809 abstracts found.



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Hypoxia–induced  cytotoxic drug resistance in osteosarcoma is independent of HIF-1alpha

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Jenny Adamski1,2, Caroline Dive1,2, Guy Makin1,2
1Paterson Institute, Manchester, UK, 2University of Manchester, Manchester, UK, 3Manchester Cancer Research Centre, Manchester, UK, 4Manchester Academic Health Sciences Centre, Manchester, UK

PulMiCC (Pulmonary metastasectomy in colorectal cancer) trial

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Tom Treasure1, Belinda Lees2
1University College London, London, UK, 2Royal Brompton and Harefield NHS Foundation Trust, London, UK

Pten and epithelial morphology

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Fredrik Berglund1, Ranjala Weerasinghe1, Joseph Lim1, Lindsay Davidson1, Nick Leslie1
1University of Dundee, Dundee, UK

Cell Player assays for cancer research: fully quantitatitive live-cell kinetic monitoring

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Tim Dale1, Derek Trezise1, Tim O'Callaghan1
1Essen Bioscience Ltd, Welwyn Garden City, UK

Disruption of notch signalling stabilizes melanoma vasculogenic mimicry

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Amalia Vartanian1, Eugenia Stepanova1, Galina Gritsina1, Anatoly Baryshnikov1, Mikhail Lichinitser1
1Russian Cancer Research Center, Moscow, Russia

A role for clathrin in vaccinia-induced actin polymerisation

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Ashley Humphries1, Mark Dodding1, Lucy Collinson1, Michael Way1
1CR-UK London Research Institute, London, UK

A role for Def1 truncation in DNA damage-induced RNA polymerase II degradation

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Marcus Wilson1, Michelle Harreman1, Michael Taschner1, Jesper Svejstrup1
1CR-UK London Research Institute, Clare Hall Laboratories, South Mimms, UK

Angiopoietin-2 deficiency enhanced tumour growth and neo-angiogenesis via reinforcement of neutrophil recruitment mediated by G-CSF/CXCL1 during the liver metastasis

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Jae Hong Im1, Thomas Tapmeier1, Lukxmi Balathasan1, Sabira Yameen1, Sally Hill1, Sean Smart1, Olivier Noterdaeme2, Matthew Kelly2, Michael Brady2, Weili Fu3, Karoline Kruse4, Eric Bernhard1, Hellmut Augustin4, Ruth Muschel1
1Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK, 2University of Oxford, Oxford, UK, 3Biology Oncology CEDD, GlaxoSmithKline, Philadelphia, USA, CBTMJoint Research Division Vascular Biology, Medical Faculty Mannheim

HDAC inhibitors induce c-FLIP down-regulation and caspase 8 dependent apoptosis in non-small cell lung carcinoma

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Joel Riley1, Izabela Stasik1, Dean Fennell1, Patrick Johnston1, Daniel Longley1
1Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, UK

Combination therapy: effects on cells of the tumour microenvironment

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Thea Rogers1, Diane Lefley1, Alyson Evans1, Hannah Brown1, Natasha Wind1, Penelope Ottewell1, Ingunn Holen1
1University of Sheffield, Sheffield, UK

Characterisation of invasive and metastatic subpopulations of colon cancer using a preclinical model

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Philip Dunne1, Sandra Van Schaeybroeck1, Murugan Kalimutho1, Daniel Longley1, Patrick Johnston1
1Queen's University Belfast, Northern Ireland, UK

Foxp3+ regulatory T cells suppress CD56+ natural killer cell-mediated tumour killing in a transforming growth factor-β dependent manner

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Helen Angell1, Sue Watson2, Robert Wilkinson3, David Pritchard1
1School of Pharmacy, University of Nottingham, Nottingham, UK, 2School of Medical and Surgical Sciences, University of Nottingham, Nottingham, UK, 3Innovative Medicines Oncology, AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, UK

Creating site-specific DNA damage to analyse replicative lesion bypass in S. cerevisiae

