420 abstracts found.



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Pilot randomised trial of online self-monitoring of symptoms during pelvic radiotherapy eRAPID approach (electronic patient self-Reporting of Adverse-events: Patient Information and aDvice)

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Galina Velikova1,Patricia Holch2,Kate Absolom1,Katrina Walker1,Rose Peacock1,Simon Pini1,Susan Davidson3,Jacki Routledge3,Ann M Henry1,Kevin Franks1,Claire Hulme1,Carolyn Morris4,Lucy McParland1,Julia Brown1
1University of Leeds,2Leeds Beckett University,3The Christie Hospital Manchester,4NCRI Consumer Forum

Comprehensive evaluation of mutation spectra detected in primary cutaneous melanomas including the identification of novel loss-of-function mutants

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Nikola Hájková1
1Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague

Factor XIIIA variants ³⁴Leu and ⁶⁵⁰Ile demonstrate functional differences for ECM proteins

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Elmena Elfaki1,Aruna Asipu1,Timothy J. Perren2,Alexander F. Markham1,Rashida Anwar1
1University of Leeds,2University of Leeds / Leeds Teaching Hospitals Trust

EXACT: A multicomponent, feasibility, exercise trial for men with metastatic castrate-resistant prostate cancer.

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Gillian Prue1,Malcolm Brown1,Marie Murphy2,Helen McAneney1,Joe O'Sullivan1,Suneil Jain1
1Queen's University Belfast,2Ulster University

High plasmatic IL-8 and low nitrites levels are independent predictors of poor prognosis in nasopharyngeal carcinoma patients

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Ahmed Amine Zergoun1,Taha Merghoub2,Chafia Touil-Boukoffa3,Mehdi Bourouba3
1University of M'hamed Bougara, Boumerdes,2MSKCC,3USTHB

Barriers and opportunities to cancer research in Wales: health professionals’ perspective

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Ishrat Islam1,Eleanor Webber2,Rachel Savery2,Annmarie Nelson1,Ian Lewis1,Anthony Byrne1
1Cardiff University,2Wales Cancer Research Centre

Smoking status before and after colorectal cancer diagnosis and mortality in Korean men

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Doeun Jang1,Sunho Choe1,Ji Won Park1,Seung-Yong Jeong1,Aesun Shin1
1Seoul National University College of Medicine

Estimating the gap in the provision of specialist cancer nurses in England

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Rachel White1,Jacqueline Goodchild1
1Macmillan Cancer Support

Friendship in the stable phase of cancer

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Hilde Buiting1,Michelle van Eijk2,Daniel de Vries3
1Netherlands Cancer Institute,2University of Amsterdam / Netherlands Cancer Institute,3university of Amsterdam

Microgel Matrices for Human Cancer Organoid Production

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Jessica Pinheiro de Lucena-Thomas1,Kim Luetchford2,Marianne Ellis2,Paul De Bank1
1University of Bath,2Cellesce Ltd

Hormone-related diseases and prostate cancer: an English national record linkage study

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Eleanor Watts1,Timothy Key1,Ruth Travis1,Aurora Perez-Cornago1,Raphael Goldacre1,Naomi Allen1
1University of Oxford, Oxford, UK

Understanding international variation in access to PET-CT for oncology diagnostics: An International Cancer Benchmarking Partnership (ICBP) study.

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Charlotte Lynch1,Irene Reguilon2,Deanna Langer3,Damon Lane4,Wai-Lup Wong5,Fergus McKiddie6,Andrew Ross7,Lorraine Shack8,Thida Win5,Christopher Marshall9,Mona-Elizabeth Revheim10,Bolette Danckert11,Sabina Dizdarevic5,Canice McGivern12,Anne Hazlett12,Cheryl Louzado13,Mark MacMillan8,Sam Harrison1
1Cancer Research UK, London, UK,2eConsult, London, UK,3Cancer Care Ontario, London, UK,4Pacific Radiology, New Zealand,5NHS England, London, UK,6NHS Grampian, Aberdeen, UK,7Canadian Association of Nuclear Medicine, Ottawa, Canada,8Alberta Health Services, Edmonton, Canada,9Wales Research and Diagnostic PETIC, Cardiff, UK,10Oslo University Hospital, Oslo, Norway,11Aarhus University, Aarhus, Denmark,12Belfast Health and Social Care Trust, Belfast, UK,13Canadian Partnership Against Cancer, Toronto, Canada

