826 abstracts found.



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Characterising the mechanical properties of normal and cancer prostate cells using atomic force microscopy.

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Greg Madden1, Gary Johnston1, Mark Murphy2, Francis Lilley1, David Burton1
1Liverpool John Moores University - General Engineering Research Institute, Liverpool, United Kingdom,2Liverpool John Moores University - Pharmacy Biomolecular Sciences, Liverpool, United Kingdom

The glycomic analysis of melanoma cells at different stages of progression.

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Pawel Link-Lenczowski1, Terry D. Butters2, Anna Litynska1
1Jagiellonian University, Institute of Zoology, Department of Glycoconjugate Biochemistry, Krakow, Poland,2Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom

“Identification of metabolic enzymes essential for proliferation and survival of breast cancer cells by functional studies”

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Franziska Baenke1, Claudio Santos1, Ming Jiang2, Becky Saunders2, Gavin Kelly3, Michael Howell2, Almut Schulze1
1Gene Expression Analysis Laboratory Cancer Research UK, London, United Kingdom,2High-Throughput Screening Laboratory Cancer Research UK, London, United Kingdom,3Bioinformatics and Biostatistics Service Cancer Research UK, London, United Kingdom

Discovery of Serum Protein Biomarkers for Prostate Cancer Progression by Proteomic Analysis

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Jamal Alruwaili1, Samantha ET Larkin1, Bashar A Zeidan1, Matthew G Taylor1, Chaker N Adra1, Claire L Aukim-Hastie1, Paul A Townsend1
1university of portsmouth, portsmouth, United Kingdom,2University of Southampton, southampron, United Kingdom,3King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Kingdom of Saudi Arabia, Riyadh- Saudi Ararabia, Saudi Arabia,4Harvard Medical School, Boston, United States

p53 gain-of-function mutations: impact on DNA damage repair

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Jonathan Askham1, Jill Callaghan1, Monica Hollstein1
1University of Leeds, Leeds, United Kingdom

A study of pluripotency potential within the human prostate tissue and establishment of a model to understand prostate growth, development and carcinogenesis.

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Deepali Pal1, Stuart Williamson1, Craig Robson1, Rakesh Heer1
1Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom

A role for the endocytic regulators Rab25 and Rab coupling protein (RCP) in K-Ras dependent colorectal cancer cells.

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Claire Rooney1, Simon Barry1
1AstraZeneca, Macclesfield, United Kingdom

“Late effect of radiotherapy in patients with localized prostate cancer: comparison between IMRT and 3D Conformal Radiotherapy”

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Amir Montazeri1, Isabel Syndikus1, Mona Chopra1, Helen Wong1, Helen Mayles1
1Clatterbridge Centre for Oncology NHS Trust, Wirral, United Kingdom

A phosphatase-independent role for pten in cdc42-mediated epithelial polarization and morphogenesis

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Ishaan Jagan1, Ravi Deevi1, Aliya Fatehullah1, Victoria Bingham1, Mahalaxmi Nagaraju1, Frederick Charles Campbell1
1Centre for Cancer Research and Cell Biology, Belfast, United Kingdom

Survival after first course of palliative radiotherapy: An observational cohort study

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Matt Williams1, David Woolf1, Rob Hughes1, Jane Maher1, Jeanette Dickson1
1Mount Vernon Cancer Centre, London, United Kingdom

The diagnostic potential of serum cytokines, chemokines and growth factors (CCGFs) for pancreatic ductal adenocarcinoma.

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Joseph Man Fung Tang1, Victoria Shaw1, Claire Jenkinson1, William Greenhalf1, John Neoptolemos1, Eithne Costello1
1Division of Surgery and Oncology, Royal Liverpool University Hospital, University of Liverpool, L69 3GA, Liverpool, United Kingdom

Systematic review of interventions for squamous cell carcinoma of the hypopharynx

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Shashi Prasad1, James Oyee2, Catrin Smith2, Martin Birchall3, Andy Ness1
1University of Bristol, Bristol, United Kingdom,2University of Liverpool, Liverpool, United Kingdom,3University College London, London, United Kingdom

