420 abstracts found.



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REACT (REal-time Analytics for Clinical Trials): supporting decision-making for early cancer trials

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Fouziah Butt1,Dónal Landers1,Paul Fitzpatrick1,Julie Stevenson1,Laura Stephenson1,Richard Hoskins2
1Cancer Research UK, Manchester Institute - digital Experimental Cancer Medicine Team,2The University of Manchester, Research IT

Integrating cancer care in the community

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Libby Eastwood1,Fiona Flowers1,Josh McLuckie1
1Macmillan Cancer Support

Quantitative secretomics analysis of stem and non-stem cells of two different stages of colon cancer cell lines

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Jeyalakshmi Kandhavelu1,Kumar Subramanian1,Previn Naicker2,Stoyan Stochev2,Paul Ruff1,Clement Penny1
1University of the Witwatersrand,2Council for Scientific and Industrial Research

Real world experience from the use of neoadjuvant FLOT in patients with resectable oesophageal, gastrooesophageal junction (GOJ) and gastric adenocarcinomas. A Yorkshire network audit.

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Danny Ulahannan1,Konstantinos Kamposioras2,Jeremy Hayden1,Daniel Swinson1,Jonathan Wadsley3,Jessica Tay3,Usman Ahmad4,Simon Brown5,Sohail Mughal5,Jo Dent6,Elizabeth Appleton6,Rajarshi Roy7,Ornella Belvedere8,Kim Last8,Mohan Hingorani1,Matt Seymour1
1Leeds Teaching Hospital,2Christie Hospital,3Weston Park cancer centre, Sheffield,4Mid Yorkshire hospital NHS trust,5Bradford Teaching hospital,6Calderdale and Huddersfield NHS trust,7Hull University teaching hospital,8York teaching hospital

Impact of lung and cardiac dose on the survival of oesophageal cancer patients following single modality radiotherapy

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Matthew Hatton1,Bilal Tahir2,Helen Joyce3,Lynne Dixon3,Joseph Bradshaw4,Selina Hardy4,Stephen Tozer-Loft4,Jon Wadsley5
1Weston Park Hospital,2Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, UK,3Department of Clinical Oncology, Weston Park Hospital, Sheffield, UK,4Department of Radiotherapy Physics, Weston Park Hospital, Sheffield, UK,5Academic Unit of Clinical Oncology, University of Sheffield, Sheffield

Development and user-testing of a brief decision aid for aspirin as a preventive approach alongside screening for colorectal cancer

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Lenira Semedo1,Kate Lifford1,Adrian Edwards1,Katherine Brain1,Kathy Seddon2,Stephanie Smits1,Sunil Dolwani1
1Cardiff University,2PPI partner

A novel synthetic Indoline derivative induces apoptosis in mid and late stage colorectal cancer cell lines

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Vivash Naidoo1,Jeyalakshmi Kandhavelu2,Kumar Subramanian3,Meenakshisundaram Kandahvelu4,Paul Ruff2,Clement Penny2
1university of the witwatersrand,2University of the Witwatersrand,3University of the witwatersrand,4Molecular Signalling Lab, Faculty of Medicine and Health Technology, BioMediTech, Tampere University and Tays Cancer Centre

Cancer Quality of Life Metric Project – Testing ways of presenting patient quality of life summary scores to patients and health professionals.

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Sarah Gelcich1,Sophia Taylor2,Alison Richardson3,Galina Velikova1,Alice Simon4,Cancer Quality of Life Working Group Cancer Quality of Life Steering Group4
1University of Leeds,2University of Southampton,3University Hospital Southampton NHS Foundation Trust and University of Southampton,4NHS England

Hedgehog signals inhibitors reverse sorafenib resistance in patient-derived organoids models with hepatocellular carcinoma

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Siqi Wang1,Jiye Zhu1,Zhao Li1,Yang Wang1
1Department of Hepatobiliary Surgery, Peking University People’s Hospital

Molecular and functional studies on a sub-population of T cells resistant to Galectin-9

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Thi Bao Tram Tran1,Aurore Gelin1,Philippe Rameau1,Cyril Catelain1,Valentin Baloche1,Pierre Busson1
1Gustave Roussy Institute, Villejuif, France