Delivery of radiotherapy clinical trials: Recommendations for best practice across Clinical Trial Units (CTU) and the National Radiotherapy Trials Quality Assurance Group (RTTQA)

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Lisette Nixon1,Elizabeth Miles2,Natalie Abbott3,Sue Bell4,Clare Cruickshank5,Patty Diez6,Alexandra Smith4,Yat Tsang6,Emma Hall5,on behalf of CTRad7
1Cardiff University, Cardiff, UK,2Coordinator National Radiotherapy Trials QA (RTTQA) Group, London, UK, Mount Vernon Cancer Centre, Northwood, UK,3Velindre Cancer Centre, Cardiff, UK,4University of Leeds, Leeds, UK,5The Institute of Cancer Research, London, UK,6Mount Vernon Cancer Centre, Northwood, UK,7National Cancer Research Institute, London, UK

Antiproliferation and anti-invasion of 1’-Acetoxychavicol acetate on hormonal-resistant breast cancer cells

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Nalinee Pradubyat1,Wannarasmi Ketchart2,Carlo Palmieri3,Athina Giannoudis4
1University of Liverpool,2Faculty of Medicine, Chulalongkorn University,3Institute of Translational Medicine, University of Liverpool, Clatterbridge Cancer Centre, UK,4Institute of Translational Medicine, University of Liverpool

An Analysis of Prognostic Biomarkers of the Systemic Inflammatory Response in Cancers of Unknown Primary

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Rebekah Patton1,Rebekah Patton1,Gillian Knowles1,Rachel Haigh1,Lucy Dobbs2,Barry Laird1,Colin Barrie1,Sally Clive1
1NHS Lothian, Edinburgh, UK,2University of Edinburgh, Edinburgh, UK

Next generation Cytogenetics: Comprehensive Structural Analysis of Cancer Genomes by Optical Genome Mapping

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Ernest Lam1,Andy Peng2,Alex Hastie1,Yannick Delpu1
1Bionano Genomics,2Bionano Genomcis

Proteomic Profiling on apoptotic effect of keto-boswellic acid

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Fahad AL Zadjali1,Asma Bani Oraba1
1Sultan Qaboos University

Cancer Quality of Life Metric Project – Lessons learned from an implementation pilot

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Alice Simon1,Sarah Gelcich2,Adam Glaser3,Andria Hanbury4,Luke Hounsome5,Jane Maher6,Erik Mayer7,Alison Richardson8,Simon Rogers9,Lesley Smith10,Galina Velikova2,and the NHS England Cancer Quality of Life Working and Steering Groups10
1NHS England, London UK,2University of Leeds, Leeds, UK,3University of Leeds,4York Health Economics Consortium, York, UK,5Public Health England,6Macmillan Cancer Support, London UK, Mount Vernon Cancer Centre, Northwood, UK,7Imperial College Healthcare NHS Trust, London, UK, The Royal Marsden NHS Foundation Trust, London, UK,8University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK,9Aintree University Hospital NHS Foundation Trust, Liverpool, UK,10NHS England, London, UK

ADSCaN: A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-Small Cell Lung Cancer (NSCLC)

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Claire Lawless1,Kathleen Boyd2,Corinne Faivre-Finn3,John Fenwick4,Tom Haswell5,David Landau6,Jason Lester7,Joe Maguire8,Elaine McCartney1,Jim Paul1,Matthew Hatton9

1CRUK Clinical Trials Unit, Beatson West of Scotland Cancer Centre, Glasgow, UK,2Health Economics & Health Technology Assessment, University of Glasgow, Glasgow, UK,3The Christie NHS Foundation Trust, Manchester, UK,4Gray Institute of Radiation Oncology & Biology, University of Oxford, Oxford, UK,5West of Scotland Cancer Research Consumer Panel, Glasgow, UK,6Guys & St Thomas NHS Trust, London, UK,7Velindre Cancer Centre, Cardiff, UK,8Clatterbridge Cancer Centre, Liverpool, UK,9Weston Park Hospital, Sheffield, UK


Palliative radiotherapy to the oesophagus: Less is just as good.

