661 abstracts found.



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Effective chemoprevention strategies in APC driven mouse models of intestinal tumourigenesis

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Michael Hodder1,Patrizia Cammareri1,Dennis Timmerman1,Owen Sansom1

1CRUK Beatson Institute

E-cigarettes as a Smoking Cessation aid in Cancer Patients: Health Professionals knowledge, attitude and current practice

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Jo Brett1,Fiona Matley2,Emma Davies1,Paul Aveyard3,Mary Wells4,David Foxcroft1,Brian Nicholson3,Lesley Sinclair5,Shiroma De Silva Minor6,Sarah Jakes7,Eila Watson1

1Oxford Brookes University,2Oxford Brooke University,3University of Oxford,4Imperial College Healthcare NHS Trust,5University of Stirling,6Oxford University Hospitals NHS Trust,7New Nicotine Alliance

Living with and beyond cancer top research priorities in the UK – priority setting partnership

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Feng Li1,Ian Lewis1,Adrienne Morgan2,Angela McCullagh1,Anne Johnson3,Ceinwen Giles4,Diana Greenfield5,Graeme Crawford6,Jacqui Gath2,Jane Lyons7,Jervoise Andreyev8,Jonathan Tobutt9,Julia Tugwell1,Karen Robb10,Laura Cove-Smith11,Lindsey Bennister12,Natalie Doyle13,Nicolas Lee14,Rebecca Nash14,Richard Simcock15,Richard Stephens1,Sabine Best16,Stuart Griffiths1,Susan Moug17,Sandra Regan18,Patricia Ellis18

1National Cancer Research Institute,2Independent Cancer Patients’ Voice,3Velindre NHS Trust,4Shine Cancer Support,5Sheffield Teaching Hospitals NHS Foundation Trust,6Bangor Health Centre,7Cancer 52,8United Lincolnshire Hospitals NHS Trust,9Kirkwood Hospice, Huddersfield,10Transforming Cancer Services Team in London,11The Christie NHS Foundation Trust,12Sarcoma UK,13The Royal Marsden NHS Foundation Trust,14Macmillan Cancer Support,15Brighton and Sussex University Hospital Trust,16Marie Curie,17Royal Alexandra Hospital Paisley, NHS Greater Glasgow and Clyde,18The James Lind Alliance

Investigating causal relationships between sleep characteristics and risk of breast cancer: a Mendelian randomization study

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Rebecca Richmond1,Emma Anderson1,Hassan Dashti2,Samuel Jones3,Jacqueline Lane2,Caroline Relton1,Marcus Munafò4,Debbie Lawlor1,Martin Rutter5,Richa Saxena2,Mike Weedon3,Richard Martin1,George Davey Smith1

1University of Bristol,2Massachusetts General Hospital, Boston,3University of Exeter,4University of Bristol, UK,5University of Manchester

Recurrence rates after low dose radioiodine ablation for differentiated thyroid cancer within the NCRI HiLo trial.

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Jon Wadsley1,Hakim-Moulay Dehbi2,Ujjal Mallick3,Kate Newbold4,Clive Harmer5,Allan Hackshaw2

1Weston Park Hospital,2University College London, UK,3Freeman Hospital, Newcastle upon Tyne, UK,4Royal Marsden Hospital, Sutton, UK,5Formerly of the Royal Marsden Hospital, Sutton

Evaluating the trade-offs men with localised prostate cancer make between the risks and benefits of treatments: The COMPARE study

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Hashim U. Ahmed1,Verity Watson2,Neil McCartan3,Nicolas Krucien2,Victor Abu4,Divine Ikenwilo2,Mark Emberton3

1Imperial College London,2Health Economics Research Unit, University of Aberdeen,3Research Department of Urology, Division of Surgery and Interventional Science, Faculty of Medicine, University College London,4Health and Social Care, Adult Nursing, London South Bank University

Trends in mortality from malignant melanoma: an observational study of the World Health Organisation mortality database from 1985 to 2015

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Dorothy Yang1,Justin Salciccioli2,Dominic Marshall3,Joseph Shalhoub4

1Royal Free London NHS Foundation Trust,2Department of Medicine, Mount Auburn Hospital,3Oxford University Clinical Academic Graduate School, John Radcliffe Hospital,4Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London

Socio-demographic variation in stage at diagnosis and its population impact: How many cancer patients would be diagnosed at an earlier stage if socio-demographic inequalities were eliminated?

