581 abstracts found.



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Discovery of potent, selective and orally bioavailable CDK8/CDK19 kinase modulators

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Aurélie Mallinger,1 Kai Schiemann,2 Christian Rink,1 Frank Stieber,2 Simon Crumpler,1 Mark Stubbs,1 Olajumoke Adeniji-Popoola,1 Oliver Poeschke,2 Michael Busch,2 Paul Czodrowski,2 Djordje Musil,2 Daniel Schwarz,2 Maria-Jesus Ortiz-Ruiz,1 Richard Schneider,2 Melanie Valenti,1 Alexis de Haven Brandon,1 Rosemary Burke,1 Paul Workman,1 Trevor Dale,3 Dirk Wienke,2 Paul Clarke,1 Christina Esdar,2 Florence Raynaud,1 Suzanne Eccles,1 Felix Rohdich2 and Julian Blagg1

1The Institute of Cancer Research, London 2Merck KGaA, Darmstadt, Germany 3School of Bioscience, Cardiff University

Focal Adhesion Kinase – a new target in cancer immunotherapy

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Alan Serrels1

1MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh

TRACERx – TRAcking non-small cell lung Cancer Evolution through therapy (Rx)

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Mariam Jamal-Hanjani1

1UCL Cancer Institute

An evaluation of the microvessel density (MVD) as a prognostic biomarker in adenocarcinoma of prostate

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Iolia Akaev1,Laura Porcza1,Anzhela Krol2,Lemke Solomon3,Yoodhvir Nagar4,Neerja Agrawal2,Mridula Chopra1

1University of Portsmouth,2Department of Cellular Pathology, Queen Alexandra Hospital, Portsmouth,3Department of Urology, Queen Alexandra Hospital, Portsmouth,4Department of Oncology, Queen Alexandra Hospital, Portsmouth

Investigation into the Role of Protein Phosphatase 4 Regulatory Subunits in Leukaemia

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Mirna Mourtada-Maarabouni1,Mathilda Abou Faycal Abou Faycal2,Assem Elkak2,Anwar Hasan1
1Keele University,2Lebanese University

PARKIN protein expression and its impact on the survival of patients with advanced colorectal cancer

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Claudia Caroline Veloso da Silva1,Rosimeri Kuhl Svoboda Baldin2,Nayanne Louise Costacurta1,Amanda Pereira Agostinho1,Márcia Olandosk1,Lúcia de Noronha1,Vanessa Santos Sotomaior1
1Pontifícia Universidade Católica do Paraná,2Hospital de Clínicas da Universidade Federal do Paraná (HC-UFPR)

Tracking Renal Cancer Evolution reveals deterministic routes to tumour progression

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Kevin Litchfield1
1The Francis Crick Institute

Epigenetic sensitization of non-small cell lung cancer to 5-Fluorouracil

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Israa Al-Humairi1
1University of LIverpool

Reactive Oxygen Species (ROS) modulation as a strategy to improve chemo-sensitivity in homologous recombination stratified epithelial ovarian cancer

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Chandan Mondal1,Chandan Mondal2,Eswara Murali Satyavarapu3,Chitra Mandal3
1Tata Medical Center and Tata Translational Cancer Reseach Center, Kolkata,2Tata Medical Center,3CSIR-Indian Institte of Chemical Biology

Retinoid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma, breast cancer and renal carcinomas: mRNA expression pattern

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Julius Brtko1,Lucia Bialesova1,Vladimir Lenko2,Stefan Galbavy3,Jan Podoba3,Dana Macejova1
1Institute of Experimental Endocrinology, BMC, Slovak Academy of Sciences, Bratislava,2University Hospital, Bratislava,3Saint Elizabeth Institute of Oncology, Bratislava

Investigating the effect of combination therapy on cetuximab inhibition of epidermal growth factor receptor signalling combined with dynamin inhibition in head and neck cancer squamous cell carcinoma

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Hui Yi Chew1,Adam McCluskey2,Phillip Robinson3,Benedict Panizza4,James Wells1,Riccardo Dolcetti1,Fiona Simpson1
1The University of Queensland Diamantina Institute, Brisbane, Queensland,2Centre for Chemical Biology, Chemistry, University of Newcastle, Callaghan, NSW,3Cell Signalling Unit, Children's Medical Research Institute, University of Sydney, NSW,4Department of ENT Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Queensland