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Shefali Parikh1,Oliver Coen1,Rebecca Goody1,Ganesh Radhakrishna2,Paul Hatfield1,Mohan Hingorani1
1Leeds Cancer Centre,2The Christie, Manchester

Predictive risk factors of venousthromboembolism (VTE) associated withperipherally inserted central catheters(PICC) in ambulant solid cancer patients:retrospective single Centre cohort study

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Osamah al-asadi1
1nhs

Defining the role of AP-1 in molecular adaptation to hypoxia in colorectal cancer

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Eric VANCAUWENBERGHE1,Hannah Bolland2,Christopher Carroll2,Leonardo Da Motta2,Anna Grabowska3,Francesca Buffa4,Adrian Harris5,Alan McIntyre2
1Hypoxia and Tumour Microenvironment Group, Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,2Hypoxia and Tumour Microenvironment Group, Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,3Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, UK,4Computational Biology and Integrative Genomics, Department of Oncology, University of Oxford, Oxford, UK,5Molecular Oncology Laboratories, Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

Carbonic Anhydrase 9 Confers Resistance to Ferroptosis/Apoptosis in Malignant Mesothelioma Under Hypoxia

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Zan Li1,Li Jiang1,Shinya Toyokuni1
1Nagoya University Graduate School of Medicine

Factors associated with Emergency Admissions for Cancer Patients in Last year of life in a UK region

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Victoria Cairnduff1,Laura Dwyer1,Colin Fox1,Gregory Fallica2,Kelly Shiell-Davis3,Anna Gavin1
1Northern Ireland Cancer Registry, Belfast, UK,2Macmillan Cancer Support,3Macmillan Cancer Support, London, UK

RAMPART Renal Adjuvant MultiPle Arm Randomised Trial

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James Larkin1,Angela Meade2,Tom Powles3,Grant Stewart4,Bhavna Oza2,Laurence Albiges5,Axel Bex6,Hanna Bryant2,Toni Choueiri7,Ian Davis8,Tim Eisen9,Alison Fielding10,Elena Frangou2,Patrick Hanlon10,David Harrison11,Rick Kaplan2,Salena Mulhere10,Paul Nathan12,Brian Rini13,Alastair Ritchie2,Clare Shakeshaft2,Ben Smith2,Martin Stockler14,Max Parmar15
1Royal Marsden Hospital,2MRC CTU at UCL,3St Bartholomew’s Hospital,4University of Cambridge,5Institut Gustave Roussy,6Royal Free Hospital,7Dana-Farber Cancer Institute,8Monash University Eastern Health Clinical School and ANZUP Cancer Trials Group,9AstraZeneca and University of Cambridge,10Patient representative,11University of St Andrews,12Mount Vernon Cancer Centre,13Cleveland Clinic,14University of Sydney,15MCR CTU at UCL

Cell culture under perfusion conditions reduces cellular metabolic stress and mimics the in vivo physiological environment in pancreatic cancer

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Daniel Hughes1,Frances Willenbrock2,Zahir Soonawalla3,Srikanth Reddy3,Michael Silva3,Somnath Mukherjee3,Eric O'Neill2
1University of Oxford, Oxford, UK,2Department of Oncology, University of Oxford, Oxford, UK,3Oxford University Hospitals, Oxford, UK

Participant views of taking part in a tailored cancer awareness intervention: Preliminary participant interview findings from the Awareness and Beliefs About Cancer Trial (ABACus3)

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Harriet Quinn-Scoggins1,Yvonne Moriarty2,Fiona Wood1,Julia Townson2,Kate Brain1
1Division of Population Medicine, School of Medicine, Cardiff University,2Centre for Trials Research, Cardiff University

Infrared imaging to predict oral cancer development in oral epithelial dysplasia

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Barnaby Ellis1,Conor Whitley1,James Ingham1,Steve Barrett1,Peter Gardner2,Richard Shaw1,Peter Weightman1,Janet Risk1
1University of Liverpool,2University of Manchester

Making 3D possible: large scale organoid expansion using bioprocess design

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Victoria Marsh Durban1,Mairian Thomas1,Kim Luetchford1,Trevor Dale1,Marianne Ellis1
1Cellesce Ltd

Curcumin as an agent for cancer prevention in colorectal cancer

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Sam Khan1,Ankur Karmokar1,Zahirah Sidat2,Nalini Foreman1,David Moore3,Anne Thomas1,Karen Brown1
1Leicester Cancer Research Centre, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester,2Hope Clinical Trials Facility, Leicester Royal Infirmary, Leicester,3University College London Hospitals NHS Foundation Trust, London

