420 abstracts found.



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The incidence of non-ovarian cancers in women with elevated CA125 levels in General Practice

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Garth Funston1,Willie Hamilton2,Gary Abel2,Emma Crosbie3,Brian Rous4,Fiona Walter5

1Department of Public Health and Primary Care, University of Cambridge,2University of Exeter,3Gynaecological Oncology Research Group, Division of Cancer Sciences, University of Manchester,4National Cancer Registration and Analysis Service, Public Health England,5Department of Public Health and Primary Care, University of Cambridge, Cambridge


The predictive value of CA125 for ovarian cancer in General Practice: a population-based cohort study of over 50,000 women

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Garth Funston1,Willie Hamilton2,Gary Abel2,Emma Crosbie3,Brian Rous4,Fiona Walter1

1Department of Public Health and Primary Care, University of Cambridge,2University of Exeter,3Gynaecological Oncology Research Group, Division of Cancer Sciences, University of Manchester,4National Cancer Registration and Analysis Service, Public Health England


Interim results from the IMPACT study: evidence for PSA screening in BRCA2 mutation carriers

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Rosalind Eeles1,Elizabeth Page2,Elizabeth Bancroft3,Mark Brook1,Melissa Assel4,Judith Offman5,Zsofia Kote-Jarai1,Andrew Vickers4,Hans Lilja4,The IMPACT study Steering Committee and IMPACT study collaborators6

1The Institute of Cancer Research, London, UK,2The Institute of Cancer Research,3Royal Marsden NHS Foundation Trust, London, UK,4Memorial Sloan Kettering Cancer Center, New York, US,5King’s College London, London, UK,6the Institute of Cancer Research


Non-invasive methylation test to detect cervical pre-cancer in self-collected vaginal and urine specimens

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Belinda Nedjai1,Caroline Reuter1,Toni Hollingworth1,Janet Austin1,Louise Cadman1,Jack Cuzick1,Attila Lorincz1

1Queen Mary University of London, London, UK


Prospective clinical validation of novel serum biomarker test for the identification of patients at risk of brain tumour.

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Paul Brennan1,Holly Butler2,Mark Hegarty3,Ben Smith2,David Palmer2,Michael Jenkinson4,Matt Baker5

1university of edinburgh,2University of Strathclyde,3Clin Spex Dx Ltd,4University of Liverpool,5university of Strathclyde


Could novel inhibition of acid ceramidase with LCL521 have a translatable role for locally advanced rectal cancer?

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Rachael Clifford1,Naren Govindarajah1,David Bowden1,Paul Sutton1,Aiping Bai2,Zdzislaw Szulc2,Besim Ogretmen2,Jason Parsons1,Dale Vimalachandran3
1Institute of Cancer Medicine, The University of Liverpool,2Medical University of South Carolina,3The Countess of Chester Hospital

A mixed methods study investigating the effects of a home-based exercise programme on functional outcomes and quality of life in patients with breast cancer undergoing (neo) adjuvant chemotherapy.

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Alison Kelly1
1Queen Margaret University, Edinburgh

PARP inhibition elicits tumour cell-intrinsic immune phenotypes in DNA repair deficient cancers.

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Roman Chabanon1,Gareth Muirhead2,Dragomir Krastev2,Julien Adam1,Marlène Garrido1,Daphné Morel1,Nicolas Dorvault1,Rebecca Marlow3,Alan Ashworth4,Stephen Pettitt2,Syed Haider2,Andrew Tutt2,Aurélien Marabelle1,Jean-Charles Soria5,Christopher Lord2,Sophie Postel-Vinay1
1Gustave Roussy,2Institute of Cancer Research,3King's College London,4UCSF Helen Diller Family Comprehensive Cancer Centre,5AstraZeneca/MedImmune

ORAI2 promotes tumorigenesis and metastasis in gastric cancer via activation of the PI3K/Akt and FAK/MAPK/ERK pathways

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Shayi Wu1
1University of Hong Kong

Deciphering the molecular signalling underpinning early-dissemination and metastasis from stage I colorectal cancer