Effect of cAMP on the migration, proliferation, invasion and trans-endothelial migration of Neuroblastoma cells

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Rabiu Fage Inuwa1,John Quayle2,Diana Moss2
1Institute of Translational Medicine, University of Liverpool,2Department of cellular and molecular physiology, University of Liverpool

Novel method for studying the in-vitro effects of anti-cancer agents: the assay of thymidine kinase 1 (TK1) in cell culture utilising AroCell TK 210 ELISA

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Kiran Kumar Jagarlamudi1,Liya Wang2,Staffan Eriksson3
1AroCell AB www.arocell.com,2Swedish Agricultural University,3Swedish Agricultural University, AroCell AB

Apoptosis-inducing therapeuticals promote ectodomain shedding of hypoxia-regulated carbonic anhydrase IX

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Michal Pastorek1,Ivana Vidlickova2,Miriam Zatovicova2,Silvia Pastorekova2
1Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic,2Department of Molecular Medicine, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovak Republic

Targeting FOXM1 as a therapeutic strategy in cancer

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Rebecca Downing1,Marta O. Freitas1,Wai Yiu Tse1,Sarah A. Martin1
1Barts Cancer Institute

The role of Senataxin in radiobiological hypoxia

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Shaliny Ramachandran1,Pedro Victori1,Iosifina Foskolou1,Katarzyna Leszczynska1,Kienan Savage2,Ester Hammond1
1University of Oxford,2Queen’s University Belfast

Overcoming resistance to arginine deprivation therapy in Malignant Pleural Mesothelioma

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Marta Freitas1,Peter Szlosarek1,Sarah A. Martin1
1Barts Cancer Institute

Non-Random Mis-Segregation of Human Chromosomes.

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Sarah McClelland1,Joseph Worrall2,Naoka Tamura1,Alice Mazzagatti1,Nadeem Shaikh1,Tineke van Lingen1,Bjorn Bakker3,Elina Vladimirou4,Floris Foijer3
1Barts Cancer Institute,2Barts Cancer Institute, Queen Mary University of London,3ERIBA,4UCL Cancer Institute

Can CRISPR/Cas9 screens find new synthetic lethal targets for cancer ?

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Jon Moore1
1Horizon Discovery

[10]-gingerol increases doxorubicin antitumoural and antimetastatic activity while decreases its undesired side effects in a triple negative breast cancer mouse model

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Ana Carolina Martin1,Rebeka Tomasin1,Marina Naves1,Angelica Graminha1,Liany Luna-Dulcey1,Ramon Teles1,Marcia Cominetti1
1Federal University of São Carlos

Validation of putative metastasis suppressor genes identified by an in vivo functional shRNA screen in a triple-negative breast cancer model

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Rebeka Tomasin1,Richard Redvers2,Marcia Cominetti1,Kaylene Simpson3,Robin Anderson2
1Federal University of São Carlos,2Olivia Newton John Cancer Research Institute,3Peter MacCallum Cancer Centre - Victorian Comprehensive Cancer Research Institute

Human aldehyde dehydrogenase 7A1 (ALDH7A1) expression affects cancer cell proliferation, migration and cell protection against oxidative stress

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Lina Elsalem1,Anaxagoras Fotopoulos2,Simon Allison3,Jan Moreb4,Zoe Cournia2,Klaus Pors5
1Jordan University of Science and Technology,2Biomedical Research Foundation,3University of Huddersfield,4Hematological Malignancies,5University of Bradford

Genetically encoded photocrosslinking amino acids for in-cell kinase substrate identification

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Khalil Davis1,Joanna Kelly1,Silvia Martini1,Aaron Borg1,David Mann2,Alan Armstrong2,Peter Parker1
1The Francis Crick Institute,2Imperial College London

A Predictive model of ‘on target’ drug resistance

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Daniel O'Neill1,Mike Firth1,Maryam Clausen1,Jonathan Wrigley1,Emanuela Cuomo1
1AstraZeneca

Development of first-in-class USP7 inhibitors using structure-based design

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Andrew Turnbull1,Stephanos Ioannidis2,Wojciech Krajewski3,Adan Pinto-Fernandez4,Claire Heride5,Agnes Martin3,Louise Tonkin3,Elizabeth Townsend2,Shane Buker2,David Lancia Jr.2,Christopher Dinsmore2,Tim Hammonds3,Sunkyu Kim2,Sylvie Urbe5,Michael Clague5,Benedikt Kessler4,David Komander6
1cancer research technology ltd,2FORMA Therapeutics,3CRUK Therapeutic Discovery Laboratories,4Oxford University,5Liverpool University,6Medical Research Council Laboratory of Molecular Biology