A biobank analysis of outcomes in patients with malignancy of undefined primary origin

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Mark Stares1,Rebekah Patton1,Gillian Knowles1,Rachel Haigh1,Colin Barrie1,Lucy Dobbs2,Barry Laird2,Sally Clive1
1NHS Lothian,2Edinburgh University

Development of a medium-throughput colony formation screen for identification of novel radiosensitising drugs for glioblastoma

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Natividad Gomez-Roman1,Mark R Jackson1,Sandeep Chahal1,Anthony J Chalmers1
1University of Glasgow

Delineating how PIK3CA mutation and PTEN deletion contribute to prostate cancer

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Manisha Dass1,Helen Pearson1,Matthew Smalley1,Richard Clarkson1,Wayne Phillips2,Jason Li2
1European Cancer Stem Cell Research Insititute, Cardiff University,2Peter MacCallum Cancer Centre, Melbourne

Effect of lipids on IGF axis and subsequent breast cancer risk: observational and causal estimates from independent sources

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Vanessa Tan1,Caroline Bull1,Nicholas Timpson1
1University of Bristol

Combining tyrosine kinase inhibitors with novel thiosemicarbazone iron chletors in cell lines derived from pediatric solid tumors of neurogenic origin

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Maria Krchniakova1,Jakub Neradil1,Silvia Chovanova1,Petr Chlapek1,Des. R. Richardson2,Jaroslav Sterba3,Renata Veselska1
1Masaryk University,2University of Sydney,3University Hospital Brno

Developing a digital health intervention to support young adults with cancer: The e-Prehabilitation Study

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Lisa McCann1,Kathryn McMillan1,Chris Hewitt2
1University of Strathclyde,2NHS Lothi

Developing novel platforms for delivery and investigation of vascular-targeted photodynamic therapy (VTP) of pre-clinical models of cancer; towards multi-modality prostate cancer therapy.

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Richard Bryant1,Hanna Sjoberg1,Yiannis Philippou1,Iain Tullis1,Danny Allen1,Veerle Kersemans1,Emma Murphy1,Sheena Wallington1,Paul Kinchesh1,Stuart Gilchrist1,Gillies McKenna1,Ian Mills1,Tamar Yechezkel2,Dina Preise2,Lilach Agemy2,Sean Smart1,Boris Vojnovic1,Avigdor Scherz2,Freddie Hamdy1,Ruth Muschel1
1University of Oxford,2The Weizmann Institute of Science

Reduction of full-length transglutaminase 2 (TG2-L) expression decreases cisplatin chemoresistance in an MCF-7 model of hormone-positive breast cancer

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Peter Coussons1,Ebidor Lawani-Luwaji1,Claire Pike1
1Anglia Ruskin University

Overcoming sorafenib resistance in hepatocellular carcinoma by fasting

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Jelena Krstic1,Isabel Reinisch1,Maria Depaoli1,Natascha Berger2,Christoph Noessing3,Markus Galhuber1,Ines Anders4,Martina Auer1,Elisabeth Moyschewitz1,Beate Rinner5,Martin Pichler6,Roland Malli1,Andreas Prokesch1
1Medical University of Graz, Graz, Austria, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Graz, Austria,2Department of Obstretics and Gynaecology, Medical University of Graz, Graz, Austria,3Cancer Research UK Beatson Institute, London, UK,4Medical University of Graz, Graz, Austria, Core Facility Alternative Biomodels and Preclinical Imaging, Graz, Austria,5Division of Biomedical Research, Medical University of Graz, Graz, Austria,6Division of Oncology, Medical University of Graz, Graz, Austria

Modulation of tumor microenvironment by targeting cancer associated fibroblasts in dendritic cell based immunotherapy

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Sheefa Mirza1,Clement Penny1,Nayan Jain2,Rakesh Rawal2
1University of Witwatersrand,2Gujarat University

The association between palliative healthcare service provision and place of death: a population study of cancer patients

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Maria Kelly1,Katie O' Brien1,Ailish Hannigan2
1National Cancer Registry Ireland,2University of Limerick

Digital questionnaires to help determine a face-to-face review for ‘on treatment’ oncology clinics

