776 abstracts found.



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Expression of Interleukin-10 in ovarian carcinoma: A Diagnostic Tool and its significance in diagnosis & therapy

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Arti Verma1, Rohit Kumar Srivastava1, Dinesh Tripathi1, PushpLata Sankhwar2, Sunita Tiwari1
1King George's Medical University, Lucknow, India, 2King George's Medical University, Lucknow, India

Genome-wide profiling identifies novel determinants of PARP 1/2 inhibitor sensitivity

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Ilirjana Bajrami1, Jessica Frankum1, James Campbell1, Asha Kigozi1, Farah Rehman1, Rachael Natrajan1, Rachel Brough1, Rowan Miller1, Christopher Lord1, Alan Ashworth1
1The Institute of Cancer Research, London, UK

The non-inhibitory serpin maspin influences epithelial-to-mesenchymal transition in breast cancer

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Louise Brown1, Sarah Jenkinson1, Rosemary Bass1
1Northumbria University, Newcastle upon Tyne, UK

The characterisation and functional assessment of epithelial ovarian cancer cells derived from ascitic fluid using ImageStreamX

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Madeleine Moat1, Rachel O’Donnell1, Barry Dent1, Laura Ogle1, Nicola Curtin1, David Jamieson1, Richard Edmondson1,2
1Newcastle University, Newcastle upon Tyne, UK, 2Northern Gynaecological Oncology Centre, Gateshead, UK

Comprehensive analysis of molecular features associated with survival in clear cell renal cell carcinoma

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Sakshi Gulati1, Marco Gerlinger1,2, Pierre Martinez1, Nicolai Juul-Birbak3, Tejal Joshi3, Zoltan Szallasi3,4, Charles Swanton1,5, Paul A Bates1
1Cancer Research UK London Research Institute, London, UK, 2Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, London, UK, 3Technical University of Denmark, Lyngby, Denmark, 4Harvard Medical School, Boston, USA, 5University College London Cancer Institute, London, UK

Using next generation sequencing to profile microRNAs in FFPE head and neck squamous cell carcinoma samples: A pilot study

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Neeraj Sethi1, Lucy Stead1, Caroline Conway1, Catherine Daly1, Philip Egan1, Henry Wood1, Kenneth MacLennan1, Pamela Rabbitts1
1Leeds Institute of Molecular Medicine, Leeds, UK

MGMT promoter hypermethylation is present in low grade glioma and GBM in the absence of IDH mutations

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Harry Haynes1, Charlene Crosby2, Hannah Williams1, Kirsten Hopkins3, Maggie Williams2, Kathreena Kurian1
1Frenchay Hospital, Bristol, UK, 2Southmead Hospital, Bristol, UK, 3Bristol Royal Infirmary, Bristol, UK

Role and regulation of p53/ mouse double minute 2 homolog (MDM2) complex in Merlin-deficient tumours

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C Oliver Hanemann1, Sylwia Ammoun1, Lu Zhou1, Marei Caroline Schmid1, Magdalena Barczyk1
1Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK

Moving Mdm2 inhibition into the clinic

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Patricia Roxburgh1,2, Carol Hopkins1, Robina Ullah1, Jeff Evans1,2, Karen Vousden2
1University of Glasgow, Glasgow, UK, 2Beatson Institute for Cancer Research, Glasgow, UK

T11TS impedes glioma angiogenesis via inhibition of Ang-1/Tie-2 signaling and induction of brain endothelial cell apoptosis

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Debanjan Bhattacharya1, Swapna Chaudhuri1
1Department of Laboratory Medicine, School of Tropical Medicine, Kolkata, India

A functional approach to determine the implications of PDGFR/KIT amplification in glioblastoma by clonal analysis

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Roman Reinartz1, Anja Wieland1, Daniel Trageser1, Mihaela Keller1, Matthias Simon2, Hans-Ulrich Schildhaus3, Oliver Brüstle1, Martin Glas1, Björn Scheffler1
1Institute of Reconstructive Neurobiology, Bonn, Germany, 2Department of Neurosurgery, Bonn, Germany, 3Institute of Pathology, Cologne, Germany