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Philip Dunne1,Maurice Loughrey2,Helen Coleman2,Aoife McCooey2,Susan Richman3,Andrew Blake4,Keara Redmond2,Dion Morton5,Ian Tomlinson5,Simon Leedham4,Rachael McBride2,Jeffrey Campbell2,Tim Maughan4,Mark Lawler2,S:cort Consortium6
1Centre for Cancer Research & Cell Biology Queen's University Belfast, Belfast, UK ,2Queen's University Belfast, Belfast, UK,3University of Leeds, Leeds, UK,4University of Oxford, Oxford, UK,5University of Birmingham, Birmingham, UK,6S:CORT Consortium, Oxford, UK

Adolescent cancer risk exposures predict intermediate cancer risk exposures at age 24 years: A longitudinal analysis using ALSPAC data

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Caroline Wright1,Richard Martin1,Rona Campbell1,Ruth Kipping1,Matthew Hickman1,Jon Heron1
1University of Bristol

Lung cancer survival in seven high-income countries 2010-2014: assessing the impact of stage at diagnosis by sex (the ICBP SURVMARK-2 project)

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Marzieh Araghi1,Miranda Fidler-Benaoudia2,Melina Arnold3,Eileen Morgan3,Mark Rutherford4,Freddie Bray3,Isabelle Soerjomataram3
1University College London,2Cancer Control Alberta,3International Agency for Research on Cancer (IARC/WHO),4University of Leicester

Identification of novel HNF1B mRNA splicing variants and their qualitative and semi-quantitative profile in selected healthy and tumor tissues

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Jan Hojny1,Nikola Hajkova1,Michaela Bartu1,Pavel Dundr1,Ivana Ticha1
1Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague

MDM2 antagonists synergize with Trametinib in well-differentiated/dedifferentiated liposarcomas.

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Shomereeta Roy1,Audrey Laroche1,Stephanie Verbeke1 Verbeke1,Antoine Italiano1
1INSTITUTE OF BERGONIE, BORDEAUX

Cancer Survivorship; Research is a long term commitment. Does current trial banding reflect this?

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Nicola Rivington1,Ann O'Callaghan1
1Portsmouth Hospitals Trust

Evaluating the impact of patient and public involvement (PPI) in the Life After Prostate Cancer Diagnosis (LAPCD) study

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Jo Brett1,Hugh Butcher2,John Keenan3,Darryl Catton2,Zoe Davey1,Fiona Matley1,Eila Watson1,Penny Wright4,Adam Glaser4,Anna Gavin5
1Oxford Brookes University,2Patient Representative,3Patietn Representative,4University of Leeds,5Queens University Belfast

Retrospective analysis of the prevalence of family history of psoriasis in patients who develop rheumatological immune-related adverse events (irAEs)

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Ionut-Gabriel Funingana1,Christine Parkinson1,Sarah Welsh1,Deniz Tafrali2,Pippa Corrie1,Anshuman Malaviya1
1Cambridge University Hospitals NHS Foundation Trust,2Medical University of Graz

Role of RTK/MAPK/ERK signaling in TGF-β and Activin mediated actions

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Srishti Gautam1
1Indian Institute of Science

Development of a proteomics-based predictor for targeted use of IAP antagonists in colorectal cancer

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Christopher McCann1
1Queen's University Belfast

Novel inherited mutations in genes that associated with breast cancer in Saudi population

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Yousef M Hawsawi1,Edward Cupler21,Abdelrazak Meliti1,Hosam Alardati1
1King Faisal Specialist Hospital and Research Centre-Jeddah

Orbital Tumor Board: lifesaver or timewaster?

