254 abstracts found.



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The impact of the COVID-19 pandemic on cancer diagnostic pathways in children, teenagers and young adults: a cohort study in England

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Defne Saatci1, Jason Oke1, Anthony Harnden1, Julia Hippisley-Cox1
1University of Oxford

Molecular screening of urine for Mismatch Repair deficient urothelial tumours; an under-appreciated cancer in Lynch syndrome

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Rachel Phelps1, John Burn1, Christine Hayes1, Richard Gallon1, Jo Pethick2, Fiona McRonald2, Steven Hardy2, Peter Gawthorpe1, Gillian Borthwick1, Mauro Santibanez-Koref1, Michael Jackson1
1Newcastle University, 2Public Health England

Circulating Tumour Cell Analysis to Evaluate Docetaxel Treatment Response and Resistance Markers in Prostate Cancer

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Caitlin Davies1
1Barts Cancer Institute

A global review of publicly available open-access skin cancer image datasets used in development of machine learning algorithms for skin cancer diagnosis

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David Wen1, Saad Khan2, Antonio Ji-Xu3, Hussein Ibrahim4, Luke Smith5, Jose Cabellero5, Luis Zepeda5, Les Mara5, Alastair Denniston1, Xiaoxuan Liu1, Rubeta Matin3
1University of Birmingham, 2Royal Berkshire NHS Foundation Trust, 3Oxford University Hospitals NHS Foundation Trust, 4University Hospitals Birmingham NHS Foundation Trust, 5Other

The influence of ethnicity on survival in malignant brain tumours in England: a population-based cohort study

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Hiba Wanis1, Elizabeth Davies1, Henrik Møller1, Keyoumars Ashkan1
1King’s College London (KCL)

Patient and treatment factors associated with adverse quality of life 2 years following radiotherapy – results from the REQUITE breast cancer patient cohort

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Tim Rattay1, Harkeran Jandu2, Colin Veal2, Petra Seibold3, David Azria4, Ananya Chaudhury5, Alison Dunning6, Dirk de Ruysscher4, Sara Gutierrez-Henriquez7, Philippe Lambin8, Tiziana Rancati4, Barry Rosenstein9, Elena Sperk4, R Paul Symonds2, Christopher Talbot2, Riccardo Valdagni4, Ana Vega4, Liv Veldeman4, Adam Webb2, Hilary Stobart4, Catharine West10
1University of Leicester, Leicester, UK, 2University of Leicester, 3German Cancer Research Center (DKFZ), 4Other, 5The Christie NHS Foundation Trust, 6University of Cambridge, 7Vall d’Hebron Institute of Oncology, 8Maastricht University, 9Icahn School of Medicine at Mount Sinai (ISMMS), 10University of Manchester

Efficacy of avelumab + axitinib (A + Ax) vs sunitinib (S) by IMDC risk group in advanced renal cell carcinoma (aRCC): extended follow-up results from JAVELIN Renal 101

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John Haanen1, James Larkin2, Toni Choueiri3, Laurence Albiges1, Brian Rini4, Michael Atkins1, Manuela Schmindinger1, Konstantin Penkov1, Despina Thomaidou1, Jing Wang5, Mariangela Mariani1, Alessandra di Pietro1, Robert Motzer6
1Other, 2Royal Marsden NHS Foundation Trust, 3Dana-Farber Cancer Institute, 4Vanderbilt-Ingram Cancer Center, 5Pfizer, 6Memorial Sloan-Kettering Cancer Center

Assessment of response and toxicity for recurrent glioblastoma to single-agent Lomustine (CCNU) – A single centre experience

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Chevonne Tan1, Helen Wong2, Helen Flint2, Eswar Chinnamani2, Chloe May2, Aditya Shenoy2, Shaveta Mehta2
1Hull University Teaching Hospitals NHS Trust, 2Clatterbridge Cancer Centre NHS Foundation Trust

Optimising the delivery of breast cancer risk estimates to women aged 30-39 years: women’s views

