793 abstracts found.



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What are the treatment-related preferences of patients with advanced cancer? A discrete choice experiment

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Mark O’Kane1,Peter Hall1,2,David Meads1,Rebecca Wright1

1University of Leeds, Leeds, UK,2Leeds Teaching Hospitals NHS Trust, Leeds, UK


Investigating a novel ERCC5 polymorphism as a biomarker of oxaliplatin effect in patients with metastatic colorectal cancer

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Joanna Wood1,Jennifer Bowdrey1,Joanna Somers1,Anne Willis1,Anne Thomas1

1University of Leicester, Leicester, UK


Assessing the feasibility of conducting a primary chemoprevention study of curcumin in young patients with FAP

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Joanna Wood1,Lynne Howells1,Karen Brown1,Anne Thomas1

1University of Leicester, Leicester, UK


Acute Oncology Service (AOS) Patient Experience Feedback Project

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Sarah Cox1,Helen Neville-Webbe2,1

1Southport and Ormskirk Hospital, Merseyside, UK,2Clatterbridge Cancer Centre, Merseyside, UK


Survival of cancer presenting through A&E affected by age, cancer and treatment intent. Findings from the London Cancer A&E Audit

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Neil Chauhan1,3,Melanie Ridge1,Michael Parker2,Kathy Pritchard-Jones1

1London Cancer, UCLPartners, London, UK,2Anglia Ruskin University, Cambridge, UK,3Barts Health, London, UK


Loss of pTEN expression is strongly associated with the presence of the BRAF V600E mutation, and further complicates combination treatment strategies for patients with advanced colorectal cancer

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Susan Richman1,Gemma Hemmings1,Phil Chambers1,Morag Taylor1,Henry Wood1,Emma Tinkler-Hundal1,Katie Southward1,Joseph Foster2,Assa Ouime2,Karen Spink2,Phil Quirke1

1Leeds Institute of Cancer and Pathology, Leeds, UK,2Affymetrix UK Ltd, High Wycombe, UK


Signalling to the epigenome: how TGF-b superfamily ligands regulate gene expression via chromatin

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Davide Martino Coda1,Tessa Gaarenstroom1,Harshil Patel2,Phil East2,Aengus Stewart2,Caroline Hill1

1The Francis Crick Institute, Laboratory of Developmental Signalling, London, UK,2The Francis Crick Institute, Bioinformatics and Biostatistics Group, London, UK


An investigation of the use and outcomes of Abiraterone and Enzalutamide in patients with metastatic prostate cancer in Cornwall.

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Stuart Walter1,Anthony Williams1,Richard Ellis1,Alastair Thomson1,Duncan Wheatley1,James Henderson1,John McGrane1

1Oncology Department, Royal Cornwall Hospital, Truro, UK


Sensitive Mutation Detection By Sequencing Circulating Cell-Free DNA

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Nan Fang1,Rumeysa Tolun1,Katja Heitz1,Colin Baron1

1QIAGEN GmbH, Hilden, Germany


POLE proofreading mutations elicit an anti-tumour immune response in endometrial cancer

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Inge van Gool1,Florine Eggink2,Luke Freeman-Mills3,Ellen Stelloo1,Emanuele Marchi4,Marco de Bruyn2,Claire Palles3,Remi Nout5,Cor de Kroon6,Elisabeth Osse1,Paul Klenerman4,Carien Creutzberg5,Ian Tomlinson3,7,Vincent Smit1,Hans Nijman2,Tjalling Bosse1,David Church3,8

1Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands,2University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands,3Molecular and Population Genetics Laboratory, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,4Immunity Theme, NIHR Oxford Comprehensive Biomedical Research Centre, The Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK,5Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands,6Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands,7Genomic Medicine Theme, Oxford Comprehensive Biomedical Research Centre, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,8Oxford Cancer Centre, Churchill Hospital, Oxford, UK


Scope for an acute oncology service in a Scottish district general hospital

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Caroline Bruce1,Allan Price2,Judith Smith3

1Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK,2Edinburgh Cancer Centre, NHS Lothian, Edinburgh, UK,3Borders General Hospital, NHS Borders, Melrose, UK


