420 abstracts found.



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Combining tyrosine kinase inhibitors with novel thiosemicarbazone iron chletors in cell lines derived from pediatric solid tumors of neurogenic origin

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Maria Krchniakova1,Jakub Neradil1,Silvia Chovanova1,Petr Chlapek1,Des. R. Richardson2,Jaroslav Sterba3,Renata Veselska1
1Masaryk University,2University of Sydney,3University Hospital Brno

Developing a digital health intervention to support young adults with cancer: The e-Prehabilitation Study

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Lisa McCann1,Kathryn McMillan1,Chris Hewitt2
1University of Strathclyde,2NHS Lothi

Developing novel platforms for delivery and investigation of vascular-targeted photodynamic therapy (VTP) of pre-clinical models of cancer; towards multi-modality prostate cancer therapy.

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Richard Bryant1,Hanna Sjoberg1,Yiannis Philippou1,Iain Tullis1,Danny Allen1,Veerle Kersemans1,Emma Murphy1,Sheena Wallington1,Paul Kinchesh1,Stuart Gilchrist1,Gillies McKenna1,Ian Mills1,Tamar Yechezkel2,Dina Preise2,Lilach Agemy2,Sean Smart1,Boris Vojnovic1,Avigdor Scherz2,Freddie Hamdy1,Ruth Muschel1
1University of Oxford,2The Weizmann Institute of Science

Reduction of full-length transglutaminase 2 (TG2-L) expression decreases cisplatin chemoresistance in an MCF-7 model of hormone-positive breast cancer

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Peter Coussons1,Ebidor Lawani-Luwaji1,Claire Pike1
1Anglia Ruskin University

Overcoming sorafenib resistance in hepatocellular carcinoma by fasting

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Jelena Krstic1,Isabel Reinisch1,Maria Depaoli1,Natascha Berger2,Christoph Noessing3,Markus Galhuber1,Ines Anders4,Martina Auer1,Elisabeth Moyschewitz1,Beate Rinner5,Martin Pichler6,Roland Malli1,Andreas Prokesch1
1Medical University of Graz, Graz, Austria, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Graz, Austria,2Department of Obstretics and Gynaecology, Medical University of Graz, Graz, Austria,3Cancer Research UK Beatson Institute, London, UK,4Medical University of Graz, Graz, Austria, Core Facility Alternative Biomodels and Preclinical Imaging, Graz, Austria,5Division of Biomedical Research, Medical University of Graz, Graz, Austria,6Division of Oncology, Medical University of Graz, Graz, Austria

Modulation of tumor microenvironment by targeting cancer associated fibroblasts in dendritic cell based immunotherapy

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Sheefa Mirza1,Clement Penny1,Nayan Jain2,Rakesh Rawal2
1University of Witwatersrand,2Gujarat University

The association between palliative healthcare service provision and place of death: a population study of cancer patients

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Maria Kelly1,Katie O' Brien1,Ailish Hannigan2
1National Cancer Registry Ireland,2University of Limerick

Digital questionnaires to help determine a face-to-face review for ‘on treatment’ oncology clinics

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Mayuran Sivanandan1,Catherine Sharma1,Pippa Bullard1,Judith Christian1
1Nottingham University Hospitals NHS Trust

Best supportive care (BSC) with or without low-dose chemotherapy (chemo) in frail elderly patients with advanced gastroesophageal cancer (aGOAC): The uncertain randomization of the GO2 phase III trial

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Daniel Swinson1,Peter Hall2,Mohan Hingorani3,Zuzani Stokes4,Jo Dent5,Kamalnayan Guptal6,Anirban Chatterjee7,Konstantinos Kamposioras8,Simon Aird Grumett9,Mohammad Khan10,Helen Marshall11,Ruddock Sharon11,Cairns David11,Christine Allmark12,Eszter Katona11,Helen C Howard11,Galina Velikova13,Simon Lord14,Matthew T Seymour15
1St James's University Hospital, Leeds, UK,2University of Edinburgh, Edinburgh.,3St James's University Hospital, Leeds.,4Lincolnshire Hospitals, Lincoln,5Calderdale and Huddersfield Royal Infirmary,6Worcester, United Kingdom,7Shrewsbury & Telford Hospitals, Shrewsbury,8Christie Hospital, Manchester,9Royal Wolverhampton Hospitals, Wolverhampton,10Scarborough Hospital, Scarborough,11CTRU, University of Leeds, Leeds,12NCRI Consumer Forum, London,13University of Leeds, Leeds,14University of Oxford, Oxford,15National Institute for Health Research Clinical Research Network, Leeds, United Kingdom

“I thought there would have been pain” A qualitative investigation of patients’ experiences of the route to, and diagnosis of, head and neck cancer.