A novel synthetic lethality application targeting ATM and DNA-PKcs in BRCA1 deficient cancer cells

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Nada Albarakati1, Tarek Abdel Fatah2, Paul Moseley2, Stephen Chan2, Claire Seedhouse4, Ian Ellis3, Srinivasan Madhusudan1,2
1Laboratory of Molecular Oncology, Academic Unit of Oncology, School of Molecular Medical Sciences, University of Nottingham, Nottingham University Hospitals, Nottingham, UK, 2Department of Oncology, Nottingham University Hospitals,, Nottingham, UK, 3Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham University Hospitals, Nottingham, UK, 4Academic Haematology, School of Molecular Medical Sciences, University of Nottingham, Nottingham University Hospitals, Nottingham, UK

GAS5 regulates apoptosis and responses to chemotherapeutic drugs in breast cancer cell lines

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Mark Pickard1, Will Hudson2, Eric Ortlund2, Gwyn Williams1
1Keele University, Keele, UK, 2Emory University School of Medicine, Atlanta, USA

Application of a cytochrome P450 CYP2D6 humanised mouse model to the study of tamoxifen metabolism, drug-drug interaction and efficacy

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Kenneth MacLeod1, Lesley McLaughlin1, Nico Scheer2, Anja Rode2, Colin Henderson1, Roland Wolf1
1University of Dundee, Dundee, UK, 2TaconicArtemis, Koeln, Germany

A relationship between hyperpolarised 13c pyruvate metabolism and tumour volume in a magnetic resonance spectroscopy study of chronic dichloroacetate treatment in a rat model

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Tooba Alizadeh1, Steven Reynolds1, Stephen Metcalf1, Becky Bibby1, Adriana Bucur1, Samira Kazan1, Martyn Paley1, Gillian M Tozer1
1University of Sheffield, Sheffield, UK

VEGFR-1 and VEGFR-2 mediated changes in tumour vascularisation and the tumour microenvironment in single VEGF isoform expressing tumours

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Sarah Jane Lunt1, Diane Lefley1, Rachel Daniel1, Matthew Fisher1, Chryso Kanthou1, Gillian Tozer1
1University of Sheffield, Sheffield, UK

Modulation of pharmacodynamic biomarkers in a Phase I clinical trial of AUY922, a Heat Shock Protein 90 inhibitor

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Karen Swales1, Udai Banerji1, Michelle D Garrett1
1The Institute of Cancer Research, Sutton, UK

Mechanism of regulation of Protein Kinase C iota (PKCι) by Phosphoinositide-dependent kinase 1 (PDK1)

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Julien de Naurois1,2, Peter Parker2, Banafshé Larijani1
1Cell Biophysics Lab, Cancer Research UK, London Research Institute, London, UK, 2Protein Phosphorylation Lab, Cancer Research UK, London Research Institute, London, UK

Measurement of the acute response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

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Steven Reynolds1, Joanne Bluff1, Tooba Alizadeh1, Samira Kazan1, Stephen Metcalf1, Emily Wholey1, Leigh Williams1, Adriana Bucur1, Becky Bibby1, Martyn Paley1, Gillian M Tozer1
1University of Sheffield, Sheffield, UK

Defining the role of cytochrome P450 CYP3A4 in imatinib disposition in a humanised mouse model

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Zoe Riches1, Lesley McLaughlin1, Anja Rode2, Nico Scheer2, Colin Henderson1, Roland Wolf1
1University of Dundee, Dundee, UK, 2TaconicArtemis, Koeln, Germany

Characterisation of the CHD1 chromatin remodeller in embryonic stem cells

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Michael Lim1, Andreas Ehrensberger1, Matthieu Gérard2, Jesper Svejstrup1
1Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, UK, 2CEA Saclay, iBiTecS, Gif-Sur-Yvette, France

FLIP and caspase-8 expression in NSCLC: Clinically relevant targets for HDAC inhibitors

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Joel Riley1, Izabela Stasik1, Patrick Johnston1, Daniel Longley1
1Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, UK

