896 abstracts found.



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Introduction: Circulating biomarkers: where have we got to and what’s on the horizon?

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Caroline Dive1
1Cancer Research UK, Manchester, UK

Molecular profiling of single circulating tumour cells with diagnostic intention

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Christoph Klein1,2
1University of Regensburg, Regensburg, Germany,2Fraunhofer Project Group, ITEM-Regensburg, Germany

Circulating cell-free DNA as a strong multimarker diagnostic, theranostic and prognostic tool for metastatic colorectal cancer patients management care

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Alain R Thierry1
1French Institute of Health and Medical Research (INSERM), Montpellier, France

Using next generation sequencing to characterise in detail the biological mechanisms that underpin genomic instability in ETV6-RUNX1 ALL and identify recurrent drivers associated with leukemic transformation

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Elli Papaemmanuil1
1Wellcome Trust Sanger Institute, Cambridge, UK

Development of precision medicine trials for Philadelphia chromosome-like acute lymphoblastic leukaemia

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Stephen Hunger1,2
1University of Colorado School of Medicine, Aurora, USA,2Children's Hospital Colorado, Aurora, USA

Introduction: Drug resistance modelling – patients, organoids and mice

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David Adams1
1Wellcome Trust Sanger Institute, Cambridge, UK

Olaparib penetrates glioblastoma at therapeutic levels: results of stage 1 of the OPARATIC trial; a phase I study of olaparib in combination with temozolomide in patients with relapsed glioblastoma

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Anthony Chalmers1, Alan Jackson2, Helen Swaisland3, William Stewart4, Sarah Halford5, Rhoda Molife6, Darren Hargrave7, Alex McCormick3
1University of Glasgow, Glasgow, UK,2University of Manchester, Manchester, UK,3AstraZeneca Ltd, Macclesfield, UK,4NHS Greater Glasgow & Clyde, Glasgow, UK,5Cancer Research UK Drug Development Office, London, UK,6Royal Marsden Hospital, London, UK,7Great Ormond Street Hospital, London, UK

Cancer cell models as a therapeutic biomarker discovery platform

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Mathew Garnett1
1Wellcome Trust Sanger Institute, Cambridge, UK

Unravelling therapy resistance in mouse models of human breast cancer

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Jos Jonkers1
1Netherlands Cancer Institute, Amsterdam, The Netherlands

Introduction: Human papilloma virus (HPV)-positive head and neck cancer

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Kevin Harrington1
1The Institute of Cancer Research, London, UK

Human papillomavirus: the biology of carcinogenesis

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Ned Powell1
1Cardiff University, Cardiff, UK

Clinical Trials Of MVA-EBNA1/LMP2, A Therapeutic Cancer Vaccine Designed To Treat Epstein-Barr Virus (EBV) Positive NasopharyngealCarcinoma (NPC)

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Neil Steven1,6, Kevin Harrington2, Lip Lee3, Edwin Hui9, Hui Jia1, David Price4, Kristin Ladell4, James Turner1, Manjit Tanday1, Claudia Roberts6,1, Ceri Edwards5, Lesley McGuigan5, Andrew Hartley6, Stephen Wilson7, Benjamin Johnson8, Anthony Chan9, Alan Rickinson1, Graham Taylor1
1School of Cancer Sciences, The University of Birmingham, Birmingham, England, UK,2Department of Cancer Biology, Institute of Cancer Research, London, England, UK,3Department of Clinical Oncology, The The Christie NHS Foundation Trust, Manchester, England, UK,4Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Wales, UK,5Drug Development Office, Cancer Research UK, London, England, UK,6University Hospital Birmingham NHS Foundation Trust, Birmingham, England, UK,7Health Protection Agency, West Midlands Public Health Laboratory, Birmingham, England, UK,8Section of Virology, Imperial College, London, England, UK,9The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China

What differences should there be in the way we treat HPV +ve and HPV -ve squamous cell cancer of the head and neck?