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Matthew Barclay1,Gary Abel2,Brian Rous3,David Greenberg3,Georgios Lyratzopoulos4
1University of Cambridge,2University of Exeter,3Public Health England,4University College London

ICEC0942, a new oral selective inhibitor of the cell cycle and transcriptional regulator CDK7 for the treatment of breast and other cancers

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Simak Ali1
1Imperial College London

A systematic review of eligibility criteria for phase II clinical trials for patients with lung cancer

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Gary Doherty1,Innocent Ogunmwonyi2,Rohan Shotton1
1Cambridge University Hospitals NHS Foundation Trust,2University of Cambridge

Delays in primary care are associated with a late stage and worse prognosis for colorectal cancer patients: A population based study

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Chanpreet Arhi1,Elaine Burns1,Alex Bottle1,George Bouras1,Paul Aylin1,Paul Ziprin1,Ara Darzi1
1Imperial College London

Introduction of treatment summaries and holistic needs assessments for teenagers and young adults after cancer treatment in Scotland: a national feasibility study.

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Angela Edgar1,Nicola Davison1,Simita Kumar1,Bernadine Wilkie1,Jeff White2
1NHS Lothian,2NHS Greater Glasgow and Clyde

Living with and beyond cancer: Self-managing chemotherapy side-effects and eating behaviours

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Gianina-Ioana Postavaru1,Hilary McDermott2,Fehmidah Munir2,Tanweer Ahmed3
1Bishop Grosseteste University,2Loughborough University,3United Lincolnshire Hospitals NHS Trust

Investigating the effects of dietary and physical activity interventions on the metabolome of men with prostate cancer: The PrEvENT randomised controlled trial

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Meda R. Sandu1,Diana L. Santos Ferreira1,Rebecca Richmond1,Lucy Hackshaw-McGeagh1,Rhona Beynon1,Richard M. Martin2,J Athene Lane1
1University of Bristol,2university of Bristiol

Understanding the links between mutations in the BAF/PBAF chromatin-remodeling complexes and expression in Kidney ccRCC cancer

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Noora Al-Muftah1
1Qatar Foundation

PIXdb: Exploring the transcriptomic landscape of prostate cancer development and progression

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Helen Ross-Adams1,Jacek Marzec1,Stefano Pirro1,Yong-Jie Lu1,Claude Chelala1
1Barts Cancer Institute, QMUL

Quantifying under-treatment in older adult lung cancer patients in Northern Ireland

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Abdulqadr Akinoso-Imran1,Finian Bannon1
1Queen's University Belfast

Polyphenols Act Synergistically with Doxorubicin and Etoposide in Leukemia Cell Lines.

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Amani Mahbub1,Nicola Jordan-Mahy2,Neil Cross2,Christine Le Maitre2,Sarah Haywood-Small2
1Umm Al Qura University,2Sheffield Hallam University

Challenges in Managing the Immune Related Toxicities of Cancer Immunotherapy

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Paul Nathan1
1Mount Vernon Hospital

Methodological issues in precision oncology trials

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Lucinda Billingham1
1Cancer Research UK Clinical Trials Unit, University of Birmingham

Tumour microenvironment and radiation – friend or foe?

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Kaye Williams1
1University of Manchester

Strategic Bioassay guided fractionation – Isolation and characterization of novel, systematic, potent antiangiogenic molecules from seaweed associated actinomycetes

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Meenakshi Sundaram K1,Vincent S1,SUVRO Chatterjee2
1LOYOLA INSTITUTE OF FRONTIER ENERGY,2AUKBC, ANNA UNIVERSITY

Late recurrence of Human Papilloma Virus positive oropharyngeal cancer with very poor prognosis: a caveat in the move to de-escalation

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Helen Joyce1,Hannah Crane2,Fawzia Tahir1,Keith Hunter2,Bernadette Foran1
1Sheffield Teaching Hospitals,2University of Sheffield