Cardiovascular sequelae in long term survivors of childhood cancer

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Marlous van Laar1, Rebecca J. Birch1, Adam Glaser3, Chris P. Gale2, David T. Bowen4, Steven E. Oliver5, Richard G. Feltbower1
1Paediatric Epidemiology Group, University of Leeds, Leeds, United Kingdom,2Division of Biostatistics, University of Leeds, Leeds, United Kingdom,3Paediatric Oncology and Haematology, St James’s University Hospital, Leeds, United Kingdom,4Institute of Oncology, St James’s University Hospital, Leeds, United Kingdom,5Northern and Yorkshire Cancer Registry and Information Service, St James's University Hospital, Leeds, United Kingdom

The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression

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Matthew Murray1, Harpreet Saini2, Stijn van Dongen2, Roger Palmer1, Balaji Muralidhar1, Mark Pett1, Matias Piipari3, Claire Thornton4, James Nicholson5, Anton Enright2, Nicholas Coleman1
1MRC Cancer Cell Unit, Cambridge, United Kingdom,2EMBL-EBI, Hinxton, Cambridge, United Kingdom,3Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom,4Department of Pathology, Royal Group of Hospitals Trust, Belfast, United Kingdom,5Department of Paediatric Haematology and Oncology, Addenbrooke's Hospital, Cambridge, United Kingdom

Glycine as a non-invasive biomarker of malignancy in paediatric brain tumours measured using in-vivo short-TE MRS

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Nigel Davies2, Martin Wilson1, Kal Natarajan2, Eleni Orphanidou1, Yu Sun1, Lesley MacPherson3, Marie-Anne Brundler3, Theodoros Arvanitis1, Richard Grundy4, Andrew Peet1
1University of Birmingham, Birmingham, United Kingdom,2University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom,3Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom,4Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom

Transcriptional acivation of calcium binding S100A2 gene by transforming growth factor-? induced MEK/ERK signaling

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Sarwat Naz1, Prathibha Ranganathan1, Paturu Kondaiah1
1Indian Institute Of Science, Bangalore/Karnataka, India

UK oncologists’ experiences with and attitudes towards non-NHS-funded cancer drugs: Results from an on-line survey

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Lesley Fallowfield1, Ivonne Solis-Trapala2, Louise Parlour1, Carolyn Langridge1, Alison Jones3, Jane Barrett4, Valerie Jenkins1
1Brighton & Sussex Medical School, University of Sussex, Brighton, East Sussex, United Kingdom,2University of Lancaster, Lancaster, Lancashire, United Kingdom,3Royal Free & University College London Medical School, London, United Kingdom,4Royal Berkshire & Battle Hospital, Reading, Berkshire, United Kingdom

The primary health and supportive care needs of long-term cancer survivors

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Sian Harrison1, Eila Watson2, Nada Khan1, Alison Ward1, Monica Roche3, David Forman4, Peter Rose1
1Oxford University, Oxford, United Kingdom,2Oxford Brookes University, Oxford, United Kingdom,3Oxford Cancer Intelligence Unit, Oxford, United Kingdom,4Northern and Yorkshire Cancer Registry and Information Service, Leeds, United Kingdom

The accuracy of two palliative prognostic assessment tools in cancer patients in Grampian

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Sally Lawton1, Lisa Macaulay1, David Carroll1, Gordon Linklater1, Dong Pang2
1Roxburghe House, NHS Grampian, Aberdeen, United Kingdom,2Institute of Applied Health Sciences, Aberdeen, United Kingdom

Views on long term follow-up in breast cancer trials: results from a questionnaire sent to UK centres

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Lucy Kilburn1, Jane Banerji1, Judith Bliss1
1The Institute of Cancer Research, Sutton, United Kingdom

The Effect of Choral Singing on Quality of Life and Lung Function in Cancer Survivors and their Carers

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Nichola Gale1, Ian Lewis2, Stephanie Enright1, Robert van Deurson1
1School of Healthcare Studies, cardiff University, Cardiff, United Kingdom,2Tenovus, Cardiff, United Kingdom

Polygenic susceptibility to prostate and breast cancer and implications for personalised screening programmes