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Ayesha Butt1
1Aga Khan University Hospital

Cancer comorbidities and hospital admission: A Scottish Routes from Diagnosis analysis

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Emily Moore1,Cheryl Denny2,Kelly Sheil-Davis3,Clare Le Blanc3
1Information Services Division, NHS National Services Scotland, Edinburgh, UK,2Information Services Division,3MacMillan Cancer Support

A novel ProTide, NUC-7738, induces AMPK activation and cell death in both cell lines and ex vivo tissues of human renal cell carcinoma

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Mary Kudsy1,Mustafa Elshani1,Sarah Puthur1,Wen Chen1,In Hwa Um1,Grant D. Stewart2,Maeve Rahilly3,Alex Chapman3,Michelle Myers4,David J. Harrison1
1University of St Andrews,2University of Cambridge,3Victoria Hospital, NHS Fife,4Nucana

Project Swallow: Living with oesophageal cancer

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Henry Goodfellow1,Elizabeth Murray1,Kathy Pritchard-Jones2,Chris Robson3,Muntzer Mughal4
1university college London,2UCL partners,3Living with,4UCLH

Phenotype dictates outcome in synchronously resected primary colorectal tumours and matched liver metastases

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Kathryn Pennel1,Colin Steele1,Antonia Roseweir1,Rene Jackstadt2,Colin Nixon2,Xabier Cortes-Lavaud2,Campbell Roxburgh1,Hester van Wyk1,Donald McMillan1,Paul Horgan1,Owen Sansom2,Joanne Edwards1
1University of Glasgow, Glasgow, UK,2Cancer Research UK Beatson Institute, Glasgow, UK

Investigate a potential link between sensitivity of basal subtype of  Breast Cancer BCa to RNAP1 inhibitors and the levels of activated rRNA synthesis.

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Sameerh Alsahafi1,Dr. Konstantin Panov1,Professor.ross Hannan2
1Queens University Belfast,2John Curtin School of Medical Research, ANU

Tumour Deposits as an independent prognostic factor for Colorectal Cancer

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Jinpo Xiang1,Takatoshi Matsuyama2,Yusuke Kinugasa2
1Imperial College London,2Tokyo Medical and Dental University

Development and validation of a risk prediction model for lung cancer with common health examination indexes

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Zhangyan Lyu1,Ni Li1,Fengwei Tan1,Jiang Li1,Chunqing Lin1,Hongda Chen1,Jiansong Ren1,Jufang Shi1,Kai Su1,Fang Li1,Xiaoshuang Feng1,Luopei Wei1,Xin Li1,Yan Wen1,Gang Wang2,Shuohua Chen2,Shouling Wu2,Min Dai1,Jie He1
1National Cancer Center, Beijing, China, National Clinical Research Center for Cancer, Beijing, China, Cancer Hospital, Beijing, China, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,2Kailuan General Hospital, Tangshan, China

Metabolic functions of astrocytes are retained by glioblastoma stem-like cells and support glioblastoma growth in vivo

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Tobias Ackermann1,Maria Francesca Allega2,Anaïs Oudin3,Anna Golebiewska3,Olivier Keunen3,Simone P. Niclou3,Eyal Gottlieb2,Saverio Tardito2
1Cancer Research UK Beatson Institute,2Oncometabolism Laboratory, Cancer Research UK Beatson Institute,3NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health

Exploring metastatic dormancy to tackle breast cancer metastasis

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Stefania Di Blasio1,Laurie J Gay1,Ilaria Malanchi1
1The Francis Crick Institute

Body composition and chemotherapy toxicity in women with early breast cancer: The Cando-3 study

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Ramsey Cutress1
1Faculty of Medicine, University of Southampton

3-D cell culture models for detection of biomarker indicating anti-EGFR antibody resistance in colon cancer patients

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Jens Hahne1,Andrea Lampis1,Michele Ghidini2,Margherita Ratti2,Massimiliano Salati1,Chiara Senti2,Rodolfo Passalacqua2,Luciano Cascione3,Chiara Braconi1,Owen Sansom4,Matteo Fassan5,Nicola Valeri1
1The Institute of Cancer Research London,2Istituti Ospitalieri di Cremona,3Institute of Cancer Research Belinzola,4The Beatson Institute for Cancer Research,5University of Padua