Role of DYRK2 in invasive ductal carcinoma of the breast

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Jean Quinn1,Phungern Khongthong1,Donald McMillan1,Laureano de la Vega2,Joanne Edwards1
1university of glasgow,2university of Dundee

Epithelial Notch1 drives metastasis by controlling neutrophil chemotaxis in a novel late stage colorectal cancer genetically engineered mouse model

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Rene Jackstadt1
1CRUK Beatson Institute

ATHENA (GOG-3020/ENGOT-ov45): a randomised, double-blind, placebo-controlled, phase 3 study of rucaparib + nivolumab following front-line platinum-based chemotherapy in ovarian cancer

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Rebecca S. Kristeleit1,Iain A. McNeish2,Roshan Agarwal3,Susana Banerjee4,Clare Barlow5,Michelle Ferguson6,Maxine Flubacher7,Marcia Hall8,Rebecca Herbertson9,Jane Hook10,Rachel Jones11,Louise Li12,Fiona Lofts13,Rowan E. Miller14,Sarah Moon15,Shibani Nicum16,Fiona Nussey17,Christine Parkinson18,Justin Waters19,Isabella Capobianco20,Sandra Goble20,Nikolay Grechko20,Bradley J. Monk21
1University College London Cancer Institute, UCL,2Imperial College London,3Northampton General Hospital,4The Royal Marsden NHS Foundation Trust,5Musgrove Park Hospital,6Ninewells Hospital & Medical School,7Poole Hospital NHS Foundation Trust,8Mount Vernon Cancer Centre,9Royal Sussex County Hospital,10St James’s University Hospital,11South West Wales Cancer Centre,12The James Cook University Hospital,13St George’s Hospital,14St. Bartholomew's Hospital, Barts Health NHS Trust,15Morecombe Bay NHS Trust, Lancaster,16Oxford Cancer Centre,17Edinburgh Cancer Centre, Western General Hospital,18Addenbrookes Hospital, Cambridge,19East Kent Hospitals University NHS Foundation Trust,20Clovis Oncology, Inc.,21Arizona Oncology (US Oncology Network), University of Arizona College of Medicine, Creighton University School of Medicine

MR-Elastography of the breast: Initial experience with a novel transducer system

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Sweta Sethi1,Stefan Heinz Hoelzl2,Ayse Sila Dokumaci2,Christian Guenthner3,Daniel Fovargue2,David Nordsletten2,Arnie Purushotham2,Ralph Sinkus2
1Guy's and St.Thomas' NHS Foundation Trust,2King's College London,3University and ETH Zurich

RhoB as a novel molecular target for chemotherapy of colorectal cancer

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Maria Kopsida1
1Linkoping University

Investigating the role of rho kinase in the survival of CML cells

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Leena Mukherjee1,Cassie Clarke1,Heather Jorgensen1,Mhairi Copland1,Mike Olson2,Tessa Holyoake1
1University of Glasgow,2Ryerson University

Management squamous cell carcinoma unknown primary head and neck (SCCUP) using contemporary diagnostic and radiotherapy (RT) techniques

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Claire Paterson1,Robin Crosbie1,Philip McLoone2,Derek Grose1,Allan James1,Carolynn Lamb1,Mohammed Rizwanullah3,Stefano Schipani1,Christina Wilson1,Frances Campbell1,Fiona Easton4,Maureen Thomson1
1NHS,2University of Glasgow,3N/A,4CRUK

Automated brachytherapy seed counting with multimodal image registration on trained deep learning convolutional neural network

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Rollo Moore1,Rollo Moore1,Ladislav Urban2,Yae-eun Suh3,Kate Roberts4,Derfel Ap Dafydd1,Vincent Khoo1
1The Royal Marsden NHS Foundation Trust,2Dynocortex,3The Royal Marsden Hospital NHS Trust,4The Royal Marsden NHS Trust

Identifying research priorities in HPB cancer surgery: a modified Delphi process

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Samir Pathak1,Stephen Knight2,Alan Christie3,Louise Jones4,Jonathan Rees5,Ewen Harrison6,Mark Taylor7
1Bristol Royal Infirmary,2Usher Institute, University of Edinburgh,3Royal Infirmary of Edinburgh,4University Hospital Aintree,5bristol Royal Infirmary,6Usher Institure, University of Edinburgh,7Mater Hospital

Supporting the needs of people living with metastatic and secondary disease

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Georgina Smerald1,Rachel White1,Jacqueline Goodchild1
1Macmillan Cancer Support

Using Genetic Barcoding to Uncover the Evolutionary Dynamics of Drug Resistance Emergence in Colorectal Cancer.

