Hospital of South Manchester, Manchester, United Kingdom,3University of Manchester, Manchester, United Kingdom,4Wolfson Institute of Preventive Medicine, London, United Kingdom,5University of Cambridge, Cambridge, United Kingdom,6Christie Hospital, Manchester, United Kingdom

Evidence of an infectious aetiology for teenage and adult cancers – an analysis of seasonality of birth

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Richard Feltbower1, Marlous Van Laar1, Sally Kinsey2, Susan Picton2, Antony Moran3
1University of Leeds, Leeds, United Kingdom,2Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom,3North West Cancer Intelligence Service, Manchester, United Kingdom

Breast cancer and age in ethnic groups in South East England

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Ruth Jack1, Elizabeth Davies1, Henrik Møller1
1King's College London, London, United Kingdom

Cytogenetic abnormalities associated with p53 mutation in primary breast cancers

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Jasbani Dayal1, Norman Pratt1, Mark Sales1, Colin Purdie1, Philip Quinlan1, Lee Baker1, Michael Boylan1, Gordon Hislop1, Natalja Terhaar2, Willem Corver2, Alastair Thompson1
1University of Dundee, Dundee, United Kingdom,2Leiden University Medical Centre, Leiden, Netherlands

“Trends in cancer incidence among South Asians in England, 1986-2004”

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Camille Maringe1, Punam Mangtani1, Bernard Rachet1, Nicola Cooper2, Michel P Coleman1, Isabel Dos Santos Silva1
1LSHTM, London, United Kingdom,2NCIN, London, United Kingdom

Gain of 16p11.2 region associates with oestrogen receptor and progesterone receptor positive status in primary breast cancer.

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Jasbani Dayal1, Mark Sales1, Colin Purdie1, Lee Baker1, Philip Quinlan1, Michael Boylan1, Willem Corver2, Natalja Terhaar2, Norman Pratt1, Alastair Thompson1
1University Of Dundee, Dundee, United Kingdom,2Leiden University Medical centre, Leiden, Netherlands

Genome-wide association study identifies a novel breast cancer susceptibility locus

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Gillian Ross1, Olivia Fletcher2, Nicola Johnson2, Nick Orr2, Fay Hoskings2, Lorna Gibson3, K Walker2, Diana Zelenika5, Stephen Chanock6, S Heath1, David Hunter5, Ben Coupland2, Peter Broderick2, Minouk Shoemaker2, Michael Jones1, Sarah Chilcott-Burns1, Mark Lathrop7, Richard Houlston2, Alan Ashworth2
1Royal Marsden Hospital, London, United Kingdom,2Institute of Cancer Research, London, United Kingdom,3London School of Hygiene and Tropical Medicine, London, United Kingdom,4Welcome Trust for Human Genetics, Cambridge, United Kingdom,5Molecularand Genetic Epidemiology, Harvard, United States,6National Institure of Health, Bethesda, United States,7Centre National de Genotypage, Paris, France

Significant cytogenetic change associated with the der(1;16) rearrangement in primary breast cancers.

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Jasbani Dayal1, Mark Sales1, Lee Baker1, Philip Quinlan1, Colin Purdie1, Michael Boylan1, Joan Cunningham1, Willem Corver2, Natalja Terhaar2, Norman Pratt1, Alastair Thompson1
1University Of Dundee, Dundee, United Kingdom,2Leiden University Medical Centre, Leiden, Netherlands

Does the presence of endometriosis alter the behaviour of clear cell carcinoma?

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Jatinder Kaur1, Thomas Ind1, Desmond Barton1, John Shepherd1, Jane Bridges1
1Royal Marsden Hospital, London, United Kingdom

Structure-Activity Relationship study of inhibitors of Eg5 –- a drug target for cancer chemotherapy

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Kristal Kaan1, Johanna Weiss2, Dominik Menger2, Venkatasubramanian Ulaganathan1, Katarzyna Tkocz1, Christian Laggner4, Florence Popowycz3, Benoît Joseph3, Frank Kozielski1
1The Beatson Institute for Cancer Research, Glasgow, United Kingdom,2University Hospital Heidelberg, Heidelberg, Germany,3Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Villeurbanne, France,4University of Innsbruck, Innsbruck, Austria

Epidemiology of bladder cancer in Setif, Algeria

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Z. Zaidi1, A. Saada2, A. Dib2, D. Abdellouche3, A. DjemaDjazia4, M. Abdoun1, S. Laouamri1, A. Mahnane1, M. Hamdi Cherif1
1Cancer Registry of Setif- University Hospital of Setif, Setif, Algeria,2Department of Urology - University Hospital of Setif, Setif, Algeria,3Anatomopathology department - University Hospital of Setif, Setif, Algeria,4Constantine Anti-cancer center- University Hospital of Constantine, Constantine, Algeria

Utilising the General Practitioner in assessing fitness for chemotherapy: a pilot study. 

