809 abstracts found.



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Introduction: Stratified medicine

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Alan Ashworth1
1The Institute of Cancer Research, London, UK


Imaging tumour metabolism using hyperpolarised 13C magnetic resonance spectroscopy

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Kevin Brindle1
1University of Cambridge, Cambridge, UK


Introduction: The diagnostic and therapeutic potential of the tumour microenvironment

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Thorsten Hagemann1
1Barts Cancer Institute, London, UK


Human cancer epigenetics

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Manel Esteller1
IDIBELLBellvitge Biomedical Research Institute


Modelling the role of the tumour microenvironment in therapeutic response

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Michael Hemann1
1MIT, Cambridge, MA, USA


The immune suppressive tumour stromal cell expressing Fibroblast Activation Protein (FAP) belongs to a cellular lineage mediating essential physiological functions

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Douglas Fearon1
1Cancer Research UK Cambridge Research Institute, Cambridge, UK


Post-translational chemokine modification prevents intratumoral infiltration of antigen-specific T cells

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Vincenzo Bronte1
1Verona University, Verona, Italy


HDAC inhibitors: From bench to clinic, and back again

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Nicholas La Thangue1
1University of Oxford, Oxford, UK


Epigenetic plasticity and the basis of human cancer

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Andrew Feinberg1
1Johns Hopkins University, Baltimore, MD, USA


Introduction: Predictive mouse models of human cancer

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David Tuveson1
1Cancer Research UK, Cambridge, UK


Can genetic risk profiling in colorectal cancer guide prevention and screening?

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Malcolm Dunlop1
1University of Edinburgh, Edinburgh, UK


Harnessing transposons for cancer gene discovery

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Neal Copeland1
1Institute of Molecular and Cell Biology, Singapore, Singapore


Introduction: EMT in cancer, development and tissue maintenance

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Nick Hastie1
1MRC Human Genetics Unit, Edinburgh, UK


Studying therapy response and resistance in mouse models of human breast cancer

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Jos Jonkers1
1Netherlands Cancer Institute, Amsterdam, The Netherlands


MicroRNAs, EMT and cancer stem cells

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Thomas Brabletz1
1University of Freiburg, Freiburg, Germany


Modelling and targeting differentiation-state heterogeneity in cancer

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Piyush Gupta1
1Whitehead Institute for Biomedical Research, Cambridge, MA, USA


Intravital imaging of metastasis

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Erik Sahai1
1Cancer Research UK London Research Institute, London, UK


Introduction: Metabolism and cancer

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Eyal Gottlieb1
1Beatson Institute for Cancer Research, Glasgow, UK


Metabolic alterations to support cancer cell proliferation

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Matthew Vander Heiden1
1Koch Institute at MIT, Cambridge, MA, USA


Predicting selective drug targets in cancer through metabolic networks

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Tomer Shlomi1
1Technion, Haifa, Israel


Introduction: Transformational impact of symptom control for cancer patients

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Peter Selby1
1Cancer Research UK Centre, Leeds, UK


Overview on how symptom control and dealing with toxicity has changed over the last decade and enabled the delivery of more complex and effective treatment

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Martin Gore1
1Royal Marsden Hospital, London, UK


Cancer and bone – minimizing the clinical impact of bone complications

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Robert Coleman1
1Weston Park Hospital, Sheffield, UK


Work and cancer survivors

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Michael Feuerstein1
1Uniformed Services University, Bethesda Maryland, USA


Introduction: Colorectal cancer screening in the United Kingdom: Successes, failures and future developments

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Robert Steele1
1University of Dundee, Dundee, UK


Food, nutrition, physical activity, and cancer prevention: evidence and recommendations

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Martin Wiseman1
1WCRF International, London, UK

SNW1 as a novel regulator of BMP signalling during early embryonic development

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Sabine Reichert1, Mary Y. Wu1, Marie-Christine Ramel1, Caroline S. Hill1
1CR-UK London Research Institute, London, UK


Chemoprevention successes and surprises

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John Baron1
1University of North Carolina, Chapel Hill, NC, USA

Elevated stromal Foxp3+ regulatory T cells combined with low density CD8+ cytotoxic T cells are associated with colorectal metastatic tumour progression

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Helen Angell1, Xiu Huan Yap2, Sunita Mistry2, Marie Cumberbatch2, Neil Gray2, Chris Womack2, Sue Watson3, David Pritchard1, Robert Wilkinson4
1School of Pharmacy, University of Nottingham, Nottingham, UK, 2Molecular Pathology Group, AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, UK, 3School of Medical and Surgical Sciences, University of Nottingham, Nottingham, UK, 4Innovative Medicines Oncology, AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, UK

HDAC6 inhibition down regulates c-FLIP and induces caspase 8-dependent apoptosis in colorectal cancer cells

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Emma Kerr1, Caitriona Holohan1, Kirsty McLaughlin1, Joel Riley1, Patrick Johnston1, Daniel Longley1
1Centre for Cancer Research and Cell Biology, Belfast, UK