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Kevin Harrington1
1The Institute of Cancer Research, London, UK

The immune response in HPV-positive oropharyngeal cancer

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Gareth Thomas1
1University of Southampton, Southampton, UK

Introduction:Lung cancer and mesothelioma

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Marianne Nicolson1
1Royal Aberdeen Infirmary, Aberdeen, UK

Genomics of lung cancer

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Ramaswamy Govindan1
1Washington University School of Medicine, St Louis, USA

Investigating small cell lung cancer molecular status and heterogeneity utilising circulating tumour cells

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Louise Carter1, Dominic G Rothwell1, Yaoyong Li2, Deborah J Burt1, Jenny Antonello1, Matthew G Krebs1,3, Jakub Chudziak1, Lynsey Priest1, Crispin Miller2, Gillian Ellison5, Fiona Blackhall3,4, Caroline Dive1, Ged Brady1
1Clinical and Experimental Pharmacology, Cancer Research UK Manchester Institute, Manchester, UK,2RNA Biology Group/ Computational Biology, Cancer Research UK Manchester Institute, Manchester, UK,3Christie NHS Foundation Trust, Manchester, UK,4Institute of Cancer Sciences, University of Manchester, Manchester, UK,55AstraZeneca Pharmaceuticals, Cheshire, UK

Liquid biopsies: genotyping circulating tumour cells

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David Planchard1
1Gustave Roussy, Paris, France

Introduction: New methods for tumour functional imaging

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Kevin Brindle1
1University of Cambridge, Cambridge, UK

Developing novel radiotracers for positron emission tomography: probing different cancer phenotypes and therapy response in living subjects

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Eric O Aboagye1
1Imperial College London, London, UK

Integration of cancer genome sequencing and dynamic functional imaging to assess the metabolic effects of metformin in breast cancer: a neoadjuvant window of opportunity clinical study

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Simon Lord1,2, Neel Patel3, Dan Liu3, John Fenwick3, Fergus Gleeson3, Syed Haider1,2, Francesca Buffa1, Adrian Harris1,2
1Department of Oncology, University of Oxford, Oxford, UK,2Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK,3Oxford Cancer Imaging Centre, University of Oxford, Oxford, UK

Tumour detection, treatment planning and response assessment using functional magnetic resonance

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Martin O Leach1
1The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, UK, London, UK

Introduction: Toxicities of anti-cancer therapies

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Sam Ahmedzai1
1University of Sheffield, Sheffield, UK

Mucositis and personalised cancer medicine: supportive care makes excellent cancer care possible

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Dorothy Keefe1,2
1University of Adelaide, Adelaide, South Australia, Australia,2SA Cancer Service, Adelaide, South Australia, Australia

Radiogenomics Consortium meta-analysis of four genome wide association studies of late toxicity after radiotherapy for prostate cancer

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Catharine West1, Gill Barnett2, Sarah Kerns3, Laura Fachal4, Neil Burnet2, Alison Dunning5, Antonio Gómez-Caamaño6, Harry Ostrer7, Paul Pharoah5, Barry Rosenstein3, Ana Vega4, Matt Parliament8
1University of Manchester, Manchester, UK,2Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK,3Icahn School of Medicine at Mount Sinai, New York, USA,4Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain,5University of Cambridge, Cambridge, UK,6Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain,7Albert Einstein College of Medicine, New York, USA,8Cross Cancer Institute, Alberta, Canada

A new era in understanding and managing chronic gastrointestinal (GI) consequences of cancer treatment

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Jervoise Andreyev1
1The Royal Marsden NHS Foundation Trust, London, UK

Supportive care in cancer patients: a unifying concept

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Jean A Klastersky1
1Institut Jules Bordet - ULB, Brussels, Belgium

Introduction: What makes a target attractive for cancer drug discovery

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Donald Ogilvie1
1ancer Research UK Manchester Institute, Manchester, UK

Identifying and prosecuting the right targets in oncology

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Graeme Smith1
1AstraZeneca, Alderly Park, UK

A modern interpretation of the 5 Rs of radiobiology and their impact on clinical practice

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Kevin Harrington1
1The Institute of Cancer Research, London, UK

Combining radiotherapy with DNA repair inhibitors in the lab and the clinic

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Anthony Chalmers1
1University of Glasgow, Glasgow, UK

Genetic screens exploring tumour radiosensitivity 

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Geoff Higgins1
1Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Oxford, UK

Introduction: DNA repair in cancer biology and treatment

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Chris Lord1
1The Institute of Cancer Research, London, UK

Break-induced replication mediates repair of collapsed DNA replication forks and tandem duplications in cancer cells

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Thanos Halazonetis1
1University of Geneva, Geneva, Switzerland