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Sophie Otter1, Duncan Gilbert1
1Royal Sussex County Hospital, Brighton, United Kingdom

Efficacy of infiltration of local anaesthetic for pain relief after total mastectomy

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Samy Shaheed1, Charles Zammit1
1Breast Unit, Brighton and Sussex University Hospitals NHS Trust, Brighton, East Sussex, United Kingdom

“Synthesis and biological evaluation of thymoquinone derivatives and ON01910 derivatives as anticancer agents”

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Osama Chahrour2, Liu Xiangrui1, Lam Franki1, Ashraf Abdallah1, Carol Midgley3, Wang Shudong1
1University of Nottingham, Nottingham, United Kingdom,2University of Damascus, Damascus, Syrian Arab Republic,3The Open University, Milton Keynes, United Kingdom

Melanoma cell migration in vitro can be blocked in a modified Boyden chamber assay using the anti-angiogenic endogenous sister isoform VEGF165b.

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Daemon Dewing1, Maxine Emmett1, Paul McArthur1, Rowan Pritchard Jones1
1University of Liverpool, Merseyside, United Kingdom

Tetraspanin CD 151 is a novel prognostic marker in poor outcome endometrial cancer

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Martin Voss3, Naheema Gordon1, Raji Ganesan2, Linmarie Ludeman4, Keith McCarthy4, Robert Gornall3, Wenbin Wei1, Fedor Berditchevski1, Sudha Sundar1
1School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom,2Department of Pathology, Birmingham Womens Hospital, Birmingham, United Kingdom,3Department of Obstetrics and Gynaecology, Cheltenham General Hospital, Cheltenham, United Kingdom,4Department of Pathology, Cheltenham General Hospital, Cheltenham, United Kingdom

A comparative investigation of the perfusion of spontaneous and transplanted pancreatic ductal adenocarcinoma (PDA) tumours in genetically engineered mice by dynamic contrast-enhanced MRI

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Leanne Bell1, Davina Honess1, Dominick McIntyre1, David Tuveson1, John Griffiths1
1Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom

The combination of AZD8055 and selumetinib (AZD6244, ARRY-142886) is synergistic in a subset of non small cell lung cancer cell lines with co-dependancy to the MEK and mTOR pathways.

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Zoe Howard1, Jonathan Dry1, Gayle Marshall1, Nicola Curtis1, Sylvie Guichard1, Paul Smith1
1AstraZeneca, Cheshire, United Kingdom

In utero low protein diet enhances estrogen exposure effects on adult rat prostate

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Jaqueline Rinaldi1, Carolina Sarobo1, Livia Lacorte1, Flavia Delella1, Andrei Moroz1, Andrelson Rinaldi2, Luis Justulin Jr1, Sergio Felisbino1
1Univ Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil,2Universidade Federal da Grande Dourados (FACET), Faculdade de Ciências Exatas e Tecnológicas, Dourados, MS, Brazil

Identification of markers that discriminate between cervical cancer subtypes in formalin-fixed paraffin-embedded (FFPE) tissues

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John Hall1, Hui Sun Leong2, Crispin Miller2, Catharine West1
1Translational Radiobiology Group, The Paterson Institute for Cancer Research, Manchester, United Kingdom,2Applied Computational Biology and Bioinformatics Group, The Paterson Institute for Cancer Research, Manchester, United Kingdom

Oncotype Dx in early breast Cancer: first UK prospective trial.

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Gianfilippo Bertelli1, Delia Pudney1, Martin Rolles1, Maung Moe1, Elaine Brinkworth1, Sian Whelan2, Sarah Khawaja2, Simon Holt1
1Singleton Hospital, Swansea, United Kingdom,2Prince Philip Hospital, Lanelli, United Kingdom

Metabolomic characterisation of stem-like glioblastoma cell lines

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Sara Dietz1, Madhu Basetti1, Colin Watts2, John Griffiths1
1Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom,2Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom

SHOX2 DNA methylation – validation of a lung cancer biomarker in bronchial lavage