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

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Sandra Van Schaeybroeck1,Nicholas Forsythe1,Alaa Refaat1,Arman Javadi1,Hajrah Khawaja1,Jessica-Ann Weir1,Heba Emam1,Wendy Allen1,Frank Burkamp2,Vlad Popovici3,Puthen Jithesh4,Claudio Isella5,Melissa Labonte1,Ian Mills1,Patrick Johnston1
1Queen's University Belfast,2Almac Discovery Laboratories,3Masarykova Univerzita,4Sidra Medical and Research Centre,5University of Torino School of Medicine

The RalB small GTPase-SEC5 effector complex regulates survival of RAS mutant colorectal cancer by regulating trafficking of DR5

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Hajrah Awais Khawaja1,Emma Evergren1,Jamie Roberts1,Daniel Longley1,Paul O'Reilly1,Darragh McArt1,Patrick Johntson1,Timothy Harrison1,Sandra Van Schaeybroeck1
1Queen's University Belfast

“I knew things were changing and I couldn’t figure it out”: the BRAin tumour Early Detection (BRAcED) study – implications for public awareness and GP education

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Fiona Walter1,Clarissa Penfold1,Alexis Joannides1,William Sage1,Andrew Brodbelt2,Michael Jenkinson3,Stephen Price4,Colin Watts5,Joyce Bell6,Margaret Johnson6,Willie Hamilton7
1University of Cambridge,2Consultant neurosurgeon, The Walton Centre, Liverpool,3Clinical Senior Lecturer in Neurosurgery, University of Liverpool,4Cambridge Neuroscience, University of Cambridge,5Consultant Neurosurgeon, University of Cambridge,6PPI c/o University of Cambridge,7University of Exeter

Is This As Good As It Gets? The English Cancer Patient Experience Survey 2016 – Research Discussions Reported by Patients Since 2012

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Richard Stephens1,Carolyn Morris1,Mat Baker1
1NCRI

Better Conversations – Better Care : Evaluation of Training within the Serious Illness Care Programme UK

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Anita Roberts1,Alison Coakley2,Helen Bonwick3,Andrew Khodabukus4,Susan Block5,Justin Sanders5,Francine Maloney5,Jo Paladino5,Tamsin McGlinchey1,Maria Maguire2,Stephen Mason1,Peter Kirkbride2,John Ellershaw1
1University of Liverpool,2Clatterbridge Cancer Centre,3Marie Curie Cancer Care,44Royal Liverpool and Broadgreen University Hospitals NHS Trust,5Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Ariadne Labs, Boston, MA

Describing the Three Cancer Groups

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Rachel White1,Jane Maher1
1Macmillan Cancer Support

Open to change – a success story: the north manchester macmillan palliative care support service

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Niamh Lyons1,Kelly Singh2
1Macmillan Cancer Support,2ICF Consulting

LIVERPOOL, NOVEMBER 2017 Exposure to chemotherapy induces epigenetic damage in normal cells in childhood cancer survivors

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Jill McKay1,Linda Sharp1,John Casement1,Gordon Strathdee1
1Newcastle University

Dissecting the Ubiquitination function of the metastasis-promoting protein Podocalyxin

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Mohammed A. Mansour1
1Cancer Research UK Beatson Institute

Improving Service Delivery for Patients with Metastatic Renal Cancer (mRCC): A Collaboration Between The Christie NHS Foundation Trust, Manchester and Pfizer Ltd

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Tom Waddell1,Shien Chow1,Andrea Spencer-Shaw1,Nicola Hill1,Rachel Monkhouse1,Robert Hawkins1,Fiona Thistlethwaite1
1Christie NHS Foundation Trust

Updated ‘two-week wait’ referral guidelines have not improved colorectal cancer detection rates.