Small molecule inhibitors of metabolic flux as potential antitumour agents

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Jonathan Williams1,2, Adrian Harris2, Angela Russell1,3, Carole Bataille1, Stephen Davies1, Gu Liu1, Andrew Lomas2,3, Anassuya Ramachandran2
1Chemistry Research Laboratory, University of Oxford, Oxford, UK, 2Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK, 3Department of Pharmacology, University of Oxford, Oxford, UK

Novel mouse models for specific targeting and visualisation of lymphatic vasculature in vivo

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Lukas Stanczuk1, Florence Tatin1, Taija Makinen1
1CR-UK London Research Institute, London, UK

Wnt/ β-catenin regulation of embryonic NANOG (NANOG1) defines colorectal cancer stem cells and modulated by c-Jun/TCF4 transcriptional activity

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Elsayed Ibrahim1, Abdolrahman Shams Nateri1
1University of Nottingham, Nottingham, UK


Introduction: Epigenetics and cancer

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Peter D. Adams1
1Institute of Cancer Sciences, Glasgow, UK


Tailoring treatment in lung cancer

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Jean-Charles Soria1
1Institut Gustave Roussy, Villejuif, France


Parallel clinical trials in cells, mice and patients to define the genetic bases of response and resistance to targeted therapies in CRCs

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Alberto Bardelli1
TOUniversity of Torino-Medical School, Candiolo


The challenges for the implementation of molecular diagnostics in the clinical setting

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David Gonzalez de Castro1
1The Institute of Cancer Research, London, UK

Notch signalling mediates myofibroblast differentiation of carcinoma-associated fibroblasts

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Ahmet Acar1,2, Göran Landberg2, Akira Orimo1
1CR-UK Stromal-Tumour Interaction Group, Paterson Institute for Cancer Research, Manchester, UK, 2Breakthrough Breast Cancer Research Unit, School of Cancer, Enabling Sciences and Technology, University of Manchester, Manchester Academic Health Science Centre, Paterson Institute for Cancer Researc, Manchester, UK

TLR2 and TLR4 expression in inflammatory gastric lesion before and after  Helicobacter pylori eradication therapy

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Aline Cristina Targa Cadamuro1, Patrícia Biselli2, Rodrigo Castro2, Fausto Nasser3, Patrícia Fucuta3, Edla Bedin Polsinelli3, Kenji Miyasaki3, André Volpatto3,4, Ricardo Acayaba4, Eny Maria Goloni Bertollo2, Ana Elizabete Silva1
1UNESP - São Paulo State University, São José do Rio Preto, Brazil, 2Famerp - School of Medicine, São José do Rio Preto, Brazil, 3Base Hospital, São José do Rio Preto, Brazil, 4João Paulo II Hospital, São José do Rio Preto, Brazil

K-ras 146, N-ras 12/13, and N-ras 61 mutations in Quasar1 stage II/III colorectal cancers occur in 6% of cases.  A small but important group?

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Katie Southward1, Morag Taylor1, Kelly Handley2, Laura Magill2, Phil Chambers1, Claire Beaumont1, Susan Richman1, Matt Seymour3, David Kerr4, Richard Gray2, Phil Quirke1
1Leeds Institute of Molecular Medicine, Leeds, UK, 2Birmingham Clinical Trials Unit, Birmingham, UK, 3Cancer Research UK Clinical Centre, Leeds, UK, 4Department of Clinical Pharmacology, Oxford, UK

Imaging the development of functional tumour vasculature in vivo in preclinical models

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Gemma Marston1, Nicola Ingram1, Mark Hull1, Alex Markham1, Pam Jones1, P. Louise Coletta1
1University of Leeds, Leeds, UK

Defining a spatially restricted aPKC/ERK phosphoproteome

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Nick Peel1, Carine Rosse1, Katrina Boeckeler1, Peter Parker1
1CR-UK London Research Institute, London, UK

Lgr5 stem cells in self-renewal and cancer

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Hans Clevers1
1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences & University Medical Centre Utrecht, Utrecht, The Netherlands

Analysing paired array-comparative genomic hybridisation and gene expression microarray data: A novel method to infer gene relationships

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Xin Yi Goh1,2, Richard Newton3, Lorenz Wernisch3, Rebecca Fitzgerald1
1MRC Cancer Cell Unit, Cambridge, UK, 2University of Cambridge, Cambridge, UK, 3MRC Biostatistics Unit, Cambridge, UK

Chemoprevention: Why do we keep getting it wrong?

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John Potter1
1University of Washington, Seattle, USA, 2Massey University, Wellington, New Zealand

Modelling drug sensitivity and resistance in tumour-derived cell lines

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Jeff Settleman1
1Genentech, South San Francisco, USA

Improving cancer survival in England:  Driving for the best

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Sir Mike Richards1
1National Clinical Director for Cancer and End of Life Care, England, UK

Genome stability: From worms to human disease

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Simon Boulton1
1Cancer Research UK, London Research Institute, South Mimms, UK

TOR signalling and the control of cell growth

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Michael N. Hall1
1Biozentrum, University of Basel, Basel, Switzerland

Cancer survivorship: Surveying the landscape of cancer survivorship research

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Eva Grunfeld1
1University of Toronto, Toronto, Canada