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Freddie Whiting1,Richard Nichols2,Marc Williams1,Calum Gabutt3,Ann-Marie Baker1,Trevor Graham1
1Barts Cancer Institute,2Queen Mary University of London,3UCL

Arrayed CRISPR library screen to identify synthetic lethal partners of the histone methyltransferase KMT2D in diffuse large B cell lymphoma

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Elizabeth Blaikley1,Mark Cockerill1,Cath Eberlein1,Ben Hodgson1,Graeme Walker1,Caroline Springer1
1CRUK Manchester Institute

Evaluation of a service adopting a proactive approach to high risk of lung cancer: The Liverpool Healthy Lung Programme

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Bhagabati Ghimire1,Roberta Maroni2,Daniel Vulkan2,Zoheb Shah2,Michelle Timoney3,Lisa Jones3,Rachel Arvanitis3,Martin Ledson4,Katy Gardner4,Michael Marcus5,Sarah Hill5,Darcy Fideo5,Sabrina Mason5,Samuel G. Smith6,Linda Lukehirst4,Faye Clarke4,Samantha Quaife7,Veronique Poirier8,Karen Fitzgerald8,Stephen W. Duffy9,John K. Field10
1,2Wolfson institute of Preventive Medicine, Queen Mary University of London,3NHS Liverpool Clinical Commissioning Group,4Liverpool Heart and Chest Hospital,5Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre,6Leeds Institute of Health Sciences, University of Leeds,7Institute of Epidemiology and Health, University College London,8Accelerate, Coordinate, Evaluate (ACE) team, Cancer Research UK,9Wolfson Institute of Preventive Medicine, Queen Mary University of London,105 Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre

A Single Centre Study to Assess Outcomes and Toxicity Profiles in Patients with Non-Small Cell Lung Cancer Receiving Pembrolizumab Therapy

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Wing Kin Liu1,Stephen Robinson1,David Chao2
1North Middlesex Hospital,2Royal Free Hospital

Efficient elimination of B-lineage lymphomas using sortase A-generated site-specific anti-CD20-MMAE conjugates

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Wen-bin Zhao1,Li-qiang Pan2,Wen-hui Liu1,Shu-qing Chen1
1Zhejiang university,2Harvard Medical School

High-content Profiling in Oesophageal Adenocarcinoma for Identification and Mechanistic Characterisation of Small Molecules to Inform Preclinical Development and Patient Stratification

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Rebecca Hughes1,Richard Elliot1,Ashraff Makda1,Robert O'Neill1,Ted Hupp1,Neil Carragher1
1University of Edinburgh

Reversible inhibition of MYC translation in primary chronic lymphocytic leukaemia cells following eIF4A inhibition is associated with stabilization of MYC mRNA

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Sarah Wilmore1,Alison Yeomans1,Sophie Marriott1,Francesco Forconi1,Freda Stevenson1,Andrew Steele1,Mark Coldwell1,Graham Packham1
1University of Southampton

What is fuelling overweight and obesity and which policy actions are needed? : WCRF/ AICR Third Expert Report

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Michelle McCully1,Giota Mitrou1,Susannah Brown1,Isobel Bandurek1,Louise Meincke1,Bryony Sinclair1,Ifigeneia Bourgiezi1,Nigel Brockton2,Deirdre McGinley-Gieser2,Martin J. Wiseman1,Kate Allen1
1World Cancer Research Fund International,2American Institute for Cancer Research

The combination of curcumin and doxorubicin shows a selective cytotoxic effect on acute myeloid leukaemia cell line

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Noor Hasan1,Noor Hasan1,Helen Roberts1,Lucy Ghali1,Sandra Appiah1
1Middlesex University