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Nora Pashayan1, Stephen Duffy2, Susmita Chowdhury3, Tom Dent3, Paul Pharoah1
1University of Cambridge, Cambridge, United Kingdom,2Queen Mary University of London, London, United Kingdom,3PHG Foundation, Cambridge, United Kingdom

– Searching for new phosphoinositide binding proteins –

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Lilly Sommer1, Aurélia Lewis2, Duncan Smith1, Clive D’Santos3, Nullin Divecha1
1Paterson Institute for Cancer Research, Inositide Laboratory, Manchester, United Kingdom,2PROBE, University of Bergen, Bergen, Norway,3CRUK Cambridge Research Institute, Li-Ka Shing Center, Cambridge, United Kingdom

Targeting the p53 pathway in renal call carcinoma

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Radoslaw Polanski1, Aidan Noon1, Nikolina Vlatkovic1, Carlos Rubbi1, Mark Boyd1
1University of Liverpool, Liverpool, United Kingdom

PIM kinase inhibitors down regulate STAT3tyr705 phosphorylation

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Marisa Chang1, Nisha Kanwar1, Eric Feng1, Allan Siu1, Xiujie Liu2, Dawei Ma2, Jan Jongstra1
1University Health Network, Toronto, Ontario, Canada,2Shanghai Institute of Organic Chemistry, Shanghai, China

Outcomes of Glioblastoma treated with Radiotherapy with concurrent and adjuvant Temozolomide (RCAT) in routine practice

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Sarah Hargreaves1, Matt Williams1, David Woolf1, Vasiliki Michalarea1, Zi Wei Liu1, Elena Wilson1
1Royal Free Hospital, London, United Kingdom

Metastasis Associated 1 (MTA1) aids the AKT pathway by regulating PTEN

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Shimul Salot1, Rajiv Gude1
1Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, India

Correlation of CD44+/CD24-/low cells with clinicopathological parameters and patients’ outcome in breast carcinoma

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Zahra Madjd1, Mohammad E. Akbari2, Amir Hassan Zarnani3, Ensieh Farahani4
1Dep Pathology & Oncopathology Research Centre, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of,2Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of,3Nanotechnology Research Center, Avicenna Research Institute, Tehran, Iran, Islamic Republic of,4Oncopathology Research Centre,Iran university of medical Sciences, Tehran, Iran, Islamic Republic of

Association of ALDH1 as a marker of cancer stem cell with prognostic factors of breast cancers

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Zahra Madjd1, Babak Ramezani2
1Dep Pathology & Oncopathology Research Centre, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of,2Dep Pathology, Iran University of Medical Sciences,, Tehran, Iran, Islamic Republic of

Proteomic and transcriptomal identification of the mechanisms and consequences of p53 gain of function mutation in laryngeal squamous cell carcinoma

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Anna Behrendt1, Terence Jones1, Carlos Rubbi1, Nikolina Vlatkovic1, Rosalind Jenkins1, Kevin Park1, Bryony Lloyd1, David Ross Sibson1, Mark Boyd1
1University of Liverpool, Liverpool, Merseyside, United Kingdom

A scale-space tracing algorithm for analysis of tumour blood vessel morphology from transmitted light optical images

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Constantino Reyes-Aldasoro1, Meit Björndahl1, Jamila Ibrahim1, Simon Akerman1, Gillian Tozer1
1The University of Sheffield, Sheffield, South Yorshire, United Kingdom

Colorectal polyp cancers in the NHS Bowel Cancer Screening Programme

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Thomas Lee1, Claire Nickerson2, Richard McNally3, Matthew Rutter1
1University Hospital of North Tees, Stockton on Tees, United Kingdom,2NHS Cancer Screening, Sheffield, United Kingdom,3Newcastle University, Newcastle upon Tyne, United Kingdom

A validation study of genes and polymorphisms associated with radiation toxicity: preliminary results of the RAPPER study

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Gillian Barnett1, Catharine West3, Caroline Baynes1, Craig Luccarini1, Don Conroy1, Charlotte Coles2, Rebecca Elliott1, Neil Burnet2, Paul Pharoah1, Alison Dunning1
1Strangeways Research Laboratory, Cambridge, United Kingdom,2Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom,3University of Manchester, Christie Hospital, Manchester, United Kingdom