EZH2 expression in posterior fossa childhood ependymomas

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Ben Ede1, Zsombor Melegh2, Karim Malik3, Richard Grundy4, Kathreena Kurian1
1Brain Tumour Research Group, Bristol, UK, 2Southmead Hospital, Bristol, UK, 3Bristol University, Bristol, UK, 4Nottingham University, Nottingham, UK

Pharmacodynamic modulation of the PI3-Kinase/Akt Pathway in surrogate tissues from patients on the Phase I study of the oral class I PI3K inhibitor CH5132799

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Shaun Decordova1, Karen Swales1, James Spicer2, Sarah Blagden3, Chris Twelves4, Udai Banerji1, Michelle D Garrett1
1The Institute of Cancer Research, Sutton, UK, 2Guy's Hospital, London, UK, 3Imperial College London, London, UK, 4St. James University Hospital, Leeds, UK

The predominant modes of FLIP, FADD and Caspase 8’s interactions at the DISC

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Joanna Majkut1, Miriam Sgobba1, Caitriona Holohan1, David Haigh1, Daniel Longley1
1Centre for Cancer Research and Cell Biology, Queens University, Belfast, UK

Elucidating the role of WAC in autophagy

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Justin Joachim1,2, Nicole McKnight3, Harold Jefferies1, Sharon Tooze1
1London Research Institute, Cancer Research UK, London, UK, 2University College London, London, UK, 3Mount Sinai School of Medicine, New York, USA

Phytoestrogen interactions with oestrogen receptor and breast cancer progression 

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Carlos Lopez-Balcazar1, Miriam Dwek1
1University of Westminster, London, UK

Apical membrane formation during angiogenesis in vivo

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Véronique Gebala1, Li-Kun Phng2, Holger Gerhardt1,2
1Vascular Biology Laboratory, Cancer Research UK London Research Institute, London, UK, 2Vascular Patterning Laboratory, Vesalius Research Center, VIB, KU Leuven, Leuven, Belgium

How does Vaccinia virus recruit Clathrin machinery?

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Xenia Snetkov1, Ashley Humphries1, Michael Way1
1Cancer Research UK London Research Institute, London, UK

Endothelial cell shape regulation: From the cell to the plexus

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Filipa Neto1, Claudio Franco1, Holger Gerhardt1
1Cancer Research UK, London, UK

The use of apoptotic markers to predict rectal cancer response to neo-adjuvant therapy

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Rikesh Patel1,2, Victoria Green3, Rishi Srivastava1,2, Ramsah Cheah2, Iain Andrew Hunter1, John Greenman3
1Castle Hill Hospital, Cottingham, UK, 2Hull York Medical School, Hull, UK, 3University of Hull, Hull, UK

Investigating the quantitative model for cell cycle progression in fission yeast

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Matthew Swaffer1, Paul Nurse1
1Cancer Research UK London Research Institute, London, UK

ATR-Chk1 and ATM-Chk2 signalling axis is linked to adverse clinicopathological outcomes in sporadic human epithelial ovarian cancers

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Arvind Arora1, Tarek MA Abdel-Fatah1, Paul Moseley1, Kerstie Johnson1, Nada Albarakata2, Christina Perry1,2, Christopher Kent1, Khalid Hameed1, Stephen Chan1, Srinivasan Madhusudan1,2
1Department of Oncology, Nottingham University Hospitals NHS Trust, Nottingham, UK, 2Laboratory of Molecular Oncology, Academic Unit of Oncology, School of Molecular Medical Sciences, University of Nottingham, Nottingham University Hospitals, Nottingham, UK

Matrix metalloproteinase-8 (collagenase-2) induces expression of interleukins-6 and -8 in breast cancer cells

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Julie Decock1, Sally Thirkettle1, Hugh Arnold1, Caroline J Pennington1, Diane Jaworski2, Dylan R Edwards1
1School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK, 2Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, USA

Senstivity study for plasma DNA sequencing using the Ion Torrent next generation sequencing

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Nathalie Zahra1, Karen Page1, David Guttery1, Ricky Trigg1, Lindsay Primrose1, Jacqui Shaw1
1University of Leicester, Leicester, UK

The effect of cancer associated fibroblasts on invasion and proliferation of melanoma cells, in a 3D environment