Transcriptome-based identification of lovastatin as a breast cancer stem cell-targeting drug

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Marco Velasco-Velazquez1,Luz Vásquez-Bochm1,Mireya Velázquez-Paniagua1,Sandra Castro-Vázquez1,Sandra Guerrero-Rodríguez1,Abimael Mondragon-Peralta1,Mayra Pérez-Tapia2,Aliesha González-Arenas1
1National Autonomous University of Mexico,2National Polytechnic Institute

Immunohistochemical Expression of Different Sub-Types of Cytokeratins by Endometrial Stromal Sarcoma

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Iolia Akaev1,Siavash Rahimi2,Carla Marani3,Mridula Chopra1,Chit Cheng Yeoh2
1University of Portsmouth,2Portsmouth Hospitals NHS Trust,3San Carlo di Nancy Hospital

Understanding the role of γδ T cells in colorectal cancer

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Toshiyasu Suzuki1,Rachel Ridgeway1,Rene Jackstadt1,Joshua Leach1,Natalie Roberts2,Anett Jandke2,Adrian Hayday2,Owen Sansom1,Seth Coffelt1
1Cancer Research UK Beatson Institute,2Francis Crick Institute

Long non-coding RNA LINC00973 is a putative biomarker of colon cancer relapse

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Nikolai Lisitsyn1,Olga Zinovieva1,Evgenia Grineva1,Maria Prokofjeva1,Dmitry Karpov1,Andrei Zheltukhin1,George Krasnov1,Anastasiya Snezhkina1,Anna Kudryavtseva1,Peter Chumakov1,Tamara Mashkova1,Vladimir Prassolov1
1Engelhardt Institute of Molecular Biology

Piperlongumine, a novel treatment option to overcome BRAF inhibitor resistance in melanoma

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Sharavan Ramachandran1,Neel Fofaria1,Sahdeo Prasad1,Sanjay Srivastava1
1Texas Tech University Health Sciences Center

Image fusion targeted prostate biopsy in 771 men at risk: a multi-centre evaluation showing low diagnostic yield of significant cancer in non-targeted biopsies

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Saiful Miah1,Feargus Hoskings-Jervis2,David Eldred-Evans2,Taimur Shah2,Mark Laniado3,Richard Hindley3,Alan Doherty3,Andrew Sinclair3,Daniel Burke3,Jeetesh Bhardwa3,Omer Karim3,Bruce Montgomery3,Simon Bott3,Neil Barber3,Raj Nigam3,Manit Arya4,Mathias Winkler1,Clare Allen4,Hashim Ahmed2
1Imperial College NHS Healthcare,2Imperial College London,3Nuada Urology London,4University College London Hospital

Phase I multicenter, open-label study to establish the maximum tolerated dose (MTD) of trifluridine/tipiracil and oxaliplatin combination in patients (pts) with metastatic colorectal cancer (mCRC)

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Mark Saunders1,Antoine Hollebecque2,Aitana Calvo3,Thierry André4,Guilem Argiles5,Andres Cervantes6,Catherine Leger7,Aude Valette7,Nadia Amellal7,Ronan Fougeray7,Josep Tabernero5
1The Christie NHS Foundation Trust, Manchester,2Drug Development Department (DITEP: Département d'Innovations Thérapeutiques et Essais Précoces), Gustave Roussy Cancer campus, Villejuif,3Gregorio Marañon University General Hospital, Madrid,4Hôpital Saint-Antoine, service d'oncologie, 184, rue du Faubourg-Saint-Antoine, Paris,5Vall d'Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona,6Department of Medical Oncology, Biomedical Research Institute, Incliva, University of Valencia,7Institut de Recherches Internationales Servier, Suresnes

The CamGFR model for renal function in patients with cancer: Validation and extension for use with data from isotope mass dilution spectrometry creatinine assays

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Edward Williams1,Cameron Whitley1,Jamie Weaver2,Claire Connell1,Reed Stratton Geisler1,Daniel Giglio3,Simon Tavaré1,Duncan Jodrell1,Tobias Janowitz1
1Cancer Research UK Cambridge Institute, Cambridge,2Christie NHS Foundation Trust, Mancherster,3University of Gothenburg, Gothenburg