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Elizabeth Colby1, Helle Ulrich1
1CR-UK London Research Institute, Clare Hall Labs, London, UK

Measurement of cell death in vivo using magnetic resonance with TE-averaged PRESS and DTI

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Lawrence Kenning1, Martin Lowry1, Lindsay Turnbull1
1University of Hull, East Yorkshire, UK

Adherent non-small cell lung cancer cell lines are resistant to gefitinib induced cell killing

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Sivan Bokobza1, Anderson Ryan1
1University of Oxford, Oxford, UK

The influence of matriptase-2 on prostate cancer in vitro: a possible role for β-catenin

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Siobhan Webb1, Andrew Sanders1, Malcolm Mason1, Wen Jiang1
1Cardiff University, Cardiff, UK

Spatial regulation of Ras signalling networks

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Veronica Aran1, Ian Prior1
1University of Liverpool, Liverpool, UK

Trastuzumab decorated cellular uptake studies: effect of different sugar based polymeric redispersible spray dried nanoparticles encapsulating COX-2 inhibitor an antiangiogenic drug in MCF 7

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Aftab Alam1, Zeenat Iqbal1, Sushama Talegaonkar1, Farhan J Ahmad1, Dinesh G Goswami2, Amulya K Panda1
1Jamia Hamdard, New delhi, India, 2National Institute of Immunology, New Delhi, India

Does cytoglobin afford protection from intracellular oxidative stress in normal and cancerous oesophageal cells ?

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Fiona McRonald1,2, Janet Risk2, Nikolas Hodges1
1University of Birmingham, Birmingham, UK, 2University of Liverpool, Liverpool, UK

Aldehyde dehydrogenase activity as a marker for cancer stem cells in uveal melanoma

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Rachel Doherty1, Leslie Hoh2, Ian Rennie2, Karen Sisley2, Neil Cross1
1Sheffield Hallam University, Sheffield, UK, 2University of Sheffield, Sheffield, UK

The autophagic tumour stroma of cancer metabolism – a new model for cancer

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Stephanos Pavlides1,2, Richard Pestell2, Anthony Howell1, Federica Sotgia1,2, Michael P. Lisanti1,2
1University of Manchester, Manchester, UK, 2Thomas Jefferson University, Philadelphia, USA

Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7

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Triparna Sen1, Amitava Chatterjee1
1Chittaranjan National Cancer Institute, Kolkata, West bengal, India

Recruitment of monocytes/macrophages by tumour cell clot formation is essential for metastatic cell survival

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Ana Maria Gil-Bernabe1, Spela Ferjancic1, Monika Tlalka1, Lei Zhao1, Thomas Tapmeier1, Danny Allen1, Karla Watson1, Sally Hill1, Ruth Muschel1
1University of Oxford, Oxford, UK

Evaluation of psychological and physiological mechanisms of chemotherapy related fatigue

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Nicholas Stuart1, Sally Wilson1, Samuele Marcora1
1University of Bangor, Bangor, UK

Regulation of growth factor receptor signalling and trafficking by Ack1

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Sylwia Krawczyk1, Giulio Auciello1, Debbie Cunningham1, Joshua Rappoport1, John Heath1
1University of Birmingham, Birmingham, UK

FLIP as a critical target for SAHA in mesothelioma

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Izabela Stasik1, Jane Hurwitz1, Sara Busacca1, Steven Gray2, Ken O'Byrne2, Dean Fennell1, Daniel Longley1
1Queen’s University, Belfast, UK, 2St. James’s Hospital, Dublin, Ireland

Using clinical attendance patterns to determine likely survivorship journey (colorectal cancer, multiple myeloma, Hodgkin’s disease) in England

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J Wells1, A Woolmore1, T Welchman1, KL Edwards2, K Harris3, H Nai3, J Flynn4, J Ritchie-Campbell4, D Forman5
1Monitor Group, Europe, UK, 2University of Nottingham, School of Clinical Sciences, Nottingham, UK, 3University of Leeds, Centre of Epidemiology and Biostatistics, Leeds, UK, 4Macmillan Cancer Support, London, UK, IARCInternational Agency for Research on Cancer

Identification of epigenetic mechanisms for downregulation of Tensin3 in human renal cell carcinoma

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Jessica Carter1, Börje Ljungberg2, Sassan Hafizi1
1University of Portsmouth, Portsmouth, UK, 2Umeå University, Umeå, Sweden

Knock-down of receptor-like protein tyrosine phosphatase kappa (PTPRK) inhibits in vitro cell growth and invasion in prostate cancer cells.