Effective clinical cancer treatment, care and management for people with comorbid cancer and dementia: understanding population demographics and intervention priorities and outcomes (CanDem-Int)

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Michelle Collinson1,Ellen Mason1,Laura Ashley2,Amanda Farrin1,Alys Griffiths3,June Hennell4,Rachael Kelley3,Claire Surr3
1Clinical Trials Research Unit, University of Leeds, Leeds, UK,2School of Social Sciences, Leeds Beckett University, Leeds, UK,3Centre for Dementia Research, Leeds Beckett University, Leeds, UK,4Centre for Dementia Research Expert by Experience group, Leeds Beckett University, Leeds, UK

SWATH mass spectrometry: Quantitative mapping of soft tissue sarcomas by digital proteome profiling

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Lukas Krasny1,Martina Milighetti1,Alexander T.J. Lee1,Aik-Choon Tan2,Robin Jones3,Paul H. Huang1
1The Institute of Cancer Research, London, UK,2University of Colorado, Aurora, US,3Royal Marsden Hospital, London, UK

Repurposing loperamide to overcome gefitinib resistance by triggering apoptosis independent of autophagy induction in KRAS mutant NSCLC cells

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Christy Wing Sum Tong1,Mia Mingxia Wu1,Wei Yan1,Kenneth Kin Wah To1
1The Chinese University of Hong Kong

Does augmenting the complement system improve Rituximab induced cell lysis?

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Katy Plant1
1Cardiff University School of Medicine

Detection of EGFR mutations in the plasma and urine of NSCLC EGFRm+ patients

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Ling Li1,Sebastian Oltean1,Helen Brooks2,Charles Comins2,Alfredo Addeo2,Megan Stevens1
1University of Exeter,2University Hospitals Bristol NHS Foundation Trust

A Systematic Review of the Economic Costs of Gastrointestinal Consequences of Treatment for Cancer Patients and Healthcare Providers

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Mirella Longo1,Alison Weightman2,Anne Muls3,Annmarie Nelson1,Jervoise Andreyev3,John Staffurth4,Lesley Smith5,Mala Mann2
1Cardiff University, School of Medicine, Marie Curie Palliative Care Research Centre, Cardiff,2Cardiff University, Specialist Unit for Review Evidence (SURE), Cardiff,3The Royal Marsden NHS Foundation Trust, London,4Cardiff University, School of Medicine, Cardiff,5NHS England and NHS Improvement, London

Combination of caloric restriction and lysine-specific demethylase 1 (LSD1) inhibition in the treatment of acute myeloid leukemia

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Rani Pallavi1,Luca Mazzarella1,Tiphanie Durfort1,Elena Gatti1,Bruno Achutti Duso1,Massimo Stendardo1,Luciano Giaco1,Ciro Mercurio2,Mario Varasi2,Marco Giorgio1,Saverio Minucci1,Pier Giuseppe Pelicci1
1European Institute of Oncology,2FIRC Institute of Molecular Biology

Expression Levels of hsa-miR-590-3p in Hepatocellular Carcinoma and Osteosarcoma Cell Lines and its Downstream Target Genes

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Mennatallah Elfar1,Asma Amleh2
1Generations Labs,2The American University in Cairo

The risk of ischemic cerebrovascular disease in head and neck cancer patients after radiotherapy

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Suzy Kim1,Jin Yong Lee1,Young Ae Kim2,Young Ho Jung3
1SMG-SNU Boramae Medical Center, Seoul,23National Cancer Control Institute, National Cancer Center, Goyang,3Seoul National University Bundang Hospital, Seongnam

Investigating the importance of BCL-3/β-catenin signalling in colorectal tumorigenesis

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Penny Timms1,Danny Legge1,Tracey Collard1,Adam Chambers1,Ann Williams1
1University of Bristol

The Roles of Gelsolin in the Regulation of Wnt Signaling in Colorectal Cancer

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Mei Shan Ong1,Shuo Deng1,Tuan Zea Tan2,Shing Chuan Hooi1,Alan Prem Kumar3,Celestial T. Yap1
1National University of Singapore,2Cancer Science Institute,3National University of Singapore, Cancer Science Institute

The continual reassessment method for phase I clinical trial design: is it always more efficient than the 3+3?