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Jennifer Deane1,Joanne Patterson1,Linda Sharp1
1Newcastle University

Meat intake and cancer risk: prospective analyses in UK Biobank

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Anika Knuppel1,Keren Papier1,Georgina K. Fensom1,Paul N. Appleby1,Julie A. Schmidt1,Tammy Y. N. Tong1,Ruth C. Travis1,Timothy J. Key1,Aurora Perez-Cornago1
1Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford

CEBOC: Evaluation of the safety of Cediranib in the prevention of Bowel perforation in platinum-resistant Ovarian Cancer

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Ann White1,Andrew Clamp2,Robert Morgan2,Dilly Goonetilleke3,Angela Casbard4,Tracie-Ann Madden4,Jennifer Swettenham4,Alkesh Patel2,Charlotte Wilhelm-Benartzi4,Catherine Rogers2,Gordon Jayson2
1,2The Christie NHS Foundation Trust,3The University of Manchester,4Cardiff University

What accessible interventions are available to support cancer survivors to improve their quality of life?

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Nikki Hayward1,Sally Markwell2
1Oxford University Hospitals NHS Trust, Oxford, UK,2Oxford Brookes university

Collaboratively assessing the impact of patient and public involvement in research

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Sarah Stapleton1,Martin Lee2
1Royal Marsden Hospital and Institute of Cancer Research,2Royal Marsden and Institute of Cancer Research

Applicability of routine targeted next generation sequencing to estimate tumour mutational burden (TMB) in patients treated with immune-checkpoint inhibitor therapy

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Heather Urus1,David Pinato2,Thomas Newsom- Davis3,Persephone Du Parcq4,Katherine Belessiotis2,Leah Mapara2,Nandita Gupta5,Danielle Power2,Justin Weir5,Ching N Wong1,Ragu P Ratnakumaran2,Jamshid Khorashad4,Kathy Dominy4,Mark Bower3
1Department of Surgery & Cancer, Imperial College London,2Department of Oncology, Imperial College NHS Trust,3Department of Oncology, Chelsea & Westminster Hospital,4Molecular Pathology Laboratory, Hammersmith Hospital,5Department of Histopathology, Imperial College NHS Trust

Assessing the immunomodulatory activity of cancer prevention agents using an ex vivo tumour explant model

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Sam Khan1,Ankur Karmokar1,Zahirah Sidat2,Nalini Foreman1,David Moore3,Anne Thomas1,Karen Brown1
1Leicester Cancer Research Centre, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester,2Hope Clinical Trials Facility, Leicester Royal Infirmary, Leicester,3University College London Hospitals NHS Foundation Trust, London

Loss of BCL-3 expression increases sensitivity to irradiation induced DNA damage in colorectal cancer cells

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Christopher Parker1,Adam Chambers1,Ann Williams1
1University of Bristol, Bristol, UK

Cancer Antigen Presentation in Colorectal Cancer Local Metastases

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Thomas Starkey1,Thomas Starkey1,Tessa Sanberg2,Roland Arnold1,Ian Tomlinson1,Lennard Lee1
1University of Birmingham,2Universiteit Leiden

A screen for epigenetic reprogramming reveals LSD1 inhibitor as a potential intervention to promote differentiation in pancreatic cancer

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Frances Willenbrock1,James Wantling1,Eric O'Neill1
1University of Oxford, Oxford, UK

Understanding challenges to palliative care engagement within the early phase trials setting

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Mary Lomas1,Sandie Wellman1
1Oxford University Department of Oncology

Timeliness of treatment in rectal cancer and survival: A population-based study using a mediation approach

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Rosie Dew1,Jonathan Pratschke2,Lousie Hayes1,Linda Sharp1
1Newcastle University,2University of Naples "Federico II"

Verification of a Cartridge-based Microsatellite Instability (MSI) Platform and Cross-platform Assessment of Cases with Rare Germline Polymorphic Markers

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Gareth Gerrard1,Diana Pelka2,Nicole Gurunlian1,Georgina Briggs1,Jack Grant1,Kevin Balibi1,Phil Bennett1
1Sarah Cannon Molecular Diagnostics,2HCA Healthcare UK

