793 abstracts found.



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Assessment of a set of simple selection criteria to identify patients who may benefit from Breath hold left-sided breast radiotherapy on basis of mean heart dose

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Nikhil Tanna1,Ruth McClaughlan1,Stephanie Karis1,Camarie Welgemoed1,Susan Cleator1

1Imperial College Healthcare NHS Trust, London, UK


Tumour Metabolism in Squamous Cell Carcinoma of the Head and Neck (SCCHN): An In-Vitro Study of the Consequences of TP53 Mutation and Therapeutic Implications

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Mark Wilkie1,Andrew Lau1,Nikolina Vlatkovic1,Terry Jones1,Mark Boyd1

1Department of Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, UK


Single cell analysis of gene expression in Schizosaccharomyces pombe

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James Patterson1,Paul Nurse1

1The Francis Crick Institute, London, UK


Patient factors associated with non-completion of colonic testing after a positive Faecal occult blood test

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Andrew Plumb1,Alex Ghanouni2,Yoryos Lyratzopolous2,Sandra Rainbow3,Steve Halligan1,Christian von Wagner2

1UCLH, London, UK,2UCL, London, UK,3London Bowel Cancer Screening Hub, London, UK


Variations in GPs’ Decisions to Investigate Suspected Lung Cancer: A Factorial Experiment Using Multimedia Vignettes

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Jessica Sheringham1,Rachel Sequeira1,Jonathan Myles2,Willie Hamilton3,Joe McDonnell4,Judith Offman2,Stephen Duffy2,Rosalind Raine0

1UCL, London, UK,2QMUL, London, UK,3University of Exeter, Exeter, UK,4London Borough of Waltham Forest, London, UK


Progression risk assessments of individual non-invasive gastric neoplasms by genomic copy-number profile

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Diem Vo1,Takahisa Nakayama1,Hiroto Yamamoto1,Ken-ichi Mukaisho1,Takanori Hattori1,Kenzo Hotta1,Tomoyuki Otani1,Hiroyuki Sugihara1

1Shiga University of Medical Science, Otsu, Japan


SF3B1 and EIF1AX mutations in Uveal Melanoma

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Serdar Yavuzyigitoglu1,2,Anna Koopmans1,2,Kyra Smit1,2,Jolanda Vaarwater1,2,Dion Paridaens4,Robert Verdijk3,Emine Kilic1,Annelies de Klein2

1Erasmus MC, Department of Clinical Genetics, Rotterdam, The Netherlands,2Erasmus MC, Department of Ophthalmology, Rotterdam, The Netherlands,3Erasmus MC, Department of Pathology, Rotterdam, The Netherlands,4The Rotterdam Eye Hospital, Rotterdam, The Netherlands


The Oncology Complex Care Meeting: enhancing in-patient care through interdisciplinary communication

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Caroline Dobeson1,Rachel Nirsimloo1,Naomi Moodley1,Elizabeth MacDonald2

1Edinburgh Cancer Centre, Western General Hospital, Edinburgh, UK,2Department of Medicine for the Elderly, Western General Hospital, Edinburgh, UK


Gluthathione peroxidase-1 (GPX-1) gene Pro198Leu polymorphism: importance in breast cancer

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Negar Zaheddoust1,Zivar Salehi1,Mohammad javad Mehdipour Moghaddam1,Hamid Saedi Saedi2

1Department of Biology, Faculty of sciences, University of Guilan, Rasht, Iran,2Guilan University of Medical Sciences, Rasht, Iran


Streamlining a chemotherapy triage helpline within the Acute Oncology Service (AOS)

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May Teoh1,Agnieszka Kehinde1,Samantha Russell1,Julia Whittle1,Amanda Houston1,Stephanie Wynter1,Simon Page1,Victoria Mumford1

1Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK


New Possible Targetable Genes For Future Treatment of MLL Leukemias

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Senol Dogan1,Amina Kozaric1,Fatih Ozturk1

1International Burch University, Sarajevo, Bosnia and Herzegovina


Genetic variations of SEPP1 in Iranian patients with breast cancer

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Samaneh Mohammaddoust1,Zivar Salehi1,Hamid Saeidi Saedi2

1Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Guilan, Iran,2Guilan University of Medical Sciences, Rasht, Guilan, Iran


Knowledge of modifiable risk factors for breast cancer in women attending NHS breast symptomatic clinics and breast screening mammography

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Ellen Copson1,Ellena Sheldon2,Mark McCann3,Lyn Brierley-Jones4,Julia Sinclair2

1Cancer Sciences Academic Unit, University of Southampton, Southampton, UK,2University Department of Psychiatry, University of Southampton, Southampton, UK,3MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK,4Department of Pharmacy, Health and Well-being University of Sunderland, Sunderland, UK


Does the poor overall survival of patients with cancer of unknown primary reflect tumour biology or late emergency presentation?

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Caroline Fong1,Amy Summers1,Antonia Barbieri1,Elizabeth Summers1,Dave Riley1,Richard Jones1,Amanda Bissett1,Roshan Agarwal1

1Northampton General Hospital, Northampton, UK


A Phase I dose-escalating and safety study of AZD8931 in combination with Oxaliplatin and Capecitabine chemotherapy in patients with Oesophago-gastric adenocarcinoma

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Anne Thomas1,Martin Eatock2,Nick Coupe3,Naomi McGregor4,Sharon Love4,Pradeep Virdee4,Linda Collins4,Karina Meachin5,Cathy McDowell6,Mark Middleton3

1University of Leicester, Leicester, UK,2Northern Ireland Cancer Centre, Belfast, UK,3University of Oxford, Oxford, UK,4Oncology Clinical Trials Office, University of Oxford, Oxford, UK,5AstraZeneca, Cambridge, UK,6Cancer Research UK, London, UK


Astrocyte activation by brain metastases alter brain vascular function

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Sébastien Serres1,Manuel Sarmiento-Soto1,James R Larkin1,James A Meakin2,Alexandr Khrapitchev1,Claire Bristow1,Vasiliki Economopoulos1,Carole Escartin3,Gilles Bonvento3,Nicola R Sibson1

1CRUK & MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK,2FMRIB Centre, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK,3MIRcen, UMR9199 CEA CNRS University of Paris Sud,, Fontenay-aux-Roses, France


Temporal clustering of neuroblastic tumours in children and young people from northern England

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Colin Muirhead1,Deborah Tweddle1,Nermine Basta1,Richard McNally1

1Newcastle University, Newcastle, England, UK


Detection of brain tumours using translational molecularly targeted magnetic resonance imaging

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Sébastien Serres1,Matthew Kirkman1,Nick de Pennington1,Claire Bristow1,Nicola R Sibson1

1Cancer Research UK & Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford,, Oxford, UK


Loss of Guanine Nucleotide Exchange Factors (GEFs) Vav2, Vav3 and Tiam1 results in prolonged survival in a Rac-dependent manner following APC loss, in a genetically engineered mouse model of Colorectal Cancer.

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Karen Pickering1,Kevin Myant2,Owen Sansom1

1Beatson Institute, Glasgow, UK,2Edinburgh Cancer Research Centre, Edinburgh, UK


Modern pelvic chemoradiotherapy techniques continue to affect the small bowel

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Katherine White1,Caroline Henson2,Sorrel Burden3,Simon Lal2,Susan Davidson1,John McLaughlin3

1The Christie NHS Foundation Trust, Manchester, UK,2Salford Royal NHS Foundation Trust, Manchester, UK,3University of Manchester, Manchester, UK


Does Buparlisib plus thoracic radiotherapy reduce hypoxia in patients with non-small cell lung cancer? The use of F-MISO imaging in a phase I dose-escalation trial

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Daniel R McGowan1,2,Ruth E Macpherson3,Naomi McGregor1,Sharon Love4,Pradeep Virdee4,Fergus V Gleeson1,3,John D Fenwick1,Geoff Higgins1

1Department of Oncology, University of Oxford, Oxford, UK,2Radiation Physics and Protection, Oxford University Hospitals NHS Trust, Oxford, UK,3Department of Radiology, Oxford University Hospitals NHS Trust, Oxford, UK,4Centre for Statistics in Medicine, University of Oxford, Oxford, UK


A landmark programme to understand the needs and experiences of all people affected by blood cancer.

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Lauren Dias1

1Leukaemia & Lymphoma Research, London, UK


Identification of neutral tumour evolution across cancer types

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Marc Williams1,2,Benjamin Werner3,Chris P. Barnes2,Trevor A. Graham1,Andrea Sottoriva3

1Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK,2Computation Systems and Synthetic Biology Laboratory, Cell and Developmental Biology, University College London, London, UK,3Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK


Using technology to enhance communication, discussion and dissemination of palliative care research: the development of the MyPal palliative care podcast

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Amara Nwosu1

1Marie Curie Palliative Care Institute Liverpool (MCPCIL), University of Liverpool, Liverpool, UK


Increased in CCL2 levels is a negative prognostic marker in colorectal liver metastasis patients treated with eicosapentaenoic acid

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Milene Volpato1,Andrew Cockbain1,Sarah Perry1,Gemma Marston1,Nicola Ingram1,Jake Mann1,Heather Burghel1,Erica Wilson2,Juliette Randerson-Moor2,Alasdair Droop2,Louise Coletta1,Mark Hull1

1University of Leeds, LIBACS, Leeds, UK,2University of Leeds, LICAP, Leeds, UK


EURAMOS-1: an international collaboration for osteosarcoma

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Jeremy S Whelan1,Matthew R Sydes10,Stefan S Bielack2,Sigbjørn Smeland4,Neyssa Marina3,Gordana Jovic10,Trude Butterfass-Bahloul5,Gabriele Calaminus6,Mikael Eriksson7,Hans Gelderblom8,Richard G Gordlick9,Pancras Hogendoorn8,Jane Hook10,Leo Kager11,Mark D Krailo12,Thomas Khüne13,R Lor Randall14,Kirsten Sundby Hall4,Lisa A Teot15,Mark Bernstein16

1University College Hospital, London, UK,2Olgahospital, Klinikum Stuttgart, Stuttgart, Germany,3Stanford University School of Medicine, Palo Alto, CA, USA,4Oslo University Hospital, The Norwegian Radium Hospital, Scandinavian Sarcoma Group, Oslo, Norway,5Center for Clinical Trials, University of Münster,, Münster, Germany,6University Hospital of Münster, Münster, Germany,7Skane University Hospital and Lund University, Lund, Sweden,8Leiden University Medical Center, Leiden, The Netherlands,9The Children’s Hospital, Bronx, NY, USA,10MRC Clinical Trials Unit at UCL, London, UK,11St Anna Children’s Hospital, Vienna, Austria,12Childrens Oncology Group, Arcadia, CA, USA,13University Children’s Hospital Basel, Basel, Switzerland,14Huntsman Cancer Inst, Salt Lake City, UT, USA,15Children’s Hospital Boston, Boston, MA, USA,16IWK Health Centre, Halifax, NS, Canada


A collaborative hit-finding approach to identify novel inhibitors of mutant isocitrate dehydrogenase 1.

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Jonathan Ahmet1,Nicola Hamilton1,Kelly Ayton1,Mark Cockerill1,Eddie McKenzie2,Emma Fairweather1,Paul Harper3,Stuart Jones1,Colin Levy1,Martin Packer4,Darren Plant3,Ian Sinclair3,Iain Simpson4,Peter Simpson4,Helen Small1,Graeme Thomson1,Michael Tonge3,Ian Waddell1,Mark Wigglesworth3,Donald Ogilvie1

1Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK,2Manchester Institute of Biotechnology, Manchester, UK,3Discovery Sciences, AstraZeneca, Alderley Park, UK,4Oncology iMED, AstraZeneca, Alderley Park, UK


Personalised medicine and pain control: pharmacogenetic profiling for responsiveness to opioids (P-PRO)

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Amara Nwosu1,Stephen Mason1,Munir Pirmohamed2,Richard Fitzgerald3,Anna Gola4,Stein Kaasa5,John Ellershaw1

1Marie Curie Palliative Care Institute Liverpool (MCPCIL), University of Liverpool, Liverpool, UK,2Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK,3Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK,4Faculty of Brain Sciences, University College London, London, UK,5Institute of Cancer Research and Molecular Medicine, Norwegian University of Trondheim, Trondheim, Norway


Hyperglycaemia is associated with intermediate and high grade prostate cancer among Swedish men

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Rhonda Arthur1,Henrik Møller1,Hans Garmo1,Lars Holmberg1,Niklas Hammar2,Göran Walldius2,Ingmar Jungner2,Håkan Malmström2,Mats Lambe3,Mieke Van Hemelrijck1

1King’s College London, Division of Cancer Studies, Cancer Epidemiology Group, London, UK,2Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden


First-in-class inhibitors of the putatively undruggable DNA repair target Poly(ADP-ribose) glycohydrolase (PARG)

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Allan Jordan1,Ben Acton1,Emma Fairweather1,Niall Hamilton1,Nicola Hamilton1,Sarah Holt1,James Hitchin1,Colin Hutton1,Dominic James1,Stuart Jones1,Alison McGonagle1,Helen Small1,Kate Smith1,Alexandra Stowell1,Ian Waddell1,Bohdan Waszkowycz1,Donald Ogilvie1

1CRUK Manchester Institute, Manchester, UK


Pre-treatment lymphocytopaenia is a prognostic biomarker in muscle-invasive and advanced bladder cancer.

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Nuradh Joseph1,Simon Dovedi1,Catherine Thompson1,Jeanette Lyons1,Jason Kennedy1,John Logue1,James Wylie1,Tony Elliott1,Jacqueline Livsey1,Catherine Coyle1,Nooreen Alam1,Anna Tran1,Ananya Choudhury1

1The Christie NHS Foundation Trust, Manchester, UK


Cytochrome P450 3A4 (CYP3A4) -humanised mice for the study of anti-cancer drug pharmacokinetics

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A. Kenneth MacLeod1,Colin Henderson1,Nico Scheer2,C. Roland Wolf1

1University of Dundee, Dundee, UK,2Taconic Biosciences, Cologne, Germany


51Cr-ETDA testing for Carboplatin dosing: What tumour groups is it used for and does it impact the dose given?

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Joanna Connor1,Ilana Raburn1,Helen Wong1,Ernie Marshall1

1Clatterbridge Cancer Centre, Merseyside, UK


Demonstrating an Effective Model of Patient and Public Involvement in Cancer Research

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Ellen Donovan1,2,Sophie Gasson2,David Chuter2,Robert Flavel2,Maggie Wilcox2,Helen-Teresa Edwards2

1Royal Marsden NHS Foundation Trust/Institute of Cancer Research, London, UK,2KSS Local Research Network, Kent, Surrey and Sussex, UK


Correlations of incidence rates of Hodgkin lymphoma subtypes in children and young adults with age, sex and deprivation

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Rachel Reeves1,Peter James1,Nermine Basta1,Jill McKay1,Tevfik Dorak2,Richard McNally1

1Newcastle University, Newcastle, England, UK,2Liverpool Hope University, Liverpool, England, UK


Completion of Chemotherapy and Survival Outcomes for Advanced Oesophago-gastric Adenocarcinoma at the Northern Ireland Cancer Centre

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Laura Feeney1,Michael J Devlin1,Peter Gallagher1,Jirhe David-Okugbeni2,Kyle Crawford1,Rachel Campbell1,Claire Harrison1,Colin Purcell1,Richard C Turkington1,2,Martin Eatock1,2

1Northern Ireland Cancer Centre, Belfast City Hospital, Belfast, UK,2Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, UK


Cytostatic ruthenium(II) polypyridyl anti-cancer compounds

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Martin Gill1,Kate Vallis1,Carl Smythe2,Amitava Das3

1University of Oxford, Oxford, UK,2University of Sheffield, Sheffield, UK,3CSIR-National Chemical Laboratory, Pune, India


Patient-Derived Xenograft Models of Breast Cancer with Human Immune Components

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Rebecca Marlow1,Kristina Ilieva1,Fernanda Kyle1,Erika Francesch1,Patrycja Gazinska1,Panagiotis Karagiannis1,Frank Nestle1,Adrian Hayday1,Sophia Karagiannis1,Andrew Tutt1

1Kings College London, London, UK


Validation of Prognostic Indices in Locally Advanced and Metastatic Oesophago-gastric Cancer

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Michael J Devlin1,Laura Feeney1,Peter Gallagher1,Jirhe David-Okugbeni1,Kyle Crawford1,Rachel Campbell1,Claire Harrison1,Colin Purcell1,Martin Eatock1,2,Richard C Turkington1,2

1Northern Ireland Cancer Centre, Belfast City Hospital, Belfast, UK,2Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, UK


Targeting the mismatch repair pathway in ovarian cancer

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Jacqueline Burgon1,Ashleigh Herriott1,David Jamieson1,Aiste McCormick1,Maddie Moat1,Rachel O’Donnell1,Nicola Curtin1,Yvette Drew1

1Northern Institute of Cancer Research, Newcastle Upon Tyne, UK


The Salt Inducible Kinase 2 (SIK2) links lipid metabolism to survival of ovarian cancer metastasis

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Fabrizio Miranda1,2,Shujuan Liu1,2,Sandra Herrero-Gonzalez1,2,David Mannion1,2,Stefan Knapp3,Ahmed Ahmed1,2

1Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK,22Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Women’s Centre, John Radcliffe Hospital, Oxford, UK,33Nuffield Department of Clinical Medicine, SGC, Old Road Campus Research Building, Oxford, UK


From Expert to Novice: A Mixed Method Study of New Clinical Research Nurses’ Perceptions of Role Transition

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Kuljinder Sandhu1

1Newcastle University, Newcastle, UK,2Calderdale & Huddersfield NHS Foundation Trust, Huddersfield, West Yorkshire, UK


How does the Multi-Disciplinary team impact on recruitment into Clinical Trials?

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Nichola Daker1,2

1Newcastle University, Newcastle, UK,2Calderdale and Huddersfield NHS Foundation Trust, West Yorkshire, UK


HKMTI-1-005 in Combination with Decitabine- A Novel Epigenetic Therapy to Combat Chemoresistance In Ovarian Cancer

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Sarah Kandil1,Ian Green1,Edward Curry2,Nahal Masrour1,Matthew Fuchter2,Robert Brown1

1Department of Surgery & Cancer, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0NN, UK,2b Department of Chemistry, Imperial College London, South Kensington Campus, , London SW7 2AZ,, UK


YoDA BRCA: A web-based decision aid to support decisions about genetic testing at diagnosis of breast cancer in young women

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Claire Foster1,Chloe Grimmett1,Alejandra Recio-Saucedo2,Ramsey Cutress3,Ellen Copson3,Diana Eccles4,Garath Evans5,Sue Gerty6,Anne Armstrong7,Lesley Turner8,Shelley Mason9,Munaza Ahmed10,Bryony Eccles4

1Macmillan Survivorship Research Group, Faculty of Health Sciences, Univerisity of Southampton, Southampton, UK,2Faculty of Health Sciences, Univerisity of Southampton, Southampton, UK,3Cancer Sciences Division, University of Southampton, Southampton, UK,4Clinical Trials Unit, University of Southampton, Southampton, UK,5Department of Genetic Medicine, University of Manchester, Manchester, UK,6Cancer Research UK centre, University of Southampton, Southampton, UK,7Christie Hospital NHS Trust, Manchester, UK,8University of Southampton, Primary Care and Population Sciences, Southampton, UK,9Research partner, Southampton, UK,10University Hospital Southampton NHS Foundation Trust, Wessex Department of Clinical Genetics, Southampton, UK


A mouse model of early stage tumour progression identifies genes associated with worse outcome in human Adenocarcinoma of the Lung

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Sarah Neidler1,Ann Hedley2,Kay Hewitt2,Tiziana Monteverde1,Bjorn Kruspig1,Craig Dick3,Emma Shanks2,Daniel Murphy1,2

1University of Glasgow, Glasgow, UK,2CRUK Beatson Institute for Cancer Research, Glasgow, UK,3NHS Southern General Hospital, Glasgow, UK


Peri-operative chemotherapy for Oesophageal and Gastro-Oesophageal Junction (GOJ) adenocarcinoma at the Northern Ireland Cancer Centre.

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Rebecca Goody1,Richard C Turkington1,2,Damian McManus3,Claire Harrison1,Colin Purcell1,Martin Eatock1,2

1Northern Ireland Cancer Centre, Belfast City Hospital, Belfast, UK,2Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, UK,3Department of Pathology, Belfast City Hospital, Belfast, UK


Defining the species differences in the metabolism of the EGFR inhibitor AZD9291 using transgenic models

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Lesley McLaughlin1,Colin Henderson1,Nico Scheer2,Roland Wolf1

1University of Dundee, Dundee, UK,2Taconic Biosciences GmbH, Cologne, Germany


Children’s Cancer and Leukaemia Group (CCLG) McElwain Award winner – Adamantinomatous craniopharyngioma contains senescent cells with tumour-inducing potential

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Mario Jose Gonzalez-Meljem1,Gabriela Carreno1,John Apps1,Scott Haston1,Christina Stache1,Tomas Stanley Jacques2,5,Colin Goding3,Jesus Gil4,Cynthia Lilian Andoniadou1,Juan Pedro Martinez-Barbera1

1University College London, London, UK,2University of Oxford, Oxford, UK,3Imperial College London, London, UK,4King’s College London, London, UK,5Great Ormond Street Hospital, London, UK


Moringa oleifera as an anti-cancer agent against Breast and Colorectal Cancer Cell Lines 

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Abdulrahman Al-Asmari1,Sulaiman Mansour Albalawi1,Md Tanwir Athar1,Abdul Quaiyoom Khan1,Hamoud Al-Shahrani1,Mozaffarul Islam1

1Prince Sultan Military Medical City, Riyadh, Saudi Arabia