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Sarah Bellhouse1, Louise Gorman1, Sacha Howell1, Rhiannon Hawkes1, David French1, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2, N/a N/a2
1University of Manchester, 2Other

Quality of life in adults with low grade gliomas: a systematic review

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Ben Rimmer1, Iakov Bolnykh1, Lizzie Dutton1, Fiona Menger1, Linda Sharp1
1Newcastle University

CREDIT (Cancer Related Escalation Decisions for ITU) Study; Survival, functional status and return to anti-cancer therapy in advanced solid tumour patients after emergency admission to critical-care

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Rachel Marshall1, Alec Maynard1, Bilal Tahir2, Hayley Boyce1, Richard Harrold1, Martha Eldridge1, Jessica Johnson1, Danielle Meehan1, Rachel Spiro1, Amanda Swan3, Anna Ratcliffe4, Helena Jennison4, Sarah Kingdon4, Andrew Cruikshanks1, Caroline Wilson1
1Sheffield Teaching Hospitals NHS Foundation Trust, 2University of Sheffield, 3Edinburgh Cancer Centre, 4Derriford Hospital

Volunteers as lifestyle coaches in a clinical trial – experiences from Breast Cancer Now on the ActWELL trial

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Amy Hickman1, Hanne Bruhn2, Shaun Treweek2, Annie. S Anderson3
1Breast Cancer Now, 2University of Aberdeen, 3University of Dundee

Neutropenic Sepsis One Hour Door-To-Needle Target in the Emergency Department: A Clinical Audit During the Covid-19 Pandemic

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Jonathan Martin1, Claire Pettinger2, Benjamin Mckechnie2, Lee Grimes2, Simon Hunter2, Margaret Pople2, Effie Grand2
1University of Southampton, 2Salisbury NHS Foundation Trust

ATNEC: A multicentre, randomised trial investigating whether axillary treatment can be avoided in patients with no residual cancer in the lymph glands after neoadjuvant chemotherapy

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Amit Goyal1, Janet Dunn2, Sophie Cramp2, Andrea Marshall2, Duncan Wheatley3, Natalie Hammonds2, Shama Puri1, Tara Homer4, Luke Vale4, Romaana Mir5, Janice Rose6, Helen Teresa Edwards7, Samreen Ahmed8, Abeer Shaaban9, Beatrix Elsberger10, Julie Bruce2, Sophie Gasson2, Valerie Speirs11, Jacqui Shaw12, Helen Higgins2
1University Hospitals of Derby and Burton NHS Foundation Trust, 2University of Warwick, 3Royal Cornwall Hospitals NHS Trust, 4Newcastle University, 5Mount Vernon Cancer Centre, 6National Cancer Research Institute (NCRI), 7Independent Cancer Patients’ Voice (ICPV), 8University Hospitals of Leicester NHS Trust, 9University Hospitals Birmingham NHS Foundation Trust, 10NHS Grampian – Aberdeen Royal Infirmary, 11University of Aberdeen, 12University of Leicester

The nuclear hormone receptor cofactors prohibitin-2 (PHB2) and tetratricopeptide repeat domain 5 (TTC5) exert opposite effects in breast tumorigenesis

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Kawther Almazroee1, Constantinos Demonacos1, Ayşe Latif1
1University of Manchester

Adrenal Insufficiency following Prolonged Exogenous Steroid Treatment for Graft Versus Host Disease

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Ann Tivey1, Henry Simons1, John Murray1, Claire Higham1
1The Christie NHS Foundation Trust

Optimising Supported Early Discharge Follow-up care for women with Breast Cancer in the UK – a qualitative analysis

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Lyndel Moore1, Eila Watson2, Lyndel Moore1, Lauren Matheson2, Jo Brett2, Verna Lavender3, Bernadette Lavery4, Anne Kendall1
1Great Western Hospital, 2Oxford Brookes University, 3Guy’s and St Thomas’ NHS Foundation Trust, 4Oxford University Hospitals NHS Foundation Trust

Alcohol intake and endogenous hormones in pre- and post-menopausal women: findings from the UK Biobank

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Sandar Tin Tin1, Timothy J Key1, Gillian K Reeves1
1University of Oxford

Patients’ experiences of a suppoRted self-manAGeMent pAThway In breast Cancer (PRAGMATIC): 3 month quality of life results

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Valerie Jenkins1, May Teoh2, Lucy Matthews2, Manish Kothari2, David Bloomfield2, Shirley May2, Charles Zammit2, Dibendu Betal2, Regina Santos2, Kay Nicholson2, Debbie Elwell-Sutton2, Fiona McKinna2, Heather Gage2, Stephanie Bell2
1University of Sussex, 2Other

Physical activity interventions and health-related quality of life in women with breast cancer: A systematic literature review of the World Cancer Research Fund/American Institute of Cancer Research

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Dagfinn Aune1, Georgios Markozannes1, Leila Abar1, Katia Balducci1, Margarita Cariolou1, Neesha Nanu1, Ana Rita Vieira1, Steven Clinton2, Edward L Giovannucci2, Marc J Gunter3, Alan Jackson4, Ellen Kampman2, Viv Lund2, Anne McTiernan5, Kate Allen6, Nigel Brockton7, Helen Crocker6, Daphne Katsikioti6, Deirdre McGinley-Gieser7, Panagiota Mitrou6, Martin Wiseman6, Galina Velikova2, Wendy Demark-Wahnefried8, Teresa Norat1, Konstantinos K Tsilidis1, Doris S.M. Chan1
1Imperial College London, 2Other, 3International Agency for Research on Cancer (IARC), 4University of Southampton, 5Fred Hutchinson Cancer Research Center, 6World Cancer Research Fund International, 7American Institute for Cancer Research, 8University of Alabama at Birmingham

Comprehensive evaluation of risk factors associated with immune checkpoint blockade-induced hepatitis

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Colin Lee1, Joanna Kucharczak1, Bruno De Paula1, George Mells1, Sarah Welsh1
1Cambridge University Hospitals NHS Foundation Trust

WHY spend time outdoors? Nature can aid psychosocial and emotional wellbeing in those living with or beyond cancer

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Moa Sundström1
1King’s College London (KCL)

A scoping review to determine levels of knowledge, attitudes and screening practices towards breast and cervical cancer among women in Nepal

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Candice Rademaker1, Helena Harder1
1Brighton and Sussex Medical School

A meta-ethnography of cultural and relational influences on cancer-related psychological interventions

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Damien Ridge1, Karen Pilkington2, Sheila Donovan3, Elisavet Moschopoulou3, Dipesh Gopal3, Kamaldeep Bhui4, Trudie Chalder5, Imran Khan3, Stephanie Taylor3, Ania Korszun3
1University of Westminster, 2University of Portsmouth, 3Queen Mary University of London, 4University of Oxford, 5King’s College London (KCL)

Investigating the oncogenic properties of HER2 splice variants in breast cancer.

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Victoria Hart1
1Newcastle University

Value of a simple neurocognitive test at GP Referral for CT scan for Headache Suspicious of Cancer – a “red flag” for tumour.

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Robin Grant1, Karolis Zeinius2, Will Hewins1, David Summers3, Lesley McKinlay3, Paul Brennan1, Lorna Porteous4
1University of Edinburgh, 2Hull Royal Infirmary, 3Royal Infirmary of Edinburgh, 4NHS Lothian

LARGEST SINGLE CENTRE SERIES OUTCOMES FOR WATCH AND WAIT (WW) IN RECTAL CANCER PATIENTS IN UNITED KINGDOM

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Rashi Mane1, Chris Rao1, Sandeep Kaul1
1Barking, Havering and Redbridge University Hospitals NHS Trust

Identification of a microbiome signature predicting immune checkpoint inhibitor outcomes across multiple cancer types: the MITRE study

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Pippa Corrie1, Sarah Welsh2, Grant Stewart2, Gary Doherty3, Kevin Vervier4, Anne Neville4, Christine Parkinson3, Kate Fife3, Guy Faust5, Kamalram Thippu Jayaprakash4, Thomas Geldart6, Ewan Brown7, Matthew Wheater8, Jenny Nobes9, Tania Tillett10, Toby Talbot11, Clare Barlow12, Helen Winter4, David Bruce3, Katy Dalchau3, Nikos Demiris3, David Adams13, Mat Robinson4, Trevor Lawley4
1Addenbrooke’s Hospital, 2University of Cambridge, 3Cambridge University Hospitals NHS Foundation Trust, 4Other, 5University Hospitals of Leicester NHS Trust, 6Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, 7Western General Hospital, 8University Hospital Southampton NHS Foundation Trust, 9Norfolk & Norwich University Hospitals NHS Foundation Trust, 10Royal United Hospitals Bath NHS Foundation Trust, 11Royal Cornwall Hospitals NHS Trust, 12Somerset NHS Foundation Trust, 13Wellcome Sanger Institute

Comparative response of head and neck cancer cells to photons and protons: Optimising radiosensitivity through targeting the DNA damage response

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Jason Parsons1, Maria Rita Fabbrizi1, Rachel Carter1, Catherine Nickson1, Eirini-Terpsi Vitti1, Mark Hill2
1University of Liverpool, 2University of Oxford

Patterns of care of  first line systemic treatment of advanced renal cell cancer (aRCC) patients before and during the covid-19 pandemic

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Jessica Ball1, Amarnath Challapalli1, Zoe Hudson1, Amit Bahl1
1University Hospitals Bristol NHS Foundation Trust

Bone Health and Androgen Deprivation Therapy For Advanced Prostate Cancer: A Clinical Audit Report of Baseline FRAX Scores

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Jonathan Martin1, Simon Crabb2, Vanessa Basketter2
1University of Southampton, 2University Hospital Southampton NHS Foundation Trust

A North west London experience of use of Immunotherapeutic drugs in advanced renal cancer during COVID-19 pandemic

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Anand Sharma1, Salma Alam1, Joanne Kwa2, Yatri Shah1, Rebecca Devine1, Andrew Gogbashian3, Paul Nathan1
1Mount Vernon Cancer Centre, 2East and North Hertfordshire NHS Trust, 3Paul Strickland Scanner Centre

Multiplex blood and tissue biomarkers for early lung cancer detection in a population undergoing computed tomographic (CT) screening: the iDx-Lung study

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Michelle Chesters1, Peter Johnson1, Victoria Goss1, Jocelyn Walters1, Darran Ball1, Claire Eckert2, Sam Wilding1, Jacqueline Nuttall1, Kathy Potter1, Debora Joseph-Pietras1, Kate Rolfvondenbaumen1, Catherine Pointer1, Hang Phan1, Bethany Shinkins2, Philip Crosbie3, Kevin Franks4, Isabel Macdonald5, Graham Healey5, Helen Oxford6, Paul Smith4, Ravinder Pabial7, Duncan Whitney8, Matthew Callister4, Richard Neal2, Gareth Griffiths1
1University of Southampton, 2University of Leeds, 3University of Manchester, 4Other, 5Oncimmune, 6Inivata, 7Roche, 8Johnson & Johnson

Concerns of gynaecological cancer patients during the COVID-19 pandemic and the role of cancer charities in supporting them: an investigation of patient-charity interactions.