Apoptotic pancreatic cancer cells induce apoptosis in mesenchymal stromal cells

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Ester Pfeifer1,Debashis Sarker1,Joy Burchell1,Francesco Dazzi1
1King's College London

Improving Outcomes For Immunotherapy-Induced Endocrinopathies in Metastatic Melanoma

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Christina Peters1,Carolyn Tang1,Joyce Ntata1,Yvette Moore1,Ankit Rao1,Poulam Patel1
1Nottingham University Hospitals NHS Trust

Strategic system change to increase patient access to research

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Maria Maguire1,Sheena Khanduri2
1The Clatterbridge Cancer Centre NHS Foundation Trust,2The Clatterbridge Cancer Centre NHS Foundation Trust

Changing patterns in internet use in women with breast cancer. A 15 year analysis in a UK cancer centre

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Richard Simcock1,Leroy Okonta1
1Sussex Cancer Centre

Using linked English cancer registration data to assess variation in diagnostic pathway length

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Clare Pearson1,Jess Fraser1,Sara Hiom1,Jon Shelton1,Jodie Moffat1
1Cancer Research UK

Novel mechanisms of overcoming apoptotic resistance in Pancreatic Cancer

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Julie Nicoll1,Daniel Longley1,Chris Scott1
1CCRCB, Queen's University Belfast

Genomic Profiling of Saudi patients with Colorectal Cancer using Next Generation Sequencing

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Saleh Alghamdi1,Alhanouf Alomani2,Bader Almuzaini2,Abdullah Alsharm1,Fida Aljaser3
1KFMC,2KAIMRC,3KSU

FOxTROT: an international randomised controlled trial in 1052 patients evaluating neoadjuvant chemotherapy for colon cancer

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Dion Morton, on behalf of the FOxTROT investigators1
1University of Birmingham, Birmingham, UK

Nr4a1-loss causes an acceleration of Myc-driven lymphomagenesis and an induction of gene of the B7-CD28

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Alexander Deutsch1,Katrin Pansy1,Christine Beham-Schmid1,Andreas Prokesch1,Julia Feichtinger1
1Medical University of Graz, Graz, Austria

Inhibition of prostate cancer cell growth, motility and ability to alter monocyte/macrophage lineage commitment by a novel TRAF6 inhibitor

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Denise Giovana Carrasco Gonzalez1,Ryan T. Bishop2,Antonio Maurizi3,Silvia Marino4,Anna Sparatore5,Mattia Capulli3,Aymen I. Idris1
1University of Sheffield,2Moffitt Cancer Centre,3University of L’Aquila,4Indiana University,5University of Milano

Serum hormones and prostate cancer incidence and mortality in UK Biobank

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Ruth Travis1,Eleanor Watts1,Georgina Fensom1,Aurora Perez-Cornago1,Anika Knuppel1,Naomi Allen1,Marc Gunter2,Richard Martin3,Karl Smith Byrne2,Neil Murphy2,Kostas Tsilidis4,Tim Key1
1University of Oxford,2International Agency for Research on Cancer,3University of Bristol,4University of Ioannina

Integrating Germline and Somatic Genetic Test Result Data into the English National Cancer Registration and Analysis Service

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Fiona McRonald1,Brian Shand1,Sophia Richardson1,Katrina Lavelle1,Sally Vernon1,Caroline Brook1,Francesco Santaniello1,Joanna Pethick1,Margreet Luchtenborg1,Steven Hardy1,Jem Rashbass1
1National Disease Registration, Public Health England, London, UK

Dietary changes and nutritional support after a pelvic cancer diagnosis: a cross-sectional study.

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Georgios Saltaouras1,Helen Lightowler2,Shelly Coe2,Amanda Horne3,Sara Matthews3,Loryn Caulfield3,Eila Watson4
1Oxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes University,2Department of Sport, Health Sciences and Social Work, Oxford Brookes University, Oxford, UK,3Department of Oncology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK,4Oxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes University, Oxford, UK

Exposure to ionizing radiation elicits significant lung tissue perturbations and creates a tumour-supportive microenvironment

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Emma Nolan1,Ilaria Malanchi1
1Francis Crick Institute

Do Neutrophil Counts Pre-chemotherapy Treatment provide Clinical Value.

