575 abstracts found.



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The prognostic potential of the long non-coding RNA MALAT1 in M0 prostate cancer

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Kenneth Hiew1,Sivan Bokobza2,Claire Hart1,Tony Elliott3,Neil Smith2,Michael Brown1,Noel Clarke3
1Genito Urinary Cancer Research Group,2AstraZeneca,3Christie Hospital NHS Foundation Trust

PDE5 INHIBITORS CAN AMELIORATE CHEMORESISTANCE IN OESOPHAGEAL ADENOCARCINOMA CAUSED BY CANCER-ASSOCIATED FIBROBLASTS

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Clarisa Choh1,Annette Hayden1,Ewan Kyle1,Jeremy Blaydes1,Tim Underwood1
1University of Southampton

Electrophysiology of autocrine and paracrine NMDA receptor signalling in invasive mouse pancreatic neuroendocrine tumour cells

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Hugh Robinson1,Leanne Li2
1University of Cambridge,2Massachusetts Institute of Technology

Regulation of FLIP Long by the SCF(Skp2) ubiquitin ligase complex

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Jamie Roberts1,Caitriona Holohan1,Joel Riley2,Joanna Majkut1,Patrick Johnston1,Paul Moynagh3,Daniel Longley4
1Queen's University Belfast,2University of Glasgow,3Univerisity of Maynooth,4Queen's Univeristy Belfast

Therapeutic compound discovery and validation of drugs targeting a recurrent glioblastoma (GBM) phenotype using LINCS compounds via QUADrATiC analyses

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Shahnaz Al Rashid1,Paul O'Reilly1,Philip Dunne1,Matthew Alderdice1,Thomas Flannery1,Kevin Prise1,Shu-Dong Zhang1,Darragh McArt1
1Queen's University Belfast

BCL3 and radiation sensitivity in rectal cancer

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Adam Chambers1,Alex Greenhough1,Rhys Morgan1,Danny Legge1,Eleanor Mortensson1,Tracey Collard1,Chris Paraskeva1,Michael Thomas2,Ann Williams1
1University of Bristol,2University Hospital Bristol

Frizzled receptor 4 (FZD4) is associated with patient survival, invasiveness and tumour formation capacity in epithelial ovarian cancer

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Nair Bonito1,Wei Dai2,Robert Brown1
1Imperial College London,2The University of Hong Kong (HKU)

Downregulation of the citrullinating enzyme Peptidyl-arginine deiminase type-2 in ovarian cancer indicates poor prognosis

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Lee Machado1,Paul Moseley2,Robert Moss2,Suha Deen2,Christopher Nolan2,Ian Spendlove Spendlove2,Judith Ramage2,Stephen Chan2,Lindy Durrant2
1University of Northampton,2University of Nottingham

Genome-wide gene expression changes in KSRP silenced breast cancer cells

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Raquel Duarte1,Kiashanee Moodley1,Caroline Dickens1,Valcarcel Juan2
1University of the Witwatersrand,2Centre for Genomic Regulation

Development of a Novel Cellular Assay For Assessing Protein:Protein Interactions (PPIs) Between Extrinsic Apoptosis Proteins

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Luke Humphreys1,Catherine Higgins1,Joanna Majkut1,Timothy Harrison1,Daniel B. Longley1
1Cell Death and Drug Resistance Group, Centre For Cancer Research and Cell Biology, Queens University, Belfast

Targeting NEDDylation in Colorectal Cancer

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Jennifer Ferris1,Jennifer Ferris2,Caitriona Holohan3,Alexander McIntyre3,Simon McDade3,Daniel B Longley3,Vicky Coyle3
1Centre of Cancer Research and Cell Biology,2Cell Death & Drug Resistance Group, Centre for Cancer Research & Cell Biology, Queen’s University Belfast,3Centre of Cancer Research and Cell Biology, QUB

The dual mTORC1/2 inhibitor, AZD2014, potentiates the efficacy of palbociclib, a CDK4/6 inhibitor, in ER+ breast cancer.

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Anna Staniszewska1,Chrysiis Michaloglou1,Claire Crafter1,Urszula Polanska1,Oona Delpuech1,Jon Curwen1,Mandy Lawson1,Larissa Carnevalli1,Michael Dymond1,Robert McEwen1,Sabina Cosulich1
1Astra Zeneca

A Possible Mechanism for Cells from Normal to Cancer?