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John Field1, Dimo Dietrich2, Christoph Kneip2, Olaide Raji1, Triantafillos Liloglou1, Anke Seegebarth2, Thomas Schlegel2, Nadja Flemming2, Sebastian Rausch2, Juergen Distler2, Michael Fleischhacker3, Volker Liebenberg4, Thomas Giles5, Martin Walshaw5, Chris Warburton6, Bernd Schmidt7
1The University of Liverpool, Liverpool, United Kingdom,2Epigenomics AG, Berlin, Germany,3Charite-Universitatsmedizin, Berlin, Germany,4Metanomics Health GmbH, Berlin, Germany,5Royal Broadgreen University Hospital Trust, Liverpool, United Kingdom,6Aintree University Hospital Trust, Liverpool, United Kingdom,7Universitaetsklinikum Halle- Saale, Halle, Germany

FOxTROT: randomised phase 2/3 study of neoadjuvant chemotherapy (CT) ± an anti-EGFR monoclonal antibody for locally advanced, operable colon cancer

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Dion Morton1, Gina Brown2, David Ferry3, Richard Gray4, Laura Magill4, Phil Quirke5, Matt Seymour5, Bryan Warren6
1The Queen Elizabeth Hospital, Birmingham, United Kingdom,2The Royal Marsden Hospital, London & Surrey, United Kingdom,3New Cross Hospital, Wolverhampton, United Kingdom,4The University of Birmingham, Birmingham, United Kingdom,5University of Leeds, Leeds, United Kingdom,6The John Radcliffe Hospital, Oxford, United Kingdom

Controlled activation of platinum(IV) prodrugs to active cytotoxics for photochemotherapy

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Kim Robinson2, Julie Woods2, Nicky Farrer1, Ana Pizarro1, Fiona Mackay3, Viv Munk3, Peter Sadler1
1Department of Chemistry, University of Warwick, Coverntry, United Kingdom,2Photobiology Unit, Department of Dermatology, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom,3School of Chemistry, University of Edinburgh, Edinburgh, United Kingdom

“Eukaryotic initiation factor 4E phosphorylation status and 4E binding protein 1 expression in skin squamous cell carcinoma”

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Farhad Mashayekhi1, Zivar Salehi1
1Islamic Azad University, Tonekabon, Iran, Islamic Republic of

BIOPROP: Biologically Optimised Prostate Cancer Radiotherapy or Dose Painting

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Isabel Syndikus1, Julien Uzan1, Philip Mayles1, Alan Nahum1
1Clatterbridge Centre for Oncology, Bebington, Merseyside, United Kingdom

“Association of vascular endothelial growth factor gene polymorphism with the risk of non-small-cell lung cancer in an Iranian population”

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Farhad Mashayekhi1, Zivar Salehi1
1Islamic Azad University, Tonekabon, Iran, Islamic Republic of

Role of NF-KAPPA B in cell fate  decisions in neuroblstoma

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Dhanya Mullassery1, Violaine See3, Dave Spiller3, Barry Pizer2, Carlo Dominici4, Heather McDowell2, Edwin Jesudason1, Paul Losty1, Mike White3
1Academic paediatric Surgery, University of Liverpool, Liverpool, United Kingdom,2Paediatric Oncology, Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom,3Centre for Cell Imaging, University of Liverpool, Liverpool, United Kingdom,4Department of Paediatrics, La Sapienza University, Rome, Italy

The TFF1 promoter polymorphism and risk of gastric cancer

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Maryam Rasekhi1, Mehdi Moghanni bashi2, Parisa Mohamadynejad2, Mohammad Mohammadian Panah3, Abbas Ghaderi4, Saeed Khatamsaz2
1Islamic Azad university Arsanjan branch, Arsanjan/shiraz, Iran, Islamic Republic of,2Islamic Azad university Kazerun branch, kazerun/shiraz, Iran, Islamic Republic of,3Department of radiation oncology Namazi hospital Shiraz University of Medical sciences, Shiraz, Iran, Islamic Republic of,4Shiraz institute for cancer research Shiraz University of medical sciences, Shiraz, Iran, Islamic Republic of

The histone demethylase, JMJD2B, as a potential therapeutic target in prostate cancer

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Kelly Armstrong1, Lynsey Rogerson1, Dhuha AlKaraif1, Jacqueline Stockley1, Luke Gaughan1, Craig Robson1
1Newcastle University, Newcastle upon Tyne, United Kingdom

An analysis of ASPP protein expression in prostate cancer.