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Pinkie Chambers1,Li Wei2,Yogini Jani3,Ian Wong4
1UCLH NHS Foundation Trust,2UCL School of Pharmacy,3UCL/UCLH Centre for Medicines Optimisation Research and Education,4UCL Research Department of Pharmacy Practice

Evaluation of older patients in early phase clinical trials

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Jessica Lowe1,Rosie Lauste2,Tine Descamps3,Matthew Krebs1,Donna Graham1,Fiona Thistlethwaite1,Louise Carter1,Natalie Cook1
1The Christie NHS Foundation Trust, Manchester, UK,2University of Manchester, Manchester, UK,3Cancer Research UK, London, UK

Chemotherapy-Induced Peripheral Neuropathy: Incidence and Effect on Quality of Life

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Cheney Wong1
1University of Manchester

A national audit of cardiopulmonary resuscitation discussions with patients admitted to acute oncology ward

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Isabel Tol1,Robert Watson2,Elspeth Cumber3,Ami Sabharwal4,Andrew Protheroe4,Ashling Lillis3,Daphne Nakakande5,Silvana Wijaya5,Catherine Turberfield5,Abdul Badran5,Safia Siddiqui5,Prakhar Srivastava6,Bethany Chung7,Molly Dineen8,Cariosa Devlin8,Claire Worrall1
1University of Oxford,2Oxford University hospitals,3Macmillan,4Oxford University Hospitals,5University of Cambridge,6University of Manchester,7Kings College London,8University of Exeter

The effect of combined FOLFOX with metformin in colorectal cancer cell

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Jaw Yuan Wang1,Jaw Yuan Wang2
1Kaohsiung Medical University Hospital, Kaohsiung Medical University,2Kaohsiung Medical University and Hospital

Silvestrol sensitises breast cancer cells to radiation

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Thomas Webb1
1East Kent Hospitals University NHS Foundation Trust, Kent, UK

A novel role of BAP1 in regulating the spindle assembly checkpoint and mitotic spindle assembly

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Anita Singh1,Dean Fennell1,Andrew Fry1
1University of Leicester, Leicester, UK

FGF1 and HSP27 Interact to Modulate the DNA Damage Response in Chemoresistant Ovarian Cancer Cells

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Hugh A. Nicholson1,Michelle J. Ferguson2,Gillian Smith1
1University of Dundee,2NHS Tayside

Investigating resistance mechanisms to glutaminase inhibition in renal cell carcinoma using a genome-wide CRISPR/Cas9 approach.

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Aleksandra Raczka1,Aleksandra Raczka1,Paul Reynolds1
1School of Medicine, University of St Andrews

Does recruitment to cancer clinical trials at the Leicester Royal Infirmary reflect the ethnic diversity of those receiving systemic anticancer therapy?

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Adrian Nicholson1,Mohammed Karolia1,Emily de Groot2,Sarah Nicholson1,Devinder Dhillon1,Lynne Howells3,Harriet Walter3,Anne Thomas3
1University Hospitals Leicester, Leicester, UK,2University of Leicester Medical School, Leicester, UK,3Leicester Cancer Research Centre, Leicester, UK

Patient recruitment for observational and interventional research studies in anal cancer in Leeds, England for 2013-2018

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Robert Samuel1,David Sebag-Montefiore2,Katie Spenver1,Alex Gilbert1,Nathalie Casanova3,Rachel Cooper3,Louise Loughman3,Pamela Shuttleworth3
1University of Leeds,2Universit of Leeds,3Leed University Teaching Hospitals NHS Foundation Trust

Variation in pre-diagnostic investigation use and test-to-diagnosis intervals by comorbidity status and socio-demographic characteristics in patients subsequently diagnosed with colorectal cancer

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Sara Benitez Majano1,Georgios Lyratzopoulos2,Bernard Rachet1,Cristina Renzi2
1LSHTM,2UCL

Time on treatment and treatment patterns in patients with metastatic colorectal carcinoma: a retrospective chart review

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Anna Ryan1,Daniel Sugrue2,Michael Hurst2,Pratik Thakkar3,Sidonie Hartridge-Lambert3,Hamzeh Kayhanian1,Jason Gordon2,Manuel Rodriguez-Justo1,Kai-Keen Shiu1,Dionysios Ntais3
1University College London Hospital,2Health Economics and Outcomes Research Ltd.,3Bristol-Myers Squibb

Predicting platinum chemotherapy sensitivity in advanced oesophageal cancer using a DNA Damage Immune Response (DDIR) assay

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Mark Baxter1,Shaun Walsh2,Russell Petty1
1University of Dundee,2NHS Tayside