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Samantha Hinsley1
1Clinical Trials Unit, Cancer Research UK, Glasgow, UK

Is pelvic examination a key part of a patient’s gynaecological cancer diagnostic journey? A qualitative study of GPs and specialists.

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Pauline Williams1,Maggie Cruickshank1,Christine Bond1,Christ Burton2,Peter Murchie1
1University of Aberdeen,2University of Sheffield

Survival outcomes in oropharyngeal cancer: a decision tree analysis

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Francesca De Felice1,Laia Humbert-Vidan2,Mary Lei2,Andrew King2,Teresa Guerrero Urbano2
1Guy's and St Thomas' NHS Foundation Trust, London, Sapienza University of Rome, Rome, Italy,2Guy’s and St Thomas’ NHS Foundation Trust, London, UK

Embracing the Digital Age in Oncology Outpatients. A Qualitative Study

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Pippa Bullard1,Catherine Sharma1,Claire Diver2
1Nottingham University NHS Trust,2University of Nottingham

A predictive model to estimate the probability of EGFR mutation(s) in New Zealand patients with non-squamous NSCLC

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Phyu Aye1,Sandar Tin Tin1,Mark McKeage1,Prashannata Khwaounjoo1,Arier Lee1,Alana Cavadino1,Mark Elwood1
1The University of Auckland

MAESTRO/PERSEUS: A phase II molecular stratification/treatment platform in Metastatic Castration Resistant Prostate Cancer (mCRPC) – PERSEUS1 (pembrolizumab; NCT03506997)

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Pasquale Rescigno1,Stephanie Burnett1,Nuria Porta1,Ajit Sarvadikar1,Penelope Flohr1,Ines Figueiredo1,Diletta Bianchini2,Suzanne Carreira1,Ruth Riisnaes1,Susana Miranda1,Mateus Crespo1,Bora Gurel1,Maryou B. Lambros1,Claudia Bertan1,Matthew Clarke1,George Seed1,Ana Ferreira1,Ana Rita da Silva Pereira1,Emma Hall1,Johann de Bono2
1The Institute of Cancer Research,2The Institute of Cancer Research & The Royal Marsden NHS Foundation Trust

Exploring estrogen receptor(ER)+ve breast cancer survivors’ and health care professionals’ views and experiences of weight management(physical activity and nutrition) before, during and post treatment

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Katie Pickering1,Sarah Wane2,Helen Crank1,Annie Anderson3,Janet Brown4,Henry Cain5,Rob Copeland1,Kate Kendell5,Daniela Lee5,Peter McMeekin2,Richard McNally6,Laura Thomas7,Caroline Wilson8,John Saxton2
1Sheffield Hallam University,2Northumbria University,3University of Dundee,4University of Sheffield,5Newcastle Upon Tyne NHS Trust,6Newcastle University,7Liverpool John Moores University,8University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust

Immune-related hypophysitis: a tertiary referral centre experience

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Ionut-Gabriel Funingana1,Sarah Welsh1,Benjamin Devoy1,Christine Parkinson1,Krishna Chatterjee1,Pippa Corrie1
1Cambridge University Hospitals NHS Foundation Trust

Accurate targeted long-read DNA methylation sequencing with TAPS.

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Yibin Liu1,Yibin Liu1,Jingfei Cheng1,Paulina Siejka-Zielinska1,Chunxiao Song1
1University of Oxford

Assessment and monitoring of cardiotoxicity in Breast Cancer patients treated with  HER2-directed Agents (Trastuzumab, Pertuzumab, and Ado-trastuzumab emtansine (T-DM1)

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Sudha Karanam1,Mariam Jafri1,Daniel Rea1,Nyein Su Tun1
1University Hospital Birmingham NHS Trust

Investigating the interaction between phosphodiesterase 4D7 (PDE4D7) and DHX9 in the progression of prostate cancer

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Tara Busiau1,Jane Finlay1,Joanne Edwards1,Ralf Hoffman2,George Baillie1
1University of Glasgow,2Philips Diagnostics

Excellent pathological complete response (pCR) rate with chemotherapy and dual anti-HER2 therapy in HER2 positive locally advanced breast cancer – the experience at Lincoln County Hospital

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Rajeev Nair1,Michelle Kok Pei Ling1,Abhro Chaudhuri1
1Lincoln County Hospital