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Njainday Jobe1, Barbora Dvoánková1, Daniel Rösel1, Karel Smetana Jr1, Jan Brabek1
1Charles University in Prague, Prague, Czech Republic

Proteasomal inhibition sensitises cervical cancer cells to Mitomycin C induced bystander killing

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Shivendra Vikram Singh1, Amrendra Kumar Ajay1, Manoj Kumar Bhat1
1National Center for Cell Science, Pune, India

The Hippo pathway polarises the actin cytoskeleton during collective migration of Drosophila border cells

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Ichha Khanal1, Eliana Lucas1, Pedro Gaspar1, Georgina Fletcher1, Cedric Polesello1, Nicolas Tapon1, Barry Thompson1
1Cancer Research UK London Research Institute, London, UK

Kidins220/ARMS: a potential regulator between neuronal survival and death

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Nathalie Schmieg1, Claire Thomas1, Arisa Yabe1, Fabrizia Cesca2, Giampietro Schiavo1
1Cancer Research UK London Research Institute, London, UK, 2Instituto Italiano de Technologia, Genova, Italy

Investigation of Gifinitib(Iressa) effect on the epidermal growth factor receptor (EGFR) of HN5 and T47D cell lines using Dielectrophoresis (DEP)

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Sina Mahabadi1, Michael Hughes1, Fatima Labeed1, Helen Coley1
1University of Surrey, Guildford, UK

MiR-224 negatively regulates SMAD4 and may represent a novel method of bypassing SMAD4 tumour suppression in colorectal carcinogenesis

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Karen Pickard1, Marc Bullock1, Richard Mitter2, Chris Paraskeva3, Gareth Thomas1, John Primrose1,4, Graham Packham1, Alex Mirnezami1,4
1University of Southampton, Southampton, UK, 2Cancer Research UK, London, UK, 3University of Bristol, Bristol, UK, 4Southampton University Hospital NHS Trust, Southampton, UK

The long and the short of it: Cell size control in fission yeast

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Elizabeth Wood1, Paul Nurse1
1Cancer Research UK London Research Institute, London, UK

Bedside-to-bench: Clinical response to CDK4 inhibition uncovers a novel MDM2- dependent, p53-independent senescence pathway

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Marta Kovatcheva1, D David Liu1, Aimee Crago1, Mark Dickson1, Gary Schwartz1, Sam Singer1, Andrew Koff1
1Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, USA

Unexpected findings in mouse models to deplete dendritic cells

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Janneke van Blijswijk1, Barbara Schraml1, Neil Rogers1, Caetano Reis e Sousa1
1Cancer Research UK, London Research Institute, London, UK

An all-Ireland population-based study of past and current physical and psychological side-effects following prostate cancer treatments

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Heather Kinnear1, Frances Drummond2, Linda Sharp2, Anna Gavin1, Lesley Anderson1
1Queen's University Belfast, Belfast, UK, 2National Cancer Registry Ireland, Cork, Ireland

Cancer-resistant species as a new paradigm for cancer research

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Joao Pedro de Magalhaes1
1University of Liverpool, Liverpool, UK

Time since diagnosis and health related quality of life in prostate cancer survivors in Ireland

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Frances Drummond2, Heather Kinnear1, Katie O'Brien2, Anna Gavin1, Linda Sharp2
1Queen's University Belfast, Belfast, UK, 2National Cancer Registry Ireland, Cork, Ireland

Correlation between CK positive CTCs and cfDNA levels of in metastatic breast cancer patients

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Stephanie Marchese2, Allison Hills2, Laura Woodley2, Karen Page1, David Guttery1, Justin Stebbing2, Charles Coombes2, Jacqui Shaw1
1University of Leicester, Leicester, UK, 2Imperial College London, London, UK

A review of association between carcinogenesis and metabolic syndrome in relation to sirtuins

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Constantinos Savva1, Evangelos Briasoulis2
1Norfolk and Norwich University Hospital, Norwich, UK, 2University of Ioannina, Ioannina, Greece

Mechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironment

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Wen Wen Xu1, Bin Li1, Sai Wah Tsao1, Kwok Wah Chan1, Annie Lai Man Cheung1
1University of Hong Kong, Hong Kong, Hong Kong