Preclinical evaluation of novel therapeutic agent AT7519 (CDK inhibitor) for use in the treatment of pancreatic cancer

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Amy Thomas1, Elisabeth Shaw2, Paula Ghaneh1, Carol Walker2, William Greenhalf1, Eithne Costello-Goldring1, Khaled Dajani1, Matthew Squires3, David Ross Sibson2, John P Neoptolemos1
1NIHR Pancreas Biomedical Research Unit, Liverpool, United Kingdom,2University of Liverpool, Liverpool, United Kingdom,3Astex Therapeutics, Cambridge, United Kingdom

Preclinical evaluation of novel therapeutic agent AT13387 (HSP90 inhibitor) for use in pancreatic cancer treatment

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Elisabeth Shaw1, Amy Thomas2, Paula Ghaneh2, Carol Walker1, William Greenhalf2, Michael Davies1, Eithne Costello-Goldring2, Fiona Gibbs1, Kathy Joyce1, Khaled Dajani2, Matthew Squires3, John P Neoptolemos2, David Ross Sibson1
1Univeristy of Liverpool, Liverpool, United Kingdom,2NIHR Pancreatic Biomedical research unit, Liverpool, United Kingdom,3Astex Therapeutics, Cambridge, United Kingdom

Informed consent in surgical oncology: do patients know what they are signing up for?

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Angus McNair1, Jenna Powell2, Sophie Whelan-Johnson2, Natalie Blencowe1, Dan Titcomb2, Richard Huxtable1, Jane Blazeby1
1University of Bristol, Bristol, United Kingdom,2University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom

Prognostic significance of BRCA1 expression in breast carcinoma and its association with cancer stem cell markers

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Zahra Madjd1, Adel Karimi Kivi2
1Dep Pathology and Oncopathology Research Centre, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of,2Dep Pathology, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of

“The Sprouty-related EVH1 Domain-Containing (SPRED) Family of Proteins and Prostate Cancer”

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James Sewell1, Tania Murphy1, Ajay Joseph1, Satoshi Hori1, Craig Robson2, Vincent J Gnanapragasam1
1University of cambridge, Cambridge, United Kingdom,2Northern Institute for Cancer Research, Newcastle upon Tyne, United Kingdom

The NQO1 C609T polymorphism is associated with poorer response to AC adjuvant therapy in the treatment of breast cancer

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David Jamieson1, Nicola Cresti1, Johanne Bray1, Julieann Sludden1, Melanie Griffin1, Eve Famie1, Mark Verrill2, Alan Boddy1
1Northern Institute for Cancer Research, Newcastle upon Tyne, United Kingdom,2Northern Centre for Cancer Care, Newcastle upon Tyne, United Kingdom

Baseline circulating tumour cell (CTC) counts enhance the performance of the Royal Marsden Hospital (RMH) prognostic score to optimise patient selection for Phase 1 clinical trials

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Dionysis Papadatos-Pastos1, Richard Baird1, David Olmos1, Shahneen Sandhu1, Christophe Massard3, Juliet Dukes2, Lorna Pope2, Philippa Grainger2, Timothy Yap1, Johann De-Bono1
1Royal Marsden Hospital, London, United Kingdom,2Institute of Cancer Research, London, United Kingdom,3Institut Gustave Roussy, Villejuif, France

Angiopoietin-2 stimulates TIE2-expressing monocytes to be potent immunosuppressor cells.

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Seth Coffelt1, Abigail Welford1, Yung-Yi Chen1, Munitta Muthana1, Claire Lewis1
1University of Sheffield, Sheffield, United Kingdom

Macrophage infiltration is associated with poor outcome in breast cancer patients and a reduced treatment response to Letrozole and Zoledronate.