People with cancer living in deprived areas of Wales are more likely to have another serious condition at diagnosis than those in the least deprived areas

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Tamsin Long1,Dyfed Wyn Huws1,Julie Howe1,Tomos Smith1,Kelly Shiell-Davis2,Adele Oddy2,David Egan2,Rebecca Thomas1
1Public Health Wales,2Macmillan Cancer Support

Protein Phosphatase 4 Regulatory Subunit 3A regulates leukemic cell survival independent of PP4 catalytic subunit

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Mirna Mourtada-Maarabouni1,Nadieh Kavousi2
1Keele University,2University of Keele

Smoking cessation for cancer prevention: Can incentives play a role? Evidence from a Cochrane review

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Caitlin Notley1,Sarah Gentry2,Jonathan Livingstone-Banks3,Linda Bauld4,Rafael Perera3,Jamie Hartman-Boyce3
1Norwich Medical School, Norwich, UK,2University of East Anglia, Norwich, UK,3Cochrane, University of Oxford, Oxford, UK,4University of Edinburgh, Edinburgh, UK

ASSESSMENT & MANAGEMENT OF CANCER RELATED FATIGUE ON THE LIVES OF PATIENTS

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Ishrat Rafique Eshita1,N/a N/a2,N/a N/a2,N/a N/a3,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2,N/a N/a2
1National Institute of Preventive & Social Medicine, Bangladesh,2n/a,31987

Atezolizumab for locally advanced or metastatic urothelial carcinoma of the urinary tract: Analysis of UK patients treated in the international SAUL study

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Robert Huddart1,Jason F Lester2,Guy Faust3,Neil McPhail4,Hajer Lassidi5,Simon Fear6,Thomas Powles7
1Institute of Cancer Research,2Velindre Cancer Centre, Cardiff (current affiliation: Swansea Bay University Health Board, Singleton Hospital, Swansea),3Leicester Royal Infirmary NHS Trust, Leicester,4Raigmore Hospital, Inverness,5Roche Products Ltd, Welwyn Garden City,6F Hoffmann-La Roche Ltd, Basel,7Barts Cancer Institute, Experimental Cancer Medicine Centre, Queen Mary University of London, St Bartholomew’s Hospital, London

An investigation of eating problems in people with stage I-III colorectal cancer receiving Systemic Anti-Cancer Therapy (SACT): the potential for nutritional care to potentiate cancer treatment

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Jane Hopkinson1,Catherine Kazmi1,Jayne Elias2,Sally Wheelwright3,Clare Shaw4,Ann Russell5,Gillian Knight6,Lisa Love-Gould7,Rhiannon Williams7,Barbara Burbidge8
1Cardiff University,2Velindre NHS Trust,3University of Southampton,4The Royal Marsden Hospital,5Independent Patient Representative,6Welsh Government,7Velindre Cancer Centre,8Velindre Patient Liaison Group

The Trigger project: Introducing electronic patient reported outcome measures into radiotherapy services

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Amy Sharkey1,Archie MacNair2,Kerlann Le Calvez3,Robert Walters4,Lesley Smith5,David Bloomfield6,Annmarie Nelson7,John Staffurth8,Matthew Williams3,Jane Maher9
1Macmillan Cancer Support, London, UK & Royal College of Radiologists, London, UK ,2Macmillan Cancer Support, London, UK & Royal College of Radiologists, London, UK,3Imperial College Healthcare NHS Trust, London, UK,4Pelvic Radiation Disease Association, Epsom, UK,5NHS England National Cancer Programme, London, UK,6Brighton and Sussex University Hospitals NHS Trust, Brighton, UK,7Marie Curie Research Centre, London, UK,8Velindre NHS Trust, Cardiff, UK,9Macmillan Cancer Support, London, UK

Geographical variation in access to ovarian cancer treatment in England.