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Christopher Jones1,Robert Longman1
1Bristol Royal Infirmary

Can the 321 triage system reduce the number of late referrals for familial cancer syndromes

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Mathew Storey1,Julian Barwell2,Neeta Lakhani3
1Hull and East Yorkshire Hospitals NHS Trust,2University of Leicester,3South Thames Deanery

Acceptability of commercial and health data for the purpose of cancer symptom surveillance

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Hanna Skrobanski1,James Flanagan2,Xin Shi3,Yasemin Hirst4
1University of Surrey,2Imperial College London,3Manchester Metropolitan University,4University College London

A Chemotherapy Digital app can improve monitoring of toxicity and support patients on treatment

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Kerrie Fleming1,Sheena Khanduri1
1Royal Shrewsbury Hospital

Carer perspectives of the value of specialist residential weekends for young people with cancer

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Ana Martins1,Rachel M Taylor1,Sue Morgan2,Jennie Bradley3,lorna A Fern1
1University College London Hospitals NHS Trust,2Leeds Teaching Hospitals NHS Foundation Trust,3Quality Health

A Digital Health CNS Can Improve Monitoring of Chemotherapy Toxicity and Promote Self Care

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Kerrie Fleming1,Kerrie Fleming1
1Royal Shrewsbury Hospital

The feasibility and acceptability of using text-messages to safety-net patients with low risk cancer symptoms in GP primary care

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Yasemin Hirst1,Anita Lim2
1UCL,2Queen Mary University of London

Characteristics and outcomes of older women with breast cancer undergoing breast reconstruction: Analysis of the Age Gap Trial

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Irene Athanasiou1,Malcolm Reed2,Anne Shrestha3,Kwok Leung Cheung4,Riccardo Audisio5,Lynda Wyld3
1Doncaster and Bassetlaw Teaching Hospitals,2Brighton and Sussex Medical School,3University of Sheffield,4School of Medicine, University of Nottingham,5University of Liverpool

Radium 223 – Early Beatson Experience

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Norma Sidek1,Azmat Sadozye1,Abdulla Alhasso1,Jan Wallace1,Balaji Venugopal1,Stephen McKay1,Ross Carruthers1,Carolynn Lamb1,David Dodds1,Gail Buchanan1,Gerry Gillian2,Almudena Cascales1,Iain Kerr2,Caroline Findlay2,Hilary Glen1,Nicholas MacLeod1,Rob Jones1,Martin Russell3
1Beatson West of Scotland Cancer Centre,2Gartnavel General Hospital,3Forth Valley Royal Hospital

Carers of teenagers and young adults with cancer have unmet information and support needs

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Ana Martins1,Lorna Fern2,Jeremy S Whelan1,Rachel M Taylor1
1University College London Hospitals NHS Trust,2

Identifying common experiences amongst sarcoma patients. The first phase in developing a sarcoma-specific patient-reported outcome measure

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Ana Martins1,Lesley Storey2,Mary Wells3,Lorna Fern4,Lindsey Bennister5,Craig Gerrand6,Maria Onasanya7,Julie Woodford8,Rachael Windsor1,Jeremy S Whelan1,Rachel M Taylor1
1University College London Hospitals NHS Trust,2Queens University,3University of Stirling,4,5Sarcoma UK,6Newcastle Upon Tyne Hospitals NHS Foundation Trust,7Patient Representative,8Royal National Orthopaedic Hospital

A nested case-control study of circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

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Crystal Lin1,Aurora Perez-Cornago2
1University of Oxford,2

Initial characterisation of the alkyl DNA adductome in human colorectal DNA by mass spectroscopic analysis of MGMT tryptic peptides

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Rasha Abdelhady1,Geoffrey Margison1,Perdita Barran2,David Wiliams3,Andrew Povey1
1Centre for Occupational and Environmental Health, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology Medicine and Health, Ellen Wilkinson Building, University of Manchester, Oxford Road, Manchester M13 9PL,2The Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Princess Street, Manchester M1 7DN,3Centre for Chemical Biology, Department of Chemistry, Faculty of Science, University of Sheffield, Western Bank, Sheffield S10 2TN

Age-related and socio-economic inequalities in treatment receipt and survival in lung cancer

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Sam McDonald1,Louise Hayes1,Linda Sharp1
1Newcastle University

A retrospective analysis of the impact of socioeconomic deprivation on the uptake of colorectal cancer screening

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Nikhil Pawa1,Nikhil Lal1,Paul Sullivan2,Azeem Majeed3
1University of Liverpool,2Chelsea and Westminster Hospital,3Imperial College, London