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Pratyusha Saha1, Jameela Sheikh1, Meghnaa Hebbar1, Sudha Sundar1, Anne Lanceley2
1University of Birmingham, 2University College London (UCL)

Primary results of phase 2 FOENIX-CCA2: the irreversible FGFR1–4 inhibitor futibatinib in intrahepatic cholangiocarcinoma (iCCA) with FGFR2 fusions/rearrangements

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John Bridgewater1, Funda Meric-Bernstam2, Antoine Hollebecque3, Chigusa Morizane4, Juan W. Valle5, Thomas B. Karasic4, Thomas A. Abrams6, Robin Kate Kelley4, Philippe Cassier4, Junji Furuse4, Heinz-Josef Klümpen4, Heung-Moon Chang7, Li-Tzong Chen4, Yoshito Komatsu4, Kunihiro Masuda4, Daniel Ahn8, Yaohua He4, Nital Soni4, Karim A. Benhadji4, Lipika Goyal4
1UCL, 2MD Anderson Cancer Center, 3Institut Gustave Roussy, 4Other, 5University of Manchester, 6Dana-Farber Cancer Institute, 7Asan Medical Center, 8Mayo Clinic

Patients’ experiences of a suppoRted self-manAGeMent pAThway In breast Cancer (PRAGMATIC)

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Valerie Jenkins1, May Teoh2, Lucy Matthews2, Shirley May2, Manish Kothari2, David Bloomfield2, Fiona McKinna2, Charles Zammit2, Debbie Elwood-Sutton2, Stephanie Bell2, Heather Gage2, Regina Santos2, Elaine Stewart2, Dibendu Betal2, Kay Nicholson2, Judith Finlay2
1University of Sussex, 2Other

Harnessing liver-resident gamma delta T cells for immunotherapy of hepatocellular carcinoma

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Nekisa Zakeri1, Andrew Hall1, Leo Swadling1, Laura J Pallett1, Nathalie M Schmidt1, Mariana O Diniz1, Stephanie Kucykowicz1, Oliver E Amin1, Amir Gander1, Massimo Pinzani2, Brian R Davidson2, Alberto Quaglia2, Mala K Maini1
1University College London (UCL), 2Royal Free London NHS Foundation Trust

Information Needs around Parenteral nUTrition in cancer: INPUT

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Jennifer McCracken1, Lucy Eldridge1, Angela Halley1, Sally Wheelwright2, Jane Hopkinson3, Sam H Ahmedzai4, Adrian Tookman5, John Louis-Auguste6, Rebecca Harmston7, Deb Smith7, Clare Shaw1
1Royal Marsden NHS Foundation Trust, 2University of Southampton, 3Cardiff University, 4University of Sheffield, 5Marie Curie, 6St George’s University Hospitals NHS Trust, 7Other

Evaluation of learning interpretation of abbreviated breast MRI in novice MRI readers as part of the UK FAST MRI research programme.

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Sadie McKeown-Keegan1, Jan Rose2, Elizabeth O’Flynn3, Lyn Jones2, Rebecca Geach1, Janet Dunn4, Andrea Marshall4, Sian Taylor-Philips4, Mark Halling-Brown5, Premkumar Elangovan6
1North Bristol NHS Trust, 2No affiliation, 3St George’s University Hospitals NHS Trust, 4University of Warwick, 5Royal Surrey NHS Foundation Trust, 6Royal Veterinary College

Understanding Enhanced Supportive Care (ESC)

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Rachel Caulfield1, Jane Gibbins2, Karen Forbes1, Charlotte Chamberlain1
1University of Bristol, 2Royal Cornwall Hospitals NHS Trust

Survival analyses for determining clinical relevance of molecular markers in translational glioblastoma research – a systematic review

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Grace Loy1, Beth Fitt1, Edward Christopher2, Paul Brennan2, Michael Poon3
1University of Edinburgh, 2Royal Infirmary of Edinburgh, 3Cancer Research UK (CRUK) Edinburgh Centre

A systematic review for the screening of never-smokers who have a high risk of lung cancer

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Brent White1, Kate McBride1, Michael Denniss1, Claire Kim1, Joshua Downie1, Geoffrey Mai1, Tara Roberts1
1Western Sydney University

Real world data on outcome for HER2-positive metastatic breast cancer from two UK centres

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Louisa Stockton1, Lucy Gray1, Lorna Roden1, Liz Sherwin1, Mukesh Mukesh1
1East Suffolk and North Essex NHS Foundation Trust