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Ewa Zotow1,Rosie Hinchliffe1,Hira Naveed1,John Butler2
1Cancer Research UK,2NHS; Cancer Research UK

Safety and efficacy of 12 mg/d lenvatinib (LEN) in patients with unresectable hepatocellular carcinoma (uHCC) and bodyweight >80 kg in REFLECT

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Arndt Vogel1,Masatoshi Kudo2,Ann-Lii Cheng3,Max W. Sung4,Richard S. Finn5,Albert Y. Lin6,Ghassan K. Abou-Alfa7,Angel Alsina8,Valeriy Breder9,Niall Tebbutt10,Pia Osterlund11,C. J. Yen12,Min Ren13,Soamnauth Misir13,Corina E. Dutcus13,Daniel Palmer14,Philippe Merle15,Matthias Pinter16,TR Jeffry Evans17
1Hannover Medical School,2Kindai University School of Medicine,3National Taiwan University Hospital,4Tisch Cancer Institute at Mount Sinai,5Geffen School of Medicine, UCLA Medical Center,6VA Palo Alto Health Care System,7Memorial Sloan Kettering Cancer Center,8Tampa General Hospital,9N.N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation,10Olivia Newton-John Cancer Centre,11Tampere University and Central Hospital,12National Cheng Kung University Hospital,13Eisai Inc.,14University of Liverpool, Liverpool,15CHU de Lyon -Hospital La Croix-Rousse,16Medical University of Vienna,17University of Glasgow

Acupuncture for the treatment of paraneoplastic night sweats.

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Visweswaran Ramasamy1
1John Taylor hospice

Assessment of the role of the preoperative neutrophil-lymphocyte ratio as a prognostic biomarker in nonmetastatic rectal cancer

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Manar Almusarhed1,Osamah Al-Asadi1,Azhar Rizvi1,Anil Hermanad1,Qamar Zaman1,Somnath Mukherjee1,Hany Eldeeb1
1Milton Keynes Universiy Hospital

Elevated Parkinson’s-like tumour signalling from very early-stage colorectal cancer is associated with disease relapse

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Aoife McCooey1,Keara Redmond1,Emma Kerr1,Daniel Longley1,Philip Dunne1,S-cort Consortium2
1Queen's University Belfast,2S:CORT Consortium

Biweekly cetuximab in combination with capecitabine and oxaliplatin (XELOX) or irinotecan (XELIRI) in patients with metastatic colorectal cancer

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Jamal Zekri1,Ehab Mosaad2,Refaei Belal Ibrahim3,Kamel Mohamed Kamal4,Adnan Hussain5,Mohammed Abbas Baghdadi6
1College of Medicine, Al-Faisal University, King Faisal Specialist Hospital (Jeddah),2Medical oncology department, National Cancer Institute, Cairo University,3Department of clinical oncology and nuclear medicine. Faculty of medicine Al Azhar University,4Cairo University,5King Faisal Specialist Hospital and Research Center- Jeddah,6Research Centre, King Faisal Specialist Hospital & Research Centre, Jeddah

Explaining socio-economic differences in bladder cancer survival

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Beth Russell1,Mieke Van Hemelrijck1,Truls Gårdmark2,Lars Holmberg1,Pardeep Kumar3,Andrea Bellavia4,Christel Häggström5
1King's College London, London, UK,2Karolinska Institute, Stockholm, Sweden,3Royal Marsden NHS Foundation Trust, London, UK,4Havard T.H Chan School of Public Health, Boston, US,5Uppsala University, Uppsala, Sweden

Outcomes in patients age 70 and above treated with radical radiotherapy for Head & Neck Cancer

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Saurabh Borgaonkar1,Lisa Hay1,Claire Paterson1,Derek Grose1,Carolynn Lamb1,Stephano Schipani1,Christina Wilson1,Allan James1,Maureen Thomson1
1Beatson

GYS1 inhibition and synthetic lethality with mitochondrial inhibitors in breast cancer

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Ellen de Heer1,Christos E Zois1,Syed Haider2,Daniel Ebner1,Andrew Ratcliffe3,Adrian Harris1
1University of Oxford, Oxford, UK,2Institute of Cancer Research, London, UK,3Novintum Bioscience, London, UK

Metabolic syndrome and renal cell cancer risk in Chinese males: a population-based prospective study.

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Xin Li1,Gang Wang2,Xiaoshuang Feng1,Zhangyan Lyu1,Luopei Wei1,Yan Wen1,Shuohua Chen3,Shouling Wu3,Hongda Chen1,Ni Li1,Min Dai1,Jie He1
1National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,2Kailuan General Hospital,3Health Department of Kailuan (Group)