A phase II/III randomised trial comparing maintenance lapatinib vs placebo after first line chemotherapy in HER1/2 positive metastatic bladder cancer

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Simon Chowdhury2,Tony Elliot3,Robert Jones4,Syed Hussain5,Simon Crabb6,Charlotte Ackerman1,Satinder Jagdev7,John Chester7,Serena Hilman8,Mark Beresford8,Graham Macdonald9,Sundar Santhanam10,John Frew11,Andrew Stockdale12,Shah-Jalal Sarker1,Dan Berney1,Thomas Powles1,Robert Huddart13

1Barts Cancer Institute, London, UK,2Guy’s and St Thomas’ Hospital NHS Trust, London, UK,3The Christie NHS Foundation Trust, Manchester, UK,4Beatson West of Scotland Cancer Centre, Glasgow, UK,5The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK,6University Hospital Southampton NHS Foundation Trust, Southampton, UK,7St James’s University Hospital, Leeds, UK,8Bristol Haematology and Oncology Centre, Bristol, UK,9Aberdeen Royal Infirmary, Aberdeen, UK,10Nottingham University Hospitals NHS Trust, Nottingham, UK,11Freeman Hospital, Newcastle, UK,12University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK,13Royal Marsden Hospital, Surrey, UK


The Warburg Effect and Human Hexokinase 2 in Cancer Metabolism and Apoptosis.

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Hussain Mir Nawaz1,Wael Rabeh1

1New York University Abu Dhabi, Abu Dhabi, United Arab Emirates


Prognostic models in small and non-small cell lung cancer: how does survival relate to progression free survival and response?

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Hitesh Mistry0

1The University of Manchester, Manchester, UK


ETV1 and ETV5 as targets and effectors of mutant FGFR3 in bladder cancer

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Erica di Martino1,Margaret Knowles1

1University of Leeds, Leeds, UK


Idenfitication of cancer cell responses to hypoxia mediated by protein cysteine modifications

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Fiona Grimm1,Timothy J Ragan1,3,D Alexander Shannon2,Eranthie Weerapana2,Dimitrios Anastasiou1

1The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK,2Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA,3University of Leicester, University Road, Leicester LE1 7RH, UK


Methylation of Salvador-Warts-Hippo pathway in Osteosarcoma Cells

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AMAL ALENAD1,MAJED ALOKAIL2

1UNIVERSIT OF SOUTHAMPTON, SOUTHAMPTON, UK,2KING SAUD UNIVERSITY, RIYADH, Saudi Arabia


Decreased expression of the mitochondrial BCAT protein correlates with improved patient survival in IDH wild-type gliomas

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M.E. Conway1,J. Hull1,M. El Hindy1,S.C. Taylor1,F. El Amraoui1,C. Paton-Thomas1,P. White1,M. Williams3,H.R. Haynes3,S.M. Hutson2,K.M. Kurian3

1School of Life Sciences, University of the West of England, Bristol, UK,2Department of Human Nutition, Foods and Excercise, Virginia Polytechnic Institute and State Universit, Virginia, USA,3Brain Tumour Research Group, University of Bristol, Bristol, UK


Role of MASCC score in the Management of Neutropenic Sepsis at Ysbyty Glan Clwyd

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Bakhiet Osman1,Muhammad Farooq Latif1,Faisal Azam1

1North Wales Cancer Treatment Centre, Rhyl, UK


Clinical trial participation; barriers detected in a specialist cancer centre

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Alicia Okines1,Natalie Wilkinson1,Sally Gill1,Alexendros Georgiou1,Lucy Dumas1,Martin Gore1,Susana Banerjee1

1The Royal Marsden NHS Foundation Trust, London and Surrey, UK


Liver toxicity associated with the use of Pazopanib in renal cancer patients: UK teaching hospital experience

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Ankit Jain1,Cinzia Canipari1,Farzana Haque1,Heena Solanki1,Abhishek Kumar2,Emilio Porfiri1

1University Hospital Birmingham, Birmingham, West Midlands, UK, UK,2University of Delhi, Delhi, India


Intensive monitoring after resection of primary colorectal cancer advances diagnosis of liver and lung metastases but has not been shown to improve survival.