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Huiwu Li1,Hui Li2,Haifeng Wang3,Ling Liu4
1Vice director of Tumor Research and Prevention Institute in Tumor Hospital,2Central Laboratory of Xinjiang Medical University, 393 Xinyi Rd., Urumqi, Xinjiang 830054, P.R.China,3Department of Thoracic Surgery, Third Affiliated Hospital, Xinjiang Medical University,4Basic Medicine School, Xinjiang Medical University

Assessment of EGFR Modulation in HPV negative Head and Neck Cancer Cells and The effect on Response to Targeted Therapies

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Elham Alsahafi1,Mahvash Tavassoli1
1Kings College London

Ex-vivo prostate culture utilising ‘PEOPLE’ – PatiEnt prOstate samPLes for rEsearch

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Susan Heavey1,Hayley Pye1,Lina Carmona Echeverria1,Greg Shaw2,Alex Freeman2,Marzena Ratynska2,Charles Jameson2,Helena Costa1,Sophia Jenkinson1,Georgina Lewis1,John Kelly2,Andrew Feber1,Hayley Whitaker1
1UCL,2UCLH

CRUK:Manchester Institute’s Drug Discovery Unit’s Focus on Success

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Gemma Hopkins1,Graeme Walker1,Mandy Watson1,Nikki March1,Allan Jordan1,Ian Waddell1,Donald Ogilvie1
1CRUK:Manchester Institute

Role of Protein Phosphatase 4 Regulatory Subunits in Myeloid Leukaemia

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Mirna Mourtada-Maarabouni1,Robert Hanson1,Cyntura Sivanandan1,Alicja Ladna1
1Keele University

Genomic patterns in low-grade prostate cancer indicative of upgrading

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Salpie Nowinski1,Jelmar Quist1,Trevor Graham2,Massimo Loda3,Mieke Van Hemelrijck1,Anita Grigoriadis1
1King's College London,2Queen Mary University London,3Dana-Farber Cancer Institute

Lifetime BMI trajectory classes and obesity-related cancer risk in a US retrospective cohort study

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Hannah Lennon1,Matthew Sperrin1,Andrew Renehan1
1University of Manchester

UK Healthcare Professional Knowledge and Understanding of the Impact of Cancer Treatment Induced Oral Mucositis: A Delphi Consensus Study

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Latha Parvataneni1,Oona Tillotson1,Ian Smyth2,Ayse Ibrahim3,Rosie Bougoffa2,Michael Dobson4
1Colonis Pharma Ltd,2Mednet Ltd,3Mednet Consult,4Colonis Pharma Limited

Staff Awareness Of Oncology and Haematology Clinical Trials (OHCT) – Bridging The Information Gap

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Emma Mcmunagle1,Yasmine Yau1
1Guy's and St Thomas's NHS Foundation Trust

Combining the PI3Kβ/δ inhibitor, AZD8186, with the dual mTORC1/2 inhibitor, Vistusertib, gives increased anti-tumour effects in PTEN-deficient tumours.

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Urszula Polanska1,James Lynch1,Urs Hancox1,Oona Delpuech1,Robert McEwen1,James Bradford2,Antonio Garcia-Trinidad1,Radoslaw Polanski1,Alvaro Avivar-Valderas1,James Pilling1,Juliana Maynard1,Carol Lenaghan1,Anna Staniszewska1,Cath Eberlein1,Cath Trigwell1,Marie Cumberbatch1,Susan Critchlow1,Francisco Cruzalegui1,Simon Barry1
1AstraZeneca,2University of Sheffield

Coffee consumption and risk of pancreatic cancer among non-smokers in the Million Women Study

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Charlie Zhou1,Ai-Seon Kuan2,Gillian Reeves2,Jane Green2,Valerie Beral2,TienYu Owen Yang2
1Royal Free NHS Foundation Trust,2Nuffield Department of Population Health, University of Oxford

Factors associated with recurrence and survival length following relapse in patients with neuroblastoma

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Nermine Basta1,Gail Halliday2,Guy Makin3,Jillian Birch4,Richard Feltbower5,Nick Bown6,Martin Elliott7,Lucas Moreno8,Guiseppe Barone8,Andrew Pearson8,Peter James1,Deborah Tweddle2,Richard McNally1
1Institute of Health & Society, Newcastle University,2Northern Institute for Cancer Research, Newcastle University and Department of Paediatric Oncology, The Great North Children's Hospital, Newcastle upon Tyne,3Institute of Cancer Sciences, University of Manchester & Department of Paediatric Oncology, Royal Manchester Children's Hospital,4Institute of Cancer Sciences, University of Manchester,5Division of Epidemiology and Biostatistics, University of Leeds,6Institute of Genetic Medicine, Newcastle University,7Paediatric Oncology and Haematology Department, Leeds Teaching Hospitals NHS Trust,8Children and Young People's Unit, Royal Marsden NHS Foundation Trust and Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, Sutton

Reducing Heart Toxicity In Medulloblastoma Using Proton Therapy

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Abdossalam Madkhali1,Mike Partridge1
1University of Oxford