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Alex Lee1, Rebecca Lamb1, Hannah Gregson1, Angela Cramer1, July Morris1, Lorna Renshaw1, Matthew Winter1, Robert E Coleman1, Michael J Dixon1, Nigel J Bundred1, Göran Landberg1
1Breakthrough Breast Cancer Research Unit, University of Manchester, Paterson Institute for Cancer Research, Manchester, United Kingdom

Discovery of New Pathways and Mechanisms of Notch Signalling in Angiogenesis

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Esther Bridges1, Anassuya Ramachandran1, Jie Zuo1, Tessa Peterkin1, Martin Taylor2, Harukazu Suzuki3, Philip Pinheiro1, Ji-Liang Li1, Roger Patient1, Adrian Harris1
1Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom,2Human Genetics Unit, University of Edinburgh, Edinburgh, United Kingdom,3RIKEN Omics Science Center, Yokohama Institute, Yokohama, Japan

Serum Biomarkers for the Early Detection of Pancreatic Cancer

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Claire Jenkinson1, Victoria Elliott1, Sarah Tonack1, Victoria Shaw1, Joseph Tang1, Stephane Camuzeaux2, Usha Menon2, Aleksandra Gentry-Maharaj2, John Sinclair2, Stephen Pereira3, William Greenhalf1, John Neoptolemos1, John F Timms2, Eithne Costello1
1Liverpool CR-UK Centre, Liverpool, United Kingdom,2Institute for Women's Health, UCL, London, United Kingdom,3Institute of Hepatology, UCL, London, United Kingdom

Chemo- and radio-sensitisation of hepatocellular carcinoma by the DNA-dependent protein kinase inhibitor NU7441

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Joanne Munck1, Liam Cornell1, Febrina Budhisetiawan1, David Newell1, Julia Bardos2, Helen Reeves1, Nicola Curtin1
1Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom,2KuDOS Pharmaceuticals Ltd, Cambridge, United Kingdom

Targeting Notch in Pancreatic Cancer

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Natalie Cook1, Kris Frese1, Mike Jacobetz1, Meredith Caldwell-Jacobetz1, Tashinga Bapiro1, Aimee Michael2, Christopher Winter2, Duncan Jodrell1, David Tuveson1
1Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom,2Merck Research Laboratories, Boston, United States

FUS/TLS is a novel mediator of androgen-dependent cell cycle progression and prostate cancer growth.

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Greg Brooke1, Rachel Culley1, Alwyn Dart1, Bradley Spencer-Dene1, Marjorie Walker1, Charlotte Bevan1
1Imperial College London, London, United Kingdom

Epidemiology and patterns of care amongst primary central nervous system tumours diagnosed in 16-25 yr olds, between 1990-2009 in Yorkshire, UK.

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Brian Nicholson1, Sue Picton3, Sanjay Dixit5, Gerry O'Reilley4, Carmel Loughrey2, Dan Stark2, Richard Feltbower1
1Leeds Univeristy centre for Epidemiology and Biostatistics, Leeds, West Yorkshire, United Kingdom,2St James University Hospital Institute for Oncology, Leeds, West Yorkshire, United Kingdom,3St James University Hospital Paediatric Oncology Unit, Leeds, West Yorkshire, United Kingdom,4Hull Royal Hospital Department of Neurosurgery, Hull, East Yorkshire, United Kingdom,5Castle Hill Hospital Oncology Centre, Hull, East Yorkshire, United Kingdom

General practice recruitment into a large scale pragmatic randomised trial of PSA testing: Comparison Arm for ProtecT (CAP).

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Emma Turner1, Chris Metcalfe1, Jenny Donovan1, Sian Noble1, Liz Down1, Athene Lane1, David Neal2, Freddie Hamdy3, Richard Martin1
1University of Bristol, Bristol, United Kingdom,2University of Cambridge, Cambridge, United Kingdom,3University of Oxford, Oxford, United Kingdom

A GENOME-WIDE ASSOCIATION STUDY OF BREAST CANCER PROGNOSIS

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Qi Guo1, Jean Abraham1, Carlos Caldas1, Christina Curtis1, Helena Earl1, Jonathan Tyrer1, Montse Garcia-Closas2, Nazneen Rahman2, Diana Eccles3, Gareth Evans4, Douglas Easton1, Per Hall5, Peter Kraft6, Paul Pharoah1
1University of Cambridge, Department of Oncology, Cambridge, United Kingdom,2Institute of Cancer Research, Sutton, United Kingdom,3Princess Anne Hospital, Southampton, United Kingdom,4St Mary's Hospital, Manchester, United Kingdom,5Karolinska Institutet, Stockholm, Sweden,6Harvard School of Public Health, Boston, United States