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Tom Treasure1,Chris Brew-Graves2,Sahar Mokhles2,Norman Williams2,Vern Farewell3,Fergus Macbeth4,Christopher Russell5,Francesca Fiorentino6

1Clinical Operational Research Unit UCL, London, UK,2Clinical Trials Group UCL, London, UK,3MRC Biostastics Unit, Cambridge, UK,4Wales Cancer Trials Unit, Cardiff, UK,5Division of Surgery UCL, London, UK,6Imperial College, London, UK


GKT-AML5, WT1 and SSX2IP are frequently expressed in adult B-cell acute lymphocytic leukaemia

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Payalben Savaliya1,Laurence Orchard2,Kim Orchard3,Barbara Guinn1

1University of Bedfordshire, Luton,Bedfordshire, UK,2Southampton University Hospital, Southampton, UK,3Southampton University Hospital, Southampton, UK,4University of Bedfordshire, Luton,Bedfordshire, UK


How Frail is the Oncology Inpatient Population?

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Rachel Nirsimloo1,Naomi Moodley1,Melanie Mackean1,Elizabeth MacDonald2

1Edinburgh Cancer Centre, Edinburgh, UK,2Western General Hospital, Edinburgh, UK


Nuclear Akt enhances breast cancer stem-like cells through counter-regulation of p21Waf/Cip1 and p27kip1

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Mayur Vilas Jain1,Jaganmohan R. Jangamreddy1,Jerzy Grabarek2,Frank Schweizer3,Thomas Klonisch3,Artur Cie?lar-Pobuda1,Marek J. Los1,2

1Linkoping University, Linkoping, Sweden,2Pomeranian Medical University, Szczecin, Poland,3University of Manitoba, Winnipeg, Canada


Combing a Clinical Nurse Specialist and Research Nurse role to provide integrated care for patients with prostate cancer.

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Roger Wheelwright1

1Poole Hospital NHS Foundation Trust, Poole, Dorset, UK


A REVIEW OF NORTH DEVON DISTRICT HOSPITAL MANAGEMENT OF METASTATIC SPINAL CORD COMPRESSION IN 2014

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Timothy Mitchell1,Clare Shepperd1,Vicky Ford1,Mark Meller1

1North Devon District Hospital, Devon, UK


CT staging in patients with sentinel or axillary lymph node sampling positive early breast cancer. Is there any impact on clinical outcomes?

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Ishtiaq Zubairi1,Mehmood Zaidi1,Abdulla Alhasso1,Graeme Lumsden1

1Beatson West of Scotland Cancer Centre, Glasgow, UK


Consenting for chemotherapy: do patients understand the aims of their treatment?

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Anna Kennedy1,Catherine Kitchen1,Nina Phull1,Stuart Reid1,Caitlin Riach1,Hans Siy-Yap1,Conn Talbot1,Hui Yen Teh1,Caroline White3,Sally Clive2,3

1University of Edinburgh medical school, Edinburgh, UK,2Edinburgh Cancer Centre, Edinburgh, UK,3NHS Lothian, Edinburgh, UK


A Review of Local Outcomes in Glioblastoma in Cornwall with Respect to Performance Status, Age and MGMT Methylation Status.

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Stuart Walter1,John McGrane1,Peter Rimmer2,Roy Powell3,Richard Ellis1,Carolyn Campbell1,Toby Talbot1

1Oncology Depatment, Royal Cornwall Hospital, Truro, UK,2Cheltenham General Hospital, Cheltenham, UK,3Royal Devon & Exeter Hospital, Exeter, UK


Thromboembolism in patients with localized upper Gastro-intestinal cancers undergoing radical treatment.

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Abdul Qayam1,Helen Wong1,Helen Neville-Webbe1

1Clatterbridge Cancer Centre, Merseyside, UK,2Clatterbridge Cancer Centre, Merseyside, UK,3Clatterbridge Cancer Centre, Merseyside, UK


Curcumin and its derivative as novel pharmacological treatment for human breast cancer cell line , invitro study

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Hossam Elbelasi1,4,Hossam Eid3,4,Farid Badria2

1Faculty of Medicine Mansoura University, Mansoura, Egypt,2Faculty of Pharmacy Mansoura University, Mansoura, Egypt,3Faculty of Science Mansoura University, Mansoura, Egypt,4Medical Experimental Research Center, Mansoura, Egypt


Interval or Late Debulking Surgeries in Advanced Epithelial Ovarian Cancer: Progression Free and Overall Survival Advantages

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Loaie Mohamed El-Helw1,2,Abeda Raiyan1,Hannaa Elkhenini3,Rajanee Bhana1

1Royal Stoke Hospital, Stoke-On-Trent, UK,2Mansoura University Oncology Centre, Mansoura, Egypt,3Mansoura University Public Health Department, Mansoura, Egypt


Leukemic stem cells in methotrexate resistant T cell leukemia

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Jayaprakasam Madhumathi1,Surapally Sridevi1,Rama S Verma1

1Indian Institute of Technology, Chennai, Chennai, Tamilnadu, Iceland


Oral cancer among young patients of 35 years of age and below

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Mahendra Singh1,Sanjeev Misra1,2,Vijay Kumar1,MPS Negi4,MLB Bhatt3

1Department of Surgical Oncology, King George’s Medical University, Lucknow, Uttar Pradesh, India,2Director, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India,3Department of Radiotherapy, King George’s Medical University, Lucknow, Uttar Pradesh, India,4Institute for Data Computing and Training, Lucknow, Uttar Pradesh, India


Characterising expression of the pro-angiogenic regulator serine-arginine protein kinase 1 (SRPK1) in prostate cancer

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Nicholas Bullock1,Jonathan Potts2,Andrew Simpkin3,Anthony Koupparis2,Steve Harper1,Jon Oxley4,Sebastian Oltean1

1School of Physiology and Pharmacology, University of Bristol, Bristol, UK,2Department of Urology, Southmead Hospital, Bristol, UK,3School of Social and Community Medicine, University of Bristol, Bristol, UK,4Department of Cellular Pathology, Southmead Hospital, Bristol, UK


Defining a standard set of patient-centered outcomes for patients with lung cancer

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Tom Haswell1,Kimberley S. Mak2,3,Annelotte C.M. van Bommel2,Caleb Stowell2,Michael D. Peake4,5

1Patient Representative, Glasgow, UK,2International Consortium for Health Outcomes Measurement, Cambridge, MA, USA,3Harvard Radiation Oncology Program, Boston, MA, USA,4Department of Respiratory Medicine, University Hospitals of Leicester, Leicester, UK,5Clinical Lead, National Cancer Intelligence Network (NCIN), Public Health England, London, UK


Vertebral bone biopsy: establishing diagnosis in cancer of unknown primary

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Sarah Scobie1,Sally Clive1

1Edinburgh Cancer Centre, Edinburgh, UK


The Investigation of the Regulation of the Process of Epithelial Mesenchymal Transition in Triple Negative and Basal Like Breast Cancer

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Arwa Flemban1,Anthony Rhodes1,David Qualtrough1

1University of West of England, Bristol, Avon, UK


Lapatinib With Capecitabine in Heavily-pretreated HER2- positive Metastatic Breast Cancer Progressing On Trastuzumabce

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Messaoud AYAD1,Neoual AKSIL1,Kada BOUALGA1

1centre anti cancer, Blida, Algeria


Characterisation of the oxysterol pathway in colorectal cancer

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Rebecca Swan1,Abdo Alnabulsi1,Beatriz Cash2,Ayham Alnabulsi2,Graeme Murray1

1University of Aberdeen, Aberdeen, UK,2Vertebrate Antibodies, Aberdeen, UK


Oligometastases: Is the line between radical and palliative Radiotherapy starting to blur?

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Liam Mannion1,Shyam Parmar1

1Bupa Cromwell Hospital, London, UK


Clinical Observations on Chemotherapy Curable Malignancies: Unique Genetic Events, Frozen Development and Enduring Apoptotic Potential

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Philip Savage1

1BSUH, Brighton, UK