Roles of EZH2 and KDM6B during EMT

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Camille Lachat1,Amandine Etcheverry2,Marc Aubry2,Jean Mosser2,Michael Herfs3,Jean-Paul Feugeas4,Michael Boyer-Guittaut4,Paul Peixoto5,Eric Hervouet5
1INSERM UMR1098,2CHU Rennes, Service de Génétique Moléculaire et Génomique, Rennes F-35033, France ; CNRS, UMR 6290, Institut de Génétique et Développement de Rennes (IGDR), Rennes F-35043, France ; Université Rennes1, UEB, UMS 3480 Biosit, Faculté de Médecine, Rennes F-35043, France ; Plate-forme Génomique Environnementale et Humaine Biosit, Université Rennes1, Rennes F-35043, France,3Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liege, Belgium,4Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France,5Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France ; EPIGENEXP Platform, University of Bourgogne Franche-Comté, F-25000 Besançon, France

Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning

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Korsuk Sirinukunwattana1,Enric Domingo1,Susan Richman2,Keara Redmond3,Andrew Blake1,Clare Verrill1,Simon Leedham1,Katerina Chatzipli4,Claire Hardy4,Celina Whalley5,Chieh-Hsi Wu1,Andrew Beggs5,Ultan McDermott6,Philip Dunne3,Angela Meade7,Steven Walker8,Graeme Murray9,Leslie Samuel10,Matt Seymour11,Ian Tomlinson5,Philip Quirke2,Tim Maughan1,Jens Rittscher1,Viktor Koelzer12
1University of Oxford,2University of Leeds,3Queen's University Belfast,4Wellcome Sanger Institute,5University of Birmingham,6AstraZeneca,7University College London,8Almac Group Ltd,9University of Aberdeen,10NHS,11NIHR,12University of Zürich

Safety and efficacy of 12 mg/d lenvatinib (LEN) in patients with unresectable hepatocellular carcinoma (uHCC) and bodyweight >80 kg in REFLECT

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Arndt Vogel1,Masatoshi Kudo2,Ann-Lii Cheng3,Max W. Sung4,Richard S. Finn5,Albert Y. Lin6,Ghassan K. Abou-Alfa7,Angel Alsina8,Valeriy Breder9,Niall Tebbutt10,Pia Osterlund11,C. J. Yen12,Min Ren13,Soamnauth Misir13,Corina E. Dutcus13,Daniel Palmer14,Philippe Merle15,Matthias Pinter16,TR Jeffry Evans17
1Hannover Medical School,2Kindai University School of Medicine,3National Taiwan University Hospital,4Tisch Cancer Institute at Mount Sinai,5Geffen School of Medicine, UCLA Medical Center,6VA Palo Alto Health Care System,7Memorial Sloan Kettering Cancer Center,8Tampa General Hospital,9N.N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation,10Olivia Newton-John Cancer Centre,11Tampere University and Central Hospital,12National Cheng Kung University Hospital,13Eisai Inc.,14University of Liverpool, Liverpool,15CHU de Lyon -Hospital La Croix-Rousse,16Medical University of Vienna,17University of Glasgow

Patient Perspective of Experimental Cancer Medicine (PpExCaM Survey) – a Patient-led Initiative to Understand the Views of Participating in Early-Phase Trials

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Mekala Gunaratnam1,Emma Hainsworth1,Terry Emmery2,Tim Meyer1
1University College London Cancer Institute, London, UK,2Patient participant

New Strategy for the Identification of Squamous Carcinoma Antigens that Induce Therapeutic Immune Responses in Tumor-Bearing Mice

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Edward Cohen1
1The University of Illinois at Chicago

Ad5NULL-A20 – a precision virotherapy that efficiently and selectively targets αvβ6 positive cancers following intravenous administration

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Alan Parker1,James Davies1,Gareth Marlow1,Hanni Uusi-Kerttula1,Gillian Seaton1,Luke Piggott1,Richard Clarkson1,John Chester1
1Cardiff University, Cardiff, UK

Evaluation of local follow-up of long-term cancer survivors – The ADAPT Programme

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Charlotte Summerfield1,Ellie White2,Valerie Goode2,Richard Cowan2,John Radford2
1The University of Manchester,2The Christie NHS Foundation Trust

Pilot randomised trial of online self-monitoring of symptoms during pelvic radiotherapy eRAPID approach (electronic patient self-Reporting of Adverse-events: Patient Information and aDvice)

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Galina Velikova1,Patricia Holch2,Kate Absolom1,Katrina Walker1,Rose Peacock1,Simon Pini1,Susan Davidson3,Jacki Routledge3,Ann M Henry1,Kevin Franks1,Claire Hulme1,Carolyn Morris4,Lucy McParland1,Julia Brown1
1University of Leeds,2Leeds Beckett University,3The Christie Hospital Manchester,4NCRI Consumer Forum

Comprehensive evaluation of mutation spectra detected in primary cutaneous melanomas including the identification of novel loss-of-function mutants

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Nikola Hájková1
1Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague

Factor XIIIA variants ³⁴Leu and ⁶⁵⁰Ile demonstrate functional differences for ECM proteins

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Elmena Elfaki1,Aruna Asipu1,Timothy J. Perren2,Alexander F. Markham1,Rashida Anwar1
1University of Leeds,2University of Leeds / Leeds Teaching Hospitals Trust

EXACT: A multicomponent, feasibility, exercise trial for men with metastatic castrate-resistant prostate cancer.

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Gillian Prue1,Malcolm Brown1,Marie Murphy2,Helen McAneney1,Joe O'Sullivan1,Suneil Jain1
1Queen's University Belfast,2Ulster University

High plasmatic IL-8 and low nitrites levels are independent predictors of poor prognosis in nasopharyngeal carcinoma patients

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Ahmed Amine Zergoun1,Taha Merghoub2,Chafia Touil-Boukoffa3,Mehdi Bourouba3
1University of M'hamed Bougara, Boumerdes,2MSKCC,3USTHB

Barriers and opportunities to cancer research in Wales: health professionals’ perspective

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Ishrat Islam1,Eleanor Webber2,Rachel Savery2,Annmarie Nelson1,Ian Lewis1,Anthony Byrne1
1Cardiff University,2Wales Cancer Research Centre

Smoking status before and after colorectal cancer diagnosis and mortality in Korean men

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Doeun Jang1,Sunho Choe1,Ji Won Park1,Seung-Yong Jeong1,Aesun Shin1
1Seoul National University College of Medicine

Sulforaphane induces pyroptotic cell death via caspase signaling pathway in Hepatocellular Carcinoma (HCC): an alternative immuno-therapeutic approach

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Kanipandian Nagarajan1,Deyu Li2,Dongxiao Li3
1Henan Provincial People’s Hospital/Henan University, Zhengzhou, China,2Henan Provincial People's Hospital, Zhengzhou, China,3Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

“I felt that I had some people who cared about me.” The impact of real-time remote patient monitoring on clinical practice: experiences of patients and clinicians participating in the eSMART study

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Lisa McCann1,Liane Lewis1,Olubukola Oduntan1,Morven Miller1,Grigorios Kotronoulas2,Eileen Furlong3,Patricia Fox3,Andrew Darley3,Alison Buick3,Aidrian Flowerday4,Emma Ream5,Jo Armes5,Elizabeth Patiraki6,Stylianos Katsaragakis6,Alexander Gaiger7,Geir Berg8,Paul McCrone9,Christine Miaskowski10,Peter Donnan11,Roma Maguire1
1University of Strathclyde,2University of Glasgow,3University College Dublin,4Docobo,5University of Surrey,6University of Athens,7Medical University Vienna,8Sykehuset-Innlandet Hospital Trust,9King's College London,10University of california,11University of Dundee

Novel indoline derivatives induce cell death and cell cycle arrest via the deregulation of oncogenic target genes

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Kumar Subramanian1,Jeyalakshmi Kandhavelu1,Aliyu Musa2,Hande Yapislar3,Meenakshisundaram Kandhavelu2,Paul Ruff1,Clement Penny1
1University of the Witwatersrand,2BioMediTech, Tampere University and Tays Cancer Center,3Acibadem University

Assessment of the effect of oncolytic virotherapy in combination with cavitational ultrasound in the treatment of colorectal liver metastases using a precision cut tumour slice model

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Marcos Kostalas1,Joshua Owen2,Claudia Hill2,Christopher Smith3,Nicola Annels3,Robert Carlisle2,Hardev Pandha3
1Royal Surrey County Hospital, Guildford, UK,2University of Oxford, Oxford, UK,3University of Surrey, Guildford, UK