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Lucia Cerundolo1, Emma Morris1, Florian Fritzsche2, Stephane Larre1, George Thalmann3, Freddie Hamdy1, Xin Lu2, Richard Bryant1
1Nuffield Department of Surgical Sciences, University of Oxford,, Oxford, United Kingdom,2Ludwig Institute for Cancer Research Ltd, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom,3Department of Urology, University of Bern, Bern, Switzerland

Heterogeneity of gross chromosomal abnormalities in uveal melanoma with extraocular extension detected by multiplex ligation-dependent probe amplification

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Sarah L. Lake1, Bertil E. Damato2, Justyna Dopierala1, Azzam F.G. Taktak3, Sarah E. Coupland1
1Pathology Department, School of Cancer Studies, University of Liverpool, Liverpool, United Kingdom,2Ocular Oncology Service, St Paul’s Eye Clinic, Royal Liverpool University Hospital, Liverpool, United Kingdom,3Department of Medical Physics and Clinical Engineering, Royal Liverpool University Hospital, Liverpool, United Kingdom

Ablation of adipose triglyceride lipase (ATGL) protects from cancer associated cachexia

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Suman Das1, Paul Vesely1, Silvia Schauer1, Guenter Haemmerle2, Clemens Diwoky3, Hannes Temmel1, Sandra Eder2, Robert Zimmermann2, Rudolf Zechner2, Gerald Hoefler1
1Institute for Pathology, Medical University of Graz, Graz, Austria,2Institute of Molecular Biosciences, University of graz, Graz, Austria,3Institute of Medical Engineering,Graz University of Technology, Graz, Austria

The role of KAP-1 in hypoxia

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Monica Olcina1, Ester Hammond1
1University of Oxford, Oxford, United Kingdom

PTEN regulates apoptosis via Cdc42/ JNK/GSK3? in colon cancer cells.

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Aliya Fatehullah1, Ravi Deevi1, Ishaan Jagan1, Victoria Bingham1, Mahalakshmi Nagaraju1, Frederick Charles Campbell1
1Centre for Cancer Research and Cell Biology, Belfast, United Kingdom

Understanding the phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks):  A way of PIPping cancer to the post?

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Daniel Fitzgerald1, Nullin Divecha1
1The Paterson Institute for Cancer Research, Manchester, United Kingdom

Expression of lamin A in colorectal cancer cells can induce epithelial-mesenchymal transition

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Clare Foster1, Naomi Willis1, Joanne Robinson1, Thomas Cox1, Danielle Battle1, Daniel Swan2, Robert Wilson3, Christopher Hutchison1
1Durham University, Durham, United Kingdom,2Newcastle University, Newcastle, United Kingdom,3James Cook University Hospital, Middlesborough, United Kingdom

TTC5, a TPR Motif co-factor required for myeloid leukaemogenesis

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James Lynch1, Tim Somervaille1
1Cancer Research UK, Leukaemia Biology Laboratory, Paterson Institute for Cancer Research, The University of Manchester, Manchester, United Kingdom

Structural basis of poly(ADP-ribose) recognition by the multi-zinc binding domain of checkpoint with forkhead-associated and RING domains (CHFR)

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Jasmeen Oberoi1, Mark Richards1, Simon Crumpler2, Nathan Brown2, Julian Blagg2, Richard Bayliss1
1Section of Structural Biology, The Institute of Cancer Research, London, United Kingdom,2CR-UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, United Kingdom

THE APPLICATION OF NEXT-GEN SEQUENCING IN CANCER RESEAERCH

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Yingrui Li1, Wangting Chen1, Ruiqing Li1
1BGI, Shenzhen, China

Canonical and non-canonical Wnt signaling pathways control the stem-like behavior of human gliomas

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Teodoro Pulvirenti1, Maartje Van Der Heijden2, Viviane Tabar2, Alan Hall1
1Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, United States,2Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, United States

Thirty-day post-operative mortality after colorectal cancer surgery in England

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Eva Morris1, Faye Taylor1, James Thomas1, Phil Quirke1, Paul Finan1, Michel Coleman2, Bernard Rachet2, David Forman1
1University of Leeds, Leeds, United Kingdom,2London School of Hygiene and Tropical Medicine, London, United Kingdom

LKB regulates cdc42 activity in a STRAD dependent pathway.

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Ravi Deevi1, Ishaan Jagan1, Aliya Fatehullah1, Victoria Bingham1, Frederick Charles Campbell1
1Centre for Cancer Research and Cell Biology, Belfast, United Kingdom

The consequences of tetraploidy in mammalian cells

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Kuan-Chung Su1, Mark Petronczki1
1CRUK LRI, Potters Bar, United Kingdom

The effect of elongation factor 1 alpha eEF1A on the organisation of polymerised actin filaments

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Annette Doyle1, Mark Murphy1, Mark Murphy1, R Crosby1
1School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom

MicroRNAs regulating CCN3 expression in Chronic Myeloid Leukaemia

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Sukanya Suresh1, Lynn McCallum1, Sandra Irvine1
1Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom