¹University of Leeds, Leeds, UK,²Leeds Teaching Hospitals NHS Trust, Leeds, UK

¹University of Leicester, Leicester, UK

¹University of Leicester, Leicester, UK

¹Southport and Ormskirk Hospital, Merseyside, UK,²Clatterbridge Cancer Centre, Merseyside, UK

¹London Cancer, UCLPartners, London, UK,²Anglia Ruskin University, Cambridge, UK,³Barts Health, London, UK

¹Leeds Institute of Cancer and Pathology, Leeds, UK,²Affymetrix UK Ltd, High Wycombe, UK

¹The Francis Crick Institute, Laboratory of Developmental Signalling, London, UK,²The Francis Crick Institute, Bioinformatics and Biostatistics Group, London, UK

¹Oncology Department, Royal Cornwall Hospital, Truro, UK

¹QIAGEN GmbH, Hilden, Germany

¹Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands,²University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands,³Molecular and Population Genetics Laboratory, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,⁴Immunity Theme, NIHR Oxford Comprehensive Biomedical Research Centre, The Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK,⁵Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands,⁶Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands,⁷Genomic Medicine Theme, Oxford Comprehensive Biomedical Research Centre, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,⁸Oxford Cancer Centre, Churchill Hospital, Oxford, UK

¹Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK,²Edinburgh Cancer Centre, NHS Lothian, Edinburgh, UK,³Borders General Hospital, NHS Borders, Melrose, UK

¹Barts Cancer Institute, London, UK,²Guy’s and St Thomas’ Hospital NHS Trust, London, UK,³The Christie NHS Foundation Trust, Manchester, UK,⁴Beatson West of Scotland Cancer Centre, Glasgow, UK,⁵The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK,⁶University Hospital Southampton NHS Foundation Trust, Southampton, UK,⁷St James’s University Hospital, Leeds, UK,⁸Bristol Haematology and Oncology Centre, Bristol, UK,⁹Aberdeen Royal Infirmary, Aberdeen, UK,¹⁰Nottingham University Hospitals NHS Trust, Nottingham, UK,¹¹Freeman Hospital, Newcastle, UK,¹²University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK,¹³Royal Marsden Hospital, Surrey, UK

¹New York University Abu Dhabi, Abu Dhabi, United Arab Emirates

¹The University of Manchester, Manchester, UK

¹University of Leeds, Leeds, UK

¹The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK,²Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA,³University of Leicester, University Road, Leicester LE1 7RH, UK

¹UNIVERSIT OF SOUTHAMPTON, SOUTHAMPTON, UK,²KING SAUD UNIVERSITY, RIYADH, Saudi Arabia

¹School of Life Sciences, University of the West of England, Bristol, UK,²Department of Human Nutition, Foods and Excercise, Virginia Polytechnic Institute and State Universit, Virginia, USA,³Brain Tumour Research Group, University of Bristol, Bristol, UK

¹North Wales Cancer Treatment Centre, Rhyl, UK

¹The Royal Marsden NHS Foundation Trust, London and Surrey, UK

¹University Hospital Birmingham, Birmingham, West Midlands, UK, UK,²University of Delhi, Delhi, India

¹Clinical Operational Research Unit UCL, London, UK,²Clinical Trials Group UCL, London, UK,³MRC Biostastics Unit, Cambridge, UK,⁴Wales Cancer Trials Unit, Cardiff, UK,⁵Division of Surgery UCL, London, UK,⁶Imperial College, London, UK

¹University of Bedfordshire, Luton,Bedfordshire, UK,²Southampton University Hospital, Southampton, UK,³Southampton University Hospital, Southampton, UK,⁴University of Bedfordshire, Luton,Bedfordshire, UK

¹Edinburgh Cancer Centre, Edinburgh, UK,²Western General Hospital, Edinburgh, UK

¹Linkoping University, Linkoping, Sweden,²Pomeranian Medical University, Szczecin, Poland,³University of Manitoba, Winnipeg, Canada

¹Poole Hospital NHS Foundation Trust, Poole, Dorset, UK

¹North Devon District Hospital, Devon, UK

¹Beatson West of Scotland Cancer Centre, Glasgow, UK

¹University of Edinburgh medical school, Edinburgh, UK,²Edinburgh Cancer Centre, Edinburgh, UK,³NHS Lothian, Edinburgh, UK

¹Oncology Depatment, Royal Cornwall Hospital, Truro, UK,²Cheltenham General Hospital, Cheltenham, UK,³Royal Devon & Exeter Hospital, Exeter, UK

¹Clatterbridge Cancer Centre, Merseyside, UK,²Clatterbridge Cancer Centre, Merseyside, UK,³Clatterbridge Cancer Centre, Merseyside, UK

¹Faculty of Medicine Mansoura University, Mansoura, Egypt,²Faculty of Pharmacy Mansoura University, Mansoura, Egypt,³Faculty of Science Mansoura University, Mansoura, Egypt,⁴Medical Experimental Research Center, Mansoura, Egypt

¹Royal Stoke Hospital, Stoke-On-Trent, UK,²Mansoura University Oncology Centre, Mansoura, Egypt,³Mansoura University Public Health Department, Mansoura, Egypt

¹Indian Institute of Technology, Chennai, Chennai, Tamilnadu, Iceland

¹Department of Surgical Oncology, King George’s Medical University, Lucknow, Uttar Pradesh, India,²Director, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India,³Department of Radiotherapy, King George’s Medical University, Lucknow, Uttar Pradesh, India,⁴Institute for Data Computing and Training, Lucknow, Uttar Pradesh, India

¹School of Physiology and Pharmacology, University of Bristol, Bristol, UK,²Department of Urology, Southmead Hospital, Bristol, UK,³School of Social and Community Medicine, University of Bristol, Bristol, UK,⁴Department of Cellular Pathology, Southmead Hospital, Bristol, UK

¹Patient Representative, Glasgow, UK,²International Consortium for Health Outcomes Measurement, Cambridge, MA, USA,³Harvard Radiation Oncology Program, Boston, MA, USA,⁴Department of Respiratory Medicine, University Hospitals of Leicester, Leicester, UK,⁵Clinical Lead, National Cancer Intelligence Network (NCIN), Public Health England, London, UK

¹Edinburgh Cancer Centre, Edinburgh, UK

¹University of West of England, Bristol, Avon, UK

¹centre anti cancer, Blida, Algeria

¹University of Aberdeen, Aberdeen, UK,²Vertebrate Antibodies, Aberdeen, UK

¹Bupa Cromwell Hospital, London, UK

¹BSUH, Brighton, UK