Expanding the Landscape of Effective Therapy for Patients with Relapsed Mesothelioma

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Dean A. Fennell1, Gareth Griffiths2, Angela Casbard3, Lisette Nixon3, Catharine Porter3, Matthew Krebs4, Anne Thomas1, Amy King1, Catrin Pritchard1, James Harber1, Cathy Richards1, Amrita Bajaj5, Charlotte Poile1, Liz Darlison5, Apostolos Nakas5, Alan Dawson1, Aleksandra Bzura1, Jake Spicer1, Nada Nusrat1, Adam Pullen1, Hongji Yang1, Phillip Pan De Zhang1, Min Zhang6, Ed Hollox1, Frank Dudbridge1, Qianqian Sun6
1University of Leicester, 2University of Southampton, 3Cardiff University – Centre for Trials Research, 4Cancer Research UK (CRUK) Manchester Centre, 5University Hospitals of Leicester NHS Trust, 6Novogene

A novel mechanism that promotes mitotic spindle formation in cancer cells.

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Nikos Boutakoglou1, Eleni Petsalaki1, Sergio Lilla2, Sara Zanivan2, George Zachos1
1Other, 2Beatson Institute for Cancer Research

Understanding the role of chemo-radiotherapy in locally advanced, inoperable pancreatic adenocarcinoma as consolidation treatment after successful chemotherapy – which patients benefit?

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Arvind Arora1, Callum Eley2, Ankit Rao1
1Nottingham City Hospital, 2University of Nottingham

Early colorectal cancer treatment and outcomes in Scotland: real world evidence from national linked administrative data

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Elizabeth Lemmon1, Elizabeth Lemmon1, Peter Hall1, Catherine Hanna2, Katharina Diernberger1, Eva Morris3
1University of Edinburgh, 2University of Glasgow, 3University of Oxford

Imaging modality and frequency in surveillance of stage I seminoma testicular cancer: Results from a randomised, phase III, non-inferiority trial (TRISST)

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Johnathan Joffe1, Fay Cafferty2, Laura Murphy2, Gordon Rustin3, Aslam Sohaib4, Rhian Gabe5, Sally Stenning2, Elizabeth James2, Dipa Noor2, Simona Wade2, Francesca Schiavone2, Sarah Swift6, Elaine Dunwoodie6, Marcia Hall3, Anand Sharma3, Jeremy Braybrooke7, Jonathan Shamash8, John Logue9, Henry Taylor2, Ivo Hennig10, Jeff White11, Sarah Rudman12, Jane Worlding13, Richard Kaplan2, Robert Huddart4
1Calderdale and Huddersfield NHS Foundation Trust, 2Other, 3Mount Vernon Cancer Centre, 4Institute of Cancer Research (ICR), 5Queen Mary University of London, 6St James’s Hospital, 7University Hospitals Bristol NHS Foundation Trust, 8Barts Cancer Institute, 9The Christie NHS Foundation Trust, 10Nottingham University Hospitals NHS Trust, 11Beatson West of Scotland Cancer Centre, 12Guy’s and St Thomas’ NHS Foundation Trust, 13University Hospitals Coventry and Warwickshire NHS Trust

Serum bilirubin and risk of overall and site-specific cancer in the Swedish AMORIS cohort: a prospective study and meta-analysis

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Maria Jose Monroy-Iglesias1, Charlotte Moss1, Niklas Hammar2, Goran Walldius2, Lars Holmberg2, Mieke Van Hemelrijck1, Cecilia Bosco1, Aida Santa Olalla1
1King’s College London (KCL), 2Karolinska Institutet

Barriers and facilitators to access and utilisation of post-treatment psychosocial support by Black prostate cancer survivors – a systematic review

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Olufikayo Bamidele1, Obrey Alexis2, Motolani Ogunsanya3, Sarah Greenley1, Aaron Worsley2, Elizabeth Mitchell1
1University of Hull, 2Oxford Brookes University, 3Other