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Mayuran Sivanandan1,Catherine Sharma1,Pippa Bullard1,Judith Christian1
1Nottingham University Hospitals NHS Trust

Best supportive care (BSC) with or without low-dose chemotherapy (chemo) in frail elderly patients with advanced gastroesophageal cancer (aGOAC): The uncertain randomization of the GO2 phase III trial

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Daniel Swinson1,Peter Hall2,Mohan Hingorani3,Zuzani Stokes4,Jo Dent5,Kamalnayan Guptal6,Anirban Chatterjee7,Konstantinos Kamposioras8,Simon Aird Grumett9,Mohammad Khan10,Helen Marshall11,Ruddock Sharon11,Cairns David11,Christine Allmark12,Eszter Katona11,Helen C Howard11,Galina Velikova13,Simon Lord14,Matthew T Seymour15
1St James's University Hospital, Leeds, UK,2University of Edinburgh, Edinburgh.,3St James's University Hospital, Leeds.,4Lincolnshire Hospitals, Lincoln,5Calderdale and Huddersfield Royal Infirmary,6Worcester, United Kingdom,7Shrewsbury & Telford Hospitals, Shrewsbury,8Christie Hospital, Manchester,9Royal Wolverhampton Hospitals, Wolverhampton,10Scarborough Hospital, Scarborough,11CTRU, University of Leeds, Leeds,12NCRI Consumer Forum, London,13University of Leeds, Leeds,14University of Oxford, Oxford,15National Institute for Health Research Clinical Research Network, Leeds, United Kingdom

“I thought there would have been pain” A qualitative investigation of patients’ experiences of the route to, and diagnosis of, head and neck cancer.

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Jennifer Deane1,Joanne Patterson1,Linda Sharp1
1Newcastle University

Meat intake and cancer risk: prospective analyses in UK Biobank

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Anika Knuppel1,Keren Papier1,Georgina K. Fensom1,Paul N. Appleby1,Julie A. Schmidt1,Tammy Y. N. Tong1,Ruth C. Travis1,Timothy J. Key1,Aurora Perez-Cornago1
1Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford

Making Big Data available: Informatics Infrastructure supporting the MRC/CRUK funded Stratification in COloRecTal Cancer (S-CORT) programme

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Andrew Blake1,Enric Domingo1,Michael Youdell1,Susan Richman2,Peter Stewart3,Celina Whalley4,Clare Hardy5,Katerina Chatazipli5,on behalf of S-CORT Consortium6,Tim Maughan1
1University of Oxford,2University of Leeds,3Queens University Belfast,4University of Birmingham,5Wellcome Trust Sanger Institute,6S-CORT Consortium

Mutation analysis of Beta2-Microglobulin identifies a subset of deficient mismatch repair (dMMR) colorectal cancers which are protected from disease recurrence.

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Susan Richman1,Paul Barrow2,Andrew Wallace3,Kelly Handley4,Gordon Hutchins5,David Kerr6,Laura Magill4,Gareth Evans3,Richard Gray6,Phil Quirke5,James Hill2
1Leeds Teaching Hospitals NHS Trust,2Manchester Royal Infirmary,3Central Manchester University Hospitals NHS Trust,4University of Birmingham,5University of Leeds,6University of Oxford

Can people living with and beyond colorectal cancer make lifestyle changes with the support of health technology?

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Victoria Aubrey1,Clare Shaw2
1The Royal Marsden NHS Foundation Trust,2Biomedical Research Centre at The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London and Sutton

Phenotyping neutrophil subpopulations in advanced lung cancer

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Robert Grecian1,Patricia Dos Santos Coelho1,Emily Watts1,Kev Dhaliwal1,Adam Byron1,Margaret Frame1,Moira Whyte1,Sarah Walmsley1
1Edinburgh University

Inhibiting Ehmt2 and Ezh2 histone methyltransferases alters the immune microenvironment in a Trp53-/- murine ovarian cancer model

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Pavlina Spiliopoulou1,Sarah Spear2,Patricia Roxburgh3,Susanne Dowson4,Susan Mason4,Karen Blyth4,Matthew Fuchter2,Bob Brown2,Iain A McNeish2
1Beatson West of Scotland Cancer Centre, Glasgow, UK,2Imperial College London, London, UK,3Beatson West of Scotland Cancer Centre,4University of Glasgow, Glasgow, UK