PET imaging of DNA damage using 89Zr-labelled anti-γH2AX-TAT immunoconjugates

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James Knight1, Caitriona Topping1, Veerle Kersemans1, Nadia Falzone2, Nicola Sibson1, Bart Cornelissen1
1University of Oxford, Oxford, UK,2Institute for Cancer Research, Sutton, Surrey, UK

APOBEC3B mutagenesis in cancer: basic mechanisms and clinical implications

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Reuben Harris1
1University of Minnesota, Minneapolis, UK

DNA repair defects, PARP inhibitors and metastatic prostate cancer

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Johann de Bono1
1The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK

A patient viewpoint – integrate oncology and palliative care

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Roger Wilson1,2
1NCRI Consumer Liaison Group, London, UK,2Sarcoma UK, London, UK

A ‘battle’ or a ‘journey’? A large-scale study of metaphors for cancer

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Elena Semino1, Zsofia Demjen2, Jane Demmen1, Andrew Hardie1, Veronika Koller1, Sheila Payne1, Paul Rayson1
1Lancaster University, Lancaster, UK,2Open University, Milton Keynes, UK

Integrating palliative care into oncology – improving the palliative care of cancer patients in the care pathway

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Tiina Saarto1
1Helsinki University and Helsinki University Central Hospital, Helsinki, Finland

A phase II mixed-methods study on early integration of palliative care in advanced respiratory and gastrointestinal cancer patients

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Massimo Costantini1
1Hospital of Santa Maria Nuova, Florence, Italy

Introduction: Melanoma

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Pippa Corrie1
1Addenbrooke's Hospital, Cambridge, UK

In vivo RNAi screening for novel therapeutic cancer targets

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Daniel Peeper1
1Netherlands Cancer Institute, Amsterdam, The Netherlands

G12DNRAS and kinase-dead BRAF cooperate to drive naevogenesis and melanomagenesis

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Malin Pedersen1, Amaya Viros2, Martin Cook2, Richard Marais2
1The Institute of Cancer Research, London, UK,2The Cancer Research UK Manchester Institute, Manchester, UK

The aging microenviroment promotes metastasis and therapy resistance

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Ashani T Weeraratna1
1Melanoma Research Center, The Wistar Institute, Philadelphia, USA

Tumour heterogeneity and co-operative behaviour in melanoma 

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Claudia Wellbrock1
1Manchester Cancer Research Centre, University of Manchester, Manchester, UK

Introduction: Molecular pathology – the genomic basis of cancer

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Manuel Salto-Tellez1
1Queen’s University Belfast, Belfast, UK

Epidermal growth factor receptor copy number gain (EGFR CNG) and response to gefitinib in oesophageal cancer (OC): Results of a biomarker analysis of a phase III  trial of gefitinib versus placebo (TRANS-COG).

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Russell Petty1,14, Asa Dahle-Smith1,14, Zofia Miedzybrodzka1,14, Susan Dutton2, Graeme Murray1,14, David Stevenson14, Doreen Massie14, Aileen Osbourne14, Caroline Clark14, Was Mansoor5, Joyce Thompson6, Mark Harrison7, Anirban Chatterjee8, Stephen Falk4, Sean Elyan9, Angel Garcia-Alonso10, David Fyfe12, Ian Chau11, Corran Roberts2, David Ferry13,2
1University of Aberdeen, Aberdeen, UK,2University of Oxford, Oxford, UK,3New Cross Hospital, Wolverhampton, UK,4University Hospitals Bristol NHS Foundation Trust, Bristol, UK,5Christie Hospital, Manchester, UK,6Birmingham Heartlands Hospital, Brimingham, UK,7Mount Vernon Cancer Centre, London, UK,8Royal Shrewsbury Hospital, Shrewsbury, UK,9Cheltenham General Hospital, Cheltenham, UK,10North Wales Cancer Centre, Rhyl, UK,11Royal Marsden Hospital, London, UK,12University Hospitals of Morrecombe Bay, Barrow in Furness, UK,13Lilly UK, Windlesham, UK,14NHS Grampian, Aberdeen, UK

Molecular pathology: the genomic basis of cancer

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Reinhard Buettner1
CIOCologne University Hospital and Center for Integrated Oncology

Genomics, integromics and the role of molecular pathology

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Manuel Salto-Tellez1
1Queen’s University Belfast and Belfast Health and Social Care Trust, Belfast, UK