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Ping-Hui Sun1, Lin Ye1, Malcolm D. Mason1, Wen G. Jiang1
1Cardiff University, Cardiff, UK

Using travel time analysis to inform the decision making process regarding the provision of late effects care clinics for childhood cancer survivors in peninsula

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Matthew Iles1, Mike Stevens2, Paul Beynon2, Veronique Poirier1, Julia Verne1
1South West Public Health Observatory, Bristol, UK, 2University Hospitals Bristol NHS Foundation Trust, Bristol, UK

Efficacy of a cognitive behavioural intervention to treat menopausal symptoms following breast cancer treatment (MENOS 1): a randomised trial

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Eleanor Mann1, Melanie Smith1, Jennifer Hellier1, Hisham Hamed2, Myra Hunter1
1King's College London, London, UK, 2Guy’s and St Thomas’ Foundation Trust, London, UK

The challenge of using non-participant observation to research care at the end of life: a pilot study to involve professionals and lay people in key aspects of research design

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Maureen Gambles1, Elizabeth Perkins2, Clare Thetford2, Kate Nolan1, Alan Haycox3, John Ellershaw1
1Marie Curie Palliative Care Institute Liverpool, University of Liverpool, Liverpool, UK, 2Health and Community Care Unit, University of Liverpool, Liverpool, UK, 3Management School, University of Liverpool, Liverpool, UK

Supportive and palliative care needs of patients with thoracic cancer at diagnosis

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Asmah Hussain1,2, Matthew Maddocks2, Rachel Bentley2, Cheryl Percival2, Helena Alvey2, Ruth Pashley2, Andrew Wilcock1,2
1University of Nottingham, Nottingham, UK, 2Nottingham University Hospitals NHS Trust, Nottingham, UK

Late onset bowel dysfunction after pelvic radiotherapy: a national survey of clinical oncologists

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Caroline Henson1, Jervoise Andreyev2, Paul Symonds3, David Peel3, Ric Swindell1, Susan Davidson1
1Christie NHS Foundation Trust, Manchester, UK, 2Royal Marsden NHS Foundation Trust, London, UK, 3Leicester Royal Infirmary, Leicester, UK

Inter-observer variation in target volume definition for the SCOPE 1 pre-trial test case

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Sarah Gwynne1, Emiliano Spezi1, John Staffurth1, Patricia Diez2, Lisette Nixon3, Ruby Al-Mokhtar3, Lucy Wills1, Gareth Griffiths3, Elizabeth Miles2, Tom Crosby1
1Velindre Cancer Centre, Cardiff, UK, 2Mount Vernon Cancer Centre, London, UK, 3Wales Cancer Trials Unit, Cardiff, UK

Patient-reported outcomes after treatment of intraocular melanoma

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Laura Hope-Stone1,2, Peter Salmon1, Bertil Damato2,1
1University of Liverpool, Liverpool, UK, 2The Royal Liverpool & Broadgreen University Hospitals NHS Trust, Liverpool, UK

The British Thoracic Oncology Group national lung cancer follow-up survey results

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Paul Beckett1, Lynn Calman1, Liz Darlison1, Clive Mulatero1, Mick Peake1, Denis Talbot1
1British Thoracic Oncology Group, UK, UK

Quantifying nutritional support needs of patients with thoracic cancer: findings of a dedicated rehabilitation service

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Cheryl Percival1, Asmah Hussain1, Sonja Zadora-Chrzastowska1, Matthew Maddocks1,2, Gillian White1, Andrew Wilcock1,2
1Nottingham University Hospitals NHS Trust, Nottingham, UK, 2University of Nottingham, Nottingham, UK

Fertility preservation in women undergoing treatment for breast cancer in the UK: a questionnaire study

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Judy King1, Nicola Roche3, Melanie Davies2, Jacinta Abraham4, Alison Jones1,2
1Royal Free Hampstead NHS Trust, London, UK, 2University College London Hospitals NHS Foundation Trust, London, UK, 3The Royal Marsden NHS Foundation Trust, London, UK, 4Velindre Cancer Centre, Wales, UK

Exploring the journeys for older people with cancer in South-West Wales

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Amina Mehta1, Deborah Fitzsimmons1, Jaynie Rance1, Colin Johnson2, Aled Jones1
1University, Swansea, UK, 2University, Southampton, UK

Factors influencing exercise capacity in people with thoracic cancer

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Matthew Maddocks1,2, Ruth England2, Cathann Manderson2, Andrew Wilcock1,2
1University of Nottingham, Nottingham, UK, 2Nottingham University Hospitals NHS Trust, Nottingham, UK

Effects of high intensity resistance training in patients with advanced prostate cancer treated with androgen deprivation therapy: a randomised assessment.

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Nicholas Stuart1, Sally Wilson1, Sam Oliver1, Nichola Callow1, Corine Thorne1, Samuele Marcora1
1University of Bangor, Wales, UK

Lifestyle habits during and after prostatic radiotherapy influences the risk of late toxicity

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Robert Thomas1,2, Mea Holm1,4, Madeleine Williams1, Pat Bellamy2, Emily Bowman3, Jervoise Andreyev5, Jane Maher3
1The Primrose Oncology Research Unit, Bedford, UK, 2Cranfield Univeristy, Bedford, UK, 3Macmillan Cancer Support, London, UK, 4Oxford University, Oxford, UK, 5The Royal Marsden Hospital, London, UK

Update on phase 1/2 evaluation of chemotherapy plus residual tumour excision for Testis conservation

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Tim Oliver1, Jonathan Shamash1, Vinod Nargund1
1Barts and The London School of Medicine, London, UK

Late onset bowel dysfunction after pelvic radiotherapy: A national survey of gastroenterologists

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Caroline Henson1, Susan Davidson1, Paul Symonds2, Ric Swindell1, Jervoise Andreyev3
1The Christie NHS Foundation Trust, Manchester, UK, 2Leicester Royal Infirmary, Leicester, UK, 3Royal Marsden NHS Foundation Trust, London, UK

Doubling recruitment to clinical trials at the Royal United Hospital, Bath: focusing on our strengths

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Hannah Taylor1, Louise Medley1, Christine Cox1, Samantha Curtis1, Rachel Bolitho1, Tania Allen1, Samantha Febrey1, Joanne Avis1
1Royal United Hospital, Bath, UK

Consumer involvement in cancer research: a network example  

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Mubashir Arain1, Sarah Pyne2, Nigel Thornton2, Susan Palmer1, Ricky Sharma1
1Thames Valley Cancer Research Network, Oxford, UK, 2Thames Valley Cancer Network, Oxford, UK

Increased anxiety and depression in British South Asian cancer patients

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Paul Symonds1,2, Karen Lord2, Kausher Ibrahim2, Sawan Kumar2, Nicky Rudd2, Alex Mitchell1,2
1University of Leicester, Leicester, UK, 2University Hospitals of Leicester NHS Trust, Leicester, UK

Lifestyle issues for colorectal cancer survivors – the challenge of meaningful communications

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Annie Anderson1, Joanne Coyle1, Robert Steele1
1University of Dundee, Dundee, UK

The informational and psychological needs of patients in the early phases of the cancer trajectory: A qualitative study of breast, prostate and lung cancer patients

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Paul Baker1, Helen Beesley2, Robert Dinwoodie2, Janice Ablett2, Peter Salmon1
1University of Liverpool